A5004572581- Phagocytosis and Immune Regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Extracellular vesicles in disease
- COVID-19 Clinical Research Studies
- Immune cells in cancer
- Platelet Disorders and Treatments
- Acute Myeloid Leukemia Research
- Glutathione Transferases and Polymorphisms
- Rheumatoid Arthritis Research and Therapies
- Neurological Disorders and Treatments
- Retinoids in leukemia and cellular processes
- Estrogen and related hormone effects
- Blood disorders and treatments
- Selenium in Biological Systems
- Blood Coagulation and Thrombosis Mechanisms
- Systemic Lupus Erythematosus Research
- Acute Ischemic Stroke Management
- Mathematical and Theoretical Analysis
- Zebrafish Biomedical Research Applications
- Inflammatory Biomarkers in Disease Prognosis
- Advanced Mathematical Physics Problems
- Inflammatory mediators and NSAID effects
- Eosinophilic Disorders and Syndromes
- MicroRNA in disease regulation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Dalian University of Technology
2024
Xi'an International Studies University
2022
Harbin Medical University
2017-2021
First Affiliated Hospital of Harbin Medical University
2017-2021
National Health and Family Planning Commission
2018-2019
Xi'an Jiaotong University
2018-2019
Chuxiong Normal University
2009
Sun Yat-sen University
2005
Despite the presence of neutrophil extracellular traps [NETs] in inflamed colon having been confirmed, role NETs, especially circulating progression and thrombotic tendency inflammatory bowel disease [IBD] remains elusive. We extended our previous study to prove that NETs constitute a central component prothrombotic state IBD.In all 48 consecutive patients with IBD were studied. Acute colitis was induced by treatment C57BL/6 mice 3.5% dextran sulphate sodium [DSS] drinking water for 6 days....
BackgroundThe role of neutrophil extracellular traps (NETs) in procoagulant activity (PCA) stroke patients caused by thromboembolic occlusion the internal carotid artery (ICA) remains unclear. Our objectives were to evaluate critical NETs induction hypercoagulability and identify functional significance during atherothrombosis.MethodsThe levels NETs, activated platelets (PLTs), PLT-derived microparticles (PMPs) detected plasma 55 35 healthy controls. NET formation thrombi analysed using...
The present study aimed to identify potential novel biomarkers in synovial tissue obtained from patients with Rheumatoid Arthritis (RA) and Osteoarthritis (OA) for differential diagnosis. genome‑wide expression profiling datasets of tissues RA OA cohorts, including GSE55235, GSE55457 GSE55584 datasets, were retrieved used differentially expressed genes (DEGs; P<0.05; false discovery rate <0.05 Fold Change >2) between using R software. Gene Ontology Kyoto Encyclopedia Genes Genomes pathway...
Neoadjuvant chemotherapy is relevant to the formation of thromboembolism and secondary neoplasms in triple-negative breast cancer (TNBC). Chemotherapy-induced cell-derived microparticles (BCMPs) may have important thrombogenic pro-metastatic effects on platelets endothelium, which be related expression distribution phosphatidylserine (PS). However, investigating these interactions challenging due technical limitations.
Multiple myeloma (MM) is characterized by an increased incidence of thromboembolic events, particularly when treated with immunomodulatory drugs (IMiDs) in combination dexamethasone. The optimal prophylactic strategy to prevent the hypercoagulable state patients MM still debated. aim current study was investigate definitive role phosphatidylserine (PS) supporting procoagulant activity (PCA) MM. Patients (n=20) and healthy subjects (n=15) were recruited for present study. PS analyses...
Abstract Osteoarthritis (OA) is one of the most common forms arthritis world widely. Some key genes and diagnostic markers have been reported due to development modern molecular biology technologies. However, etiology pathogenesis OA remains unknown. In this study, an integrated network pathway analysis towards biological function OA‐associated was conducted provide valuable information further explore OA. A total 2,548 which a statistically significant association with were screened. An...
BackgroundThe role of vascular endothelium in acute promyelocytic leukaemia (APL) remains unknown. We aimed to investigate the mechanisms by which APL cells interact with endothelial (ECs) and further explore how affects bleeding as well therapeutic interventions.MethodAPL an original cell line, NB4 cells, were used for experiments. The effects leukaemic on ECs analyzed vitro vivo. Moreover, barrier function procoagulant activity detected. An mouse model was established vivo...
Phosphatidylserine (PS) is essential for inflammation-associated thrombogenesis, but the exact effect of PS on prothrombotic state in periodontitis uncertain. This study aimed to determine PS-related procoagulant patients with periodontitis.A total 138 were examined compared 42 healthy controls. PS-exposing cells and microvesicles blood samples detected by confocal microscopy flow cytometry. The clotting time assay prothrombinase complex formation used measure activity microvesicles,...
The fuzzy SOFM-GIS space cluster model is a new based on theory of fuzzy, self-organizing feature map network and GIS. Fuzzy used to solve uncertain problems. GIS strong analysis ability. Self-organizing are ability self-learned, self-adaptive, error-permissive identification. adapted problem multiple objects under multi-index condition in or systems these characteristic. It classify the red soil resource Zhejiang province. results show that stable reliable.
Background: The role of neutrophil extracellular traps (NETs) in procoagulant activity (PCA) stroke patients caused by thromboembolic occlusion the internal carotid artery (ICA) remains unclear. Our objectives were to evaluate critical NETs induction hypercoagulability and identify functional significance during atherothrombosis.Methods: levels NETs, activated platelets (PLTs), PLT-derived microparticles (PMPs) detected plasma 55 with ICA 35 healthy controls. NET formation thrombi analyzed...