A5034476106- Catalytic C–H Functionalization Methods
- Cyclopropane Reaction Mechanisms
- Asymmetric Hydrogenation and Catalysis
- Mitochondrial Function and Pathology
- Catalytic Alkyne Reactions
- Muscle Physiology and Disorders
- Neurogenetic and Muscular Disorders Research
- Neurological Disease Mechanisms and Treatments
- Synthesis and Catalytic Reactions
- Phagocytosis and Immune Regulation
- Asymmetric Synthesis and Catalysis
- Genetic Neurodegenerative Diseases
- Catalysis for Biomass Conversion
- Neurological Disorders and Treatments
- Fluorine in Organic Chemistry
- Sulfur-Based Synthesis Techniques
- ATP Synthase and ATPases Research
- Neuroblastoma Research and Treatments
- Inflammasome and immune disorders
- Autoimmune Neurological Disorders and Treatments
- RNA regulation and disease
- Platelet Disorders and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Radical Photochemical Reactions
- Receptor Mechanisms and Signaling
Nanfang Hospital
2009-2025
Southern Medical University
2009-2025
Ganzhou People's Hospital
2025
First Affiliated Hospital of Harbin Medical University
2018-2024
Harbin Medical University
2018-2024
Henan Normal University
2023
Dalian Institute of Chemical Physics
2021
Chinese Academy of Sciences
2021
Wuhan University
2016-2019
Harbin University
2018
The first enantioselective vinylogous aldol–cyclization cascade reaction of allyl pyrazoleamides with isatins is reported. With 1 mol% Takemoto catalyst, optically active spirocyclic oxindole–dihydropyranones were obtained in excellent yields (93–99%) and good-to-excellent enantioselectivities (82–97% ee).
The nickel/(S)-Binapine complex was found to be an efficient catalyst for asymmetric hydrogenation of β-acetylamino vinylsulfones afford chiral β-Amido sulfones with excellent yields and enantioselectivities (up 95% >99% ee). This protocol has good compatibility a series substituted (Z)-β-acetylamino or Z/E isomeric mixtures. A gram-scale reaction also been achieved in the presence 0.2 mol % loading.
Nickel-catalyzed stereospecific <italic>syn</italic>-selective asymmetric hydrogenation of challenging tetrasubstituted fluorinated enamides has been achieved. This protocol provides an efficient access to chiral α-fluoro-β-amino esters.
Limb-girdle muscular dystrophy R8 (LGMD R8) is a hereditary muscle disease caused by biallelic defects in E3 ubiquitinated ligase gene (TRIM32). LGMD featured high genetic heterogeneity and phenotypic diversity, most pathogenic variants are missense located the NHL domain, but genotype-phenotype correlation remains unclear. We hypothesized that various domain might have different degrees of impact on structure function protein, thus resulting variability. Firstly, analyzing present patients'...
Abstract The Mizoroki-Heck reaction and its reductive analogue are staples of organic synthesis, but the ensuing products often lack a chemical handle for further transformation. Here we report an atom-economical cross-coupling halopyridines unactivated alkenes under photoredox catalysis to afford series alkene halopyridylation products. This protocol with mild redox neutral conditions contributes broad substrate scope. As complement conventional Heck-type reaction, this radical process...
Abstract An enantioselective rhodium(I)‐catalyzed cycloisomerization reaction of challenging (E)‐1,6‐enynes is reported. This novel process enables with a wide range functionalities, including nitrogen‐, oxygen‐, and carbon‐tethered (E)‐1,6‐enynes, to undergo excellent enantioselectivity, in high‐yielding operationally simple manner. Moreover, this Rh I ‐diphosphane catalytic system also exhibited superior reactivity enantioselectivity for (Z)‐1,6‐enynes. A rationale the striking difference...
Limb-girdle muscular dystrophy R8 (LGMD R8) is a rare autosomal recessive muscle disease caused by TRIM32 gene biallelic defects. The genotype-phenotype correlation of this has been reported poorly. Here, we report Chinese family with two female LGMD patients.We performed whole-genome sequencing (WGS) and Sanger on the proband. Meanwhile, function mutant protein was analyzed bioinformatics experimental analysis. In addition, summary deletions point mutations an investigation were through...
An iridium-catalyzed highly efficient asymmetric hydrogenation of challenging tetrasubstituted α-fluoro-β-enamino esters was successfully developed using bisphosphine–thiourea (ZhaoPhos) as the ligand, which prepared a series chiral α-fluoro-β-amino containing two adjacent tertiary stereocenters with high yields and excellent diastereoselectivities/enantioselectivities (73%–99% yields, >25:1 dr, 91%−>99% ee, turnover number (TON) values up to 8600), no defluorinate byproduct detected.
Rhodium-catalyzed asymmetric hydrogenation of challenging tetrasubstituted β-acetoxy-α-enamido esters was developed, giving chiral β-acetoxy-α-amido in high yields with excellent enantioselectivities. This protocol provides an efficient route for the synthesis droxidopa.
Abstract Transition-metal-catalyzed cycloisomerization of 1,n-allenynes represents a powerful synthetic tool to rapidly assemble complex polycyclic skeletons from simple linear substrates. Nevertheless, there are no reports the asymmetric version these reactions. Moreover, most reactions proceed through 6-endo-dig cyclization pathway, which preferentially delivers distal product (via 5/5 rhodacyclic intermediate) rather than proximal one 6/5 intermediate). Herein, we report an...
A direct dearomative [4 + 2] annulation of electron-poor N-heteroarenes with azoalkenes generated in situ from α-halogeno hydrazones was developed under mild conditions. Accordingly, a series fused polycyclic tetrahydro-1,2,4-triazines potential biological activity were obtained up to 96% yield. Various and N-heteroarenes, such as pyridines, quinolines, isoquinolines, phenanthridine, benzothiazole, tolerated by this reaction. The general applicability method shown upscale synthesis product...
Deafness-dystonia-optic neuronopathy (DDON) syndrome is a progressive X-linked recessive disorder characterised by deafness, dystonia, ataxia and reduced visual acuity. The causative gene deafness/dystonia protein 1 (DDP1)/translocase of the inner membrane 8A (TIMM8A) encodes mitochondrial intermembrane space chaperon. molecular mechanism DDON remains unclear, detailed information on animal models has not been reported yet.We characterized family with syndrome, in which affected members...
Abstract An enantioselective rhodium(I)‐catalyzed cycloisomerization reaction of challenging (E)‐1,6‐enynes is reported. This novel process enables with a wide range functionalities, including nitrogen‐, oxygen‐, and carbon‐tethered (E)‐1,6‐enynes, to undergo excellent enantioselectivity, in high‐yielding operationally simple manner. Moreover, this Rh I ‐diphosphane catalytic system also exhibited superior reactivity enantioselectivity for (Z)‐1,6‐enynes. A rationale the striking difference...
With recent large-scale applications and validations, the relative binding free energy (RBFE) calculated using alchemical methods has been proven to be an accurate measure probe of small-molecule drug candidates. On other hand, given flexibility peptides, it is great interest find out whether sufficient sampling could achieved within typical time scale such calculation, a similar level accuracy reached for peptide drugs. However, systematic evaluation calculations on protein–peptide systems...
An efficient and modular synthetic route to the bidentate C3*-TunePhos was developed, which allowed tunable steric electronic effects of ligands. This novel chemical technology highlights a versatile C3*-dibromodiphenyl intermediate that accomplished by in situ Grignard exchange subsequent Cu(II)-mediated intramolecular oxidative radical coupling process. It is worth noting this advanced not only could be easily prepared diverse array C3*-TunePhos-type ligands, but also used facile...