A5033619307- Nanoplatforms for cancer theranostics
- Glioma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Photodynamic Therapy Research Studies
- Immune cells in cancer
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Extracellular vesicles in disease
- Photoacoustic and Ultrasonic Imaging
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Single-cell and spatial transcriptomics
- S100 Proteins and Annexins
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- Angiogenesis and VEGF in Cancer
- Ion Transport and Channel Regulation
- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- interferon and immune responses
- Ultrasound and Hyperthermia Applications
Hangzhou Medical College
2021-2025
Zhejiang Provincial People's Hospital
2021-2025
Harbin Medical University
2015-2024
Second Affiliated Hospital of Harbin Medical University
2015-2024
First Affiliated Hospital of Bengbu Medical College
2024
Sichuan University
2023
West China Hospital of Sichuan University
2023
First Affiliated Hospital of Harbin Medical University
2016
<h3>Objective:</h3> Neutrophil extracellular traps (NETs) produced by tumor-infiltrating neutrophils (TINs) are associated with poor prognosis in patients several types of cancer. However, the mechanisms underlying involvement NETs glioma progression remain largely unknown. This study aimed to elucidate roles biological processes that drive crosstalk between and tumor microenvironment. <h3>Methods:</h3> infiltration formation were investigated tissue through immunohistochemistry, their...
BackgroundThe role of neutrophil extracellular traps (NETs) in procoagulant activity (PCA) stroke patients caused by thromboembolic occlusion the internal carotid artery (ICA) remains unclear. Our objectives were to evaluate critical NETs induction hypercoagulability and identify functional significance during atherothrombosis.MethodsThe levels NETs, activated platelets (PLTs), PLT-derived microparticles (PMPs) detected plasma 55 35 healthy controls. NET formation thrombi analysed using...
m6A RNA methylation is an emerging epigenetic modification, and its potential role in immunity stemness remains unknown. Based on 17 widely recognized regulators, the modification patterns corresponding characteristics of immune infiltration 1152 low-grade glioma samples were comprehensively analyzed. Machine-learning strategies for constructing m6AScores trained to quantify individual samples. Here, we reveal a significant correlation between multi-omics data regulators clinicopathological...
Coagulopathy contributes to the majority of deaths and disabilities associated with traumatic brain injury (TBI). Whether neutrophil extracellular traps (NETs) contribute an abnormal coagulation state in acute phase TBI remains unknown. Our objectives were demonstrate definitive role NETs coagulopathy TBI. We detected NET markers 128 patients 34 healthy individuals. Neutrophil-platelet aggregates blood samples from individuals using flow cytometry staining for CD41 CD66b. Endothelial cells...
Abstract Aims Neutrophil extracellular traps (NETs) have been implicated in thrombotic diseases. There is no definitive explanation for how NETs form during acute ischemic strokes (AIS). The purpose of our study was to investigate the potential mechanism and role formation AIS process. Methods As well as 45 healthy subjects, patients with had ELISA tests performed detect NET markers. Expression high-mobility group box 1 (HMGB1) on platelet microvesicles (PMVs) analyzed by flow cytometry...
Sodium–hydrogen exchanger isoform 1 (NHE1) plays a role in survival and migration/invasion of several cancers is an emerging new therapeutic target. However, the NHE1 glioblastoma interaction expression function cells with cytotoxic temozolomide (TMZ) therapy remain unknown. In this study, we detected high levels protein only primary human glioma (GC), xenografts glioblastoma, but not neural stem or astrocytes. GC exhibited alkaline resting pHi (7.46±0.04) maintained by robust NHE1-mediated...
Abstract Ferroptosis and cuproptosis are emerging modes of programmed cell death have been increasingly used to eliminate tumor cells. However, converting ferroptosis/cuproptosis into effective treatments is challenging because the inherent antioxidant plasma membrane repair systems inefficient copper ion delivery. Herein, an engineered doping method developed encapsulate ZnO 2 with Cu 2+ ‐doped ZIF‐8 modify surface by transferrin (Tf). In resulting @Cu/ZIF‐8‐Tf nanosystem, Tf specifically...
N6-methyladenosine (m6A) RNA methylation, the most common form of mRNA modification and regulated by m6A methylation regulators ("writers," "erasers," "readers"), has been reported to be associated with progression malignant tumor. However, its role in glioblastoma (GBM) poorly known. This study aimed identify expression, potential functions, prognostic values GBM. Here, we revealed that 13 central were firmly related clinical molecular phenotype Taking advantage consensus cluster analysis,...
