Abstract Persistent luminescence (PL) is a distinctive optical phenomenon with long‐lasting afterglow emissions after the cessation of excitation, thus emerging huge prospects in applications anti‐counterfeiting, information or data storage, photocatalysis, sensing, and bioimaging. In this regard, it great importance to optimize PL performance. Recently, no comprehensive literature review on inorganic persistent phosphors reported aid researchers focusing systematic adjustment properties...

Abstract Taking the significance of special microenvironment for tumor cell survival into account, disrupting redox homeostasis is highly prospective improving therapeutic efficacy. Herein, a multifunctional 2D vanadium‐based MXene nanoplatform, V 4 C 3 /atovaquone@bovine albumin (V /ATO@BSA, abbreviated as VAB) has been elaborately constructed ATO‐enhanced nanozyme catalytic/photothermal therapy. The within cells eventually disrupted, showing remarkable anti‐tumor effect. VAB nanoplatform...

Abstract Hydrogen sulfide (H 2 S) is being progressively integrated as an emerging inhibitor of the electron transport chain in energy interference‐based tumor therapy. However, metabolic reprogramming cancer cells causes both oxidative phosphorylation (OXPHOS) and glycolysis to occur simultaneously, which contributes ineffective therapeutic effect blocking a single pathway. To achieve complete suppression production, inorganic H S donor ZnS@ZIF‐8@CaP nanoparticle (ZSZC NP) carrying Ca Zn...

Abstract Cuproptosis and ferroptosis hold great promise for overcoming apoptotic resistance in liver cancer based on their unique metal‐driven cell death modalities. However, insufficient intracellular copper iron concentration, complicated tumor microenvironment (TME), unclear cross‐regulatory mechanisms between cuproptosis ferroptosis, severely restrict the therapeutic performance. Herein, copper‐doped hollow Prussian blue (CHP) nanozymes are rationally designed loading photosensitizer...

With the rapid development of external minimally invasive or noninvasive therapeutic modalities, ultrasound-based sonodynamic therapy (SDT) is a new alternative for treating deep tumors. However, inadequate sonosensitizer efficiency and poor biosecurity limit clinical applications. In this study, we prepared an oxygen-vacancy-engineered W

Mild photothermal therapy (PTT, <45 °C) can prevent tumor metastasis and heat damage to normal tissue, compared with traditional PTT (>50 °C). However, its therapeutic efficacy is limited owing the hypoxic environment thermoresistance overproduction of shock proteins (HSPs). Herein, a near-infrared (NIR)-triggered theranostic nanoplatform (GA-PB@MONs@LA) designed for synergistic mild enhanced Fenton nanocatalytic against tumors. The fabricated by confined formation Prussian blue (PB)...

The emergence of X-ray-induced photodynamic therapy (X-PDT) holds tremendous promise for clinical deep-penetrating cancer therapy. However, the application X-PDT in treatment is still limited due to hypoxic property cancerous tissue, inherent antioxidant system tumor cells, and difficulty matching absorption spectra photosensitizers. Herein, a versatile core–shell radiosensitizer (SCNPs@DMSN@CeOx-PEG, denoted as SSCP) was elaborately designed constructed enhance by coating tunable mesoporous...

Nanosystem-mediated tumor radiosensitization strategy combining the features of X-ray with infinite penetration depth and high atomic number elements shows considerable application potential in clinical cancer therapy. However, it is difficult to achieve satisfactory anticancer efficacy using radiotherapy for majority solid tumors due restrictions brought about by hypoxia, insufficient DNA damage, rapid repair during after treatment. Inspired complementary advantages nitric oxide (NO)...

The development of a manageable reactive nitrogen species-potentiated nitrosative stress induction system for cancer therapy has remained elusive. Herein, tailored silica-based nanoscintillators were reported low-dosage X-ray boosting the in situ formation highly cytotoxic peroxynitrite (ONOO–). Significantly, cellular revolving around intracellular protein tyrosine nitration through ONOO– pathways was explored. High-energy X-rays directly deposited on nanoscintillators, forming concept an...

