A5049276811- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Phagocytosis and Immune Regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Platelet Disorders and Treatments
- SARS-CoV-2 and COVID-19 Research
- Extracellular vesicles in disease
- Retinoids in leukemia and cellular processes
- Thermal Regulation in Medicine
- Inflammasome and immune disorders
- Acute Myeloid Leukemia Research
- COVID-19 and healthcare impacts
- MicroRNA in disease regulation
- Respiratory Support and Mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Nitric Oxide and Endothelin Effects
- Vasculitis and related conditions
- Acute Ischemic Stroke Management
- Blood disorders and treatments
- Oral microbiology and periodontitis research
- Muscle and Compartmental Disorders
- Immune cells in cancer
- Zebrafish Biomedical Research Applications
First Affiliated Hospital of Harbin Medical University
2018-2023
Harbin Medical University
2018-2023
Neoadjuvant chemotherapy is relevant to the formation of thromboembolism and secondary neoplasms in triple-negative breast cancer (TNBC). Chemotherapy-induced cell-derived microparticles (BCMPs) may have important thrombogenic pro-metastatic effects on platelets endothelium, which be related expression distribution phosphatidylserine (PS). However, investigating these interactions challenging due technical limitations.
BackgroundThe role of vascular endothelium in acute promyelocytic leukaemia (APL) remains unknown. We aimed to investigate the mechanisms by which APL cells interact with endothelial (ECs) and further explore how affects bleeding as well therapeutic interventions.MethodAPL an original cell line, NB4 cells, were used for experiments. The effects leukaemic on ECs analyzed vitro vivo. Moreover, barrier function procoagulant activity detected. An mouse model was established vivo...
Phosphatidylserine (PS) is essential for inflammation-associated thrombogenesis, but the exact effect of PS on prothrombotic state in periodontitis uncertain. This study aimed to determine PS-related procoagulant patients with periodontitis.A total 138 were examined compared 42 healthy controls. PS-exposing cells and microvesicles blood samples detected by confocal microscopy flow cytometry. The clotting time assay prothrombinase complex formation used measure activity microvesicles,...