The progression of most human cancers mainly involves the gradual accumulation loss differentiated phenotypes and sequential acquisition progenitor stem cell-like features. Glioblastoma multiforme (GBM) cells (GSCs), characterized by self-renewal therapeutic resistance, play vital roles in GBM. However, a comprehensive understanding GBM stemness remains elusive. Two indices, mRNAsi EREG-mRNAsi, were employed to comprehensively analyze stemness. We observed that was significantly related...
Neutrophil extracellular traps (NETs) contribute to the creation of a coagulation state in various diseases. Currently, it is not clear whether NETs are present thrombi and plasma patients with cerebral venous sinus thrombosis (CVST). This study aimed investigate presence blood samples from CVST procoagulant activity (PCA) during progression CVST.Thrombi obtained undergoing thrombectomy were examined by immunochemistry using neutrophil elastase (NE), CD66b citrullinated histone H3(citH3)....
5-Methylcytosine (m5C) methylation is an important RNA modification pattern that can participate in oncogenesis and progression of cancers by affecting stability, expression oncogenes, the activity cancer signaling pathways. Alterations long non-coding RNAs (lncRNAs) are potentially correlated with abnormalities m5C regulation features cancers. Our aim was to reveal mechanisms which lncRNAs regulated process, explore impact aberrant on biological properties lower-grade gliomas (LGG),...
Background The murine model of cerebral aneurysm (CA) serves as a prevalent tool for investigating the molecular underpinnings CA. However, extent to which CA aligns with that human remains elusive. Methods present study employed comprehensive integration and exploration single-cell RNA-seq (scRNA-seq) datasets, along multiple trajectory gene regulatory network analyses, investigate cellular discrepancies between CAs. Results uniform manifold approximation projection (umap) embedding...
Sonodynamic therapy (SDT) has shown great potential as an approach for cancer treatment, and hyperthermotherapy (HT) is also a promising therapy. Here, we investigate whether HT could improve the efficacy of SDT to make preliminary exploration on mechanism. Xenograft tumor was established in nude mice model, SNB19 U87MG glioma cell lines were utilized vitro experiment. Alamar blue assay performed assess viability. Optical microscope used characterize morphology changes cells induced by...
Abstract Despite the high efficacy and safety of arsenic trioxide (ATO) in treating acute promyelocytic leukemia (APL) eradicating APL leukemia-initiating cells (LICs), mechanism underlying its selective cytotoxicity remains elusive. We have recently demonstrated that undergo a novel cell death program, termed ETosis, through autophagy. However, role ETosis ATO-induced LIC eradication unclear. For this study, we evaluated effects ATO on contributions drug-induced to eradication. In NB4...
The WNK-SPAK kinase signaling pathway controls renal NaCl reabsorption and systemic blood pressure by regulating ion transporters channels. A WNK3-SPAK complex is highly expressed in brain, but its function this organ remains unclear. Here, we investigated the role of brain edema white matter injury after ischemic stroke. Wild-type, WNK3 knockout, SPAK heterozygous or knockout mice underwent transient middle cerebral artery occlusion. One cohort magnetic resonance imaging. Ex-vivo brains...
The aim of the present study was to examine apoptosis-promoting effects and mechanisms hematoporphyrin monomethyl ether (HMME)-sonodynamic therapy (SDT) on endometrial cancer cells in vitro.Endometrial cell samples were divided into four groups: 1) untreated control group, 2) HMME 3) pure ultrasound 4) combined with ultrasound, i.e. SDT group. CCK-8 method utilized assess inhibiting effect proliferation cells. Optical microscope field emission transmission electron microscopy used...
Temozolomide (TMZ) was used for clinical postoperative or non-surgical chemotherapy patients. However, its effect remains unsatisfactory and gradually discovered that the presence of chemoresistance. To explore more effective therapy using TMZ, we investigate effects combination application TMZ together with Sonodynamic (SDT), which is based on ultrasonic activation a sonosensitizer, low toxicity, noninvasive, deeper penetrability promising approach treating malignant glioma by inducing...
Background Although mRNA vaccines have been efficient for combating a variety of tumors, their effectiveness against glioma remains unclear. There is growing evidence that immunophenotyping can reflect the comprehensive immune status and microenvironment tumor, which correlates closely with treatment response vaccination potency. The purpose this research was to screen effective antigens in could be used developing further differentiate subtypes create an selection criteria suitable patients...