Abstract In reactive‐oxygen‐species‐mediated tumor therapy, the generation and accumulation of ·OH is highly dependent on peroxidase (POD)‐like enzymatic activities antioxidant microenvironment. As noble metal nanoalloys can enhance POD‐like activity by improving electron transfer upgrading active sites, PdCu x ( = 0.6–1.2) bimetallic with optimized activity, enhanced photothermal conversion efficiency, altered glutathione (GSH) consumption ability are synthesized a facile co‐reduction...

In article number 2202382, Shili Gai, Piaoping Yang, and co-workers review the inorganic persistent phosphors that are of interest for dopant host selection criteria, afterglow intensity multi-color modulating methods, from perspectives composition optimization, defect dynamics coordination environment hosts. Persistent luminescence imaging multimodal introduced. This will be a guideline design, synthesis optical performance optimization materials in future.

Abstract Nanoformulations with endogenous/exogenous stimulus‐responsive characteristics show great potential in tumor cell elimination minimal adverse effects and high precision. Herein, an intelligent nanotheranostic platform (denoted as TPZ@Cu‐SnS 2‐x /PLL) for microenvironment (TME) near‐infrared light (NIR) activated tumor‐specific therapy is constructed. Copper (Cu) doping the resulting sulfur vacancies can not only improve response range of visible but also separation efficiency...

Mitochondria are the "power plant" of cell, providing a constant source energy, and involved in variety intracellular signaling pathways. Among these pathways, Ca2+ homeostasis is closely related to normal function mitochondria. By destroying steady state mitochondria disrupting their multiple cellular activities, tumor cell killing can be achieved. In addition, presence an oxidative stress triggers closure calcium channels, which leads retention enrichment. We designed targeted...

Therapeutic nanosystems triggered by a specific tumor microenvironment (TME) offer excellent safety and selectivity in the treatment of cancer situ conversion less toxic substance into effective anticarcinogens. However, inherent antioxidant systems, hypoxic environment, insufficient hydrogen peroxide (H2O2) cells severely limit their efficacy. Herein, new strategy has been developed loading chemotherapy prodrug disulfiram (DSF) coating glucose oxidase (GOD) on surface Cu/ZIF-8 nanospheres...

Ferroptosis, as a non-apoptotic cell death pathway, has attracted increasing attention for cancer therapy. However, the clinical application of ferroptosis-participated modalities is severely limited by low efficiency owing to intrinsic intracellular regulation pathways. Herein, chlorin e6 (Ce6) and N-acetyl-l-cysteine-conjugated bovine serum albumin-ruthenium dioxide elaborately designed constructed ultrasound-triggered peroxynitrite-mediated ferroptosis. Upon ultrasound stimulation,...

Abstract Ferroptosis and cuproptosis are emerging modes of programmed cell death have been increasingly used to eliminate tumor cells. However, converting ferroptosis/cuproptosis into effective treatments is challenging because the inherent antioxidant plasma membrane repair systems inefficient copper ion delivery. Herein, an engineered doping method developed encapsulate ZnO 2 with Cu 2+ ‐doped ZIF‐8 modify surface by transferrin (Tf). In resulting @Cu/ZIF‐8‐Tf nanosystem, Tf specifically...

Nanozymes with the merits of effective enzyme-mimic activities, tunable catalytic properties, pH/temperature tolerance, and high stability have been consumingly researched for nanocatalytic therapy. Herein, union nanozymes a natural enzyme nanoplatform (DMSN@CoFe2O4/GOD-PCM) are elaborately designed by simply depositing an ultrasmall cobalt ferrite (CoFe2O4) bimetallic oxide nanozyme glucose oxidase (GOD) that loaded into aperture (∼12 nm) dendritic mesoporous silica (DMSN)...

Current applications of multifunctional nanozymes for reprogramming the redox homeostasis tumor microenvironment (TME) have been severely confronted with low catalytic activity and ambiguity active sites nanozymes, as well stress resistance from rigorous physical environment cells. Herein, Sm/Co-doped mesoporous silica 3PO-loaded (denoted mSC-3PO) are rationally constructed simultaneously inhibiting energy production by adenosine triphosphate (ATP) inhibitor 3PO TME multiactivities...