A5100758636- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Erythrocyte Function and Pathophysiology
- Ion channel regulation and function
- Anesthesia and Neurotoxicity Research
- Traditional Chinese Medicine Analysis
- DNA Repair Mechanisms
- Photodynamic Therapy Research Studies
- Cancer, Hypoxia, and Metabolism
- Hemoglobin structure and function
- Hippo pathway signaling and YAP/TAZ
- Hydrogen's biological and therapeutic effects
- Bone and Dental Protein Studies
- Ginger and Zingiberaceae research
- 3D Printing in Biomedical Research
- Axon Guidance and Neuronal Signaling
- Cancer Genomics and Diagnostics
- Protease and Inhibitor Mechanisms
- RNA Research and Splicing
Sun Yat-sen University
2021-2024
Fifth Affiliated Hospital of Sun Yat-sen University
2021-2024
Southern Medical University
2023-2024
Nanfang Hospital
2023-2024
Zhuhai People's Hospital
2021
Jinan University
2021
Harbin Medical University
2017-2020
Second Affiliated Hospital of Harbin Medical University
2017-2020
Heilongjiang Academy of Sciences
2020
Fudan University Shanghai Cancer Center
2020
miR-152 and lncRNA H19 have been frequently implicated in various cellular processes including cell proliferation, invasion, angiogenesis, apoptosis. However, the interaction between glioma has never reported. RT-qPCR was used to examine expression of human lines normal astrocytes (NHAs). The assessed by dual-luciferase reporter assay. MTT assay Transwell invasion were determine proliferation U251 U87 cells. A xenograft tumor experiment performed confirm role vivo. results showed that...
N6-methyladenosine (m6A) RNA methylation, the most common form of mRNA modification and regulated by m6A methylation regulators ("writers," "erasers," "readers"), has been reported to be associated with progression malignant tumor. However, its role in glioblastoma (GBM) poorly known. This study aimed identify expression, potential functions, prognostic values GBM. Here, we revealed that 13 central were firmly related clinical molecular phenotype Taking advantage consensus cluster analysis,...
The progression of most human cancers mainly involves the gradual accumulation loss differentiated phenotypes and sequential acquisition progenitor stem cell-like features. Glioblastoma multiforme (GBM) cells (GSCs), characterized by self-renewal therapeutic resistance, play vital roles in GBM. However, a comprehensive understanding GBM stemness remains elusive. Two indices, mRNAsi EREG-mRNAsi, were employed to comprehensively analyze stemness. We observed that was significantly related...
Background/Aims: Thyroid carcinoma (TC) is a highly lethal malignant cancer and its carcinogenesis remains undetermined. Dysregulation of microRNAs (miRNAs) well known to be involved in the development various cancers, including TC, whereas role miR-3666 pathogenesis TC has not been appreciated. Methods: We analyzed levels MET tissue relationship with patients' prognosis. then overexpressed by miRNA mimics transfection inhibited antisense cells. Cell survival growth were CCK-8 assay MTT...
Temozolomide (TMZ) was used for clinical postoperative or non-surgical chemotherapy patients. However, its effect remains unsatisfactory and gradually discovered that the presence of chemoresistance. To explore more effective therapy using TMZ, we investigate effects combination application TMZ together with Sonodynamic (SDT), which is based on ultrasonic activation a sonosensitizer, low toxicity, noninvasive, deeper penetrability promising approach treating malignant glioma by inducing...
To better understand the Ca2+ overload mechanism of SDT killing gliomas, we examined hypothesis that early application mechanosensitive channel Piezo1 antagonist (GsMTx4) could have a anti-tumor effect.The in vitro effect low-energy combined with GsMTx4 or agonist Yoda 1 on both ROS-induced distribution as well opening and dissociation polymerization lipid complex were assessed. The same groups also studied to determine their effects tumor-bearing BALB/c-nude C57BL/6 intracranial tumors,...
The successful application of photodynamic therapy in the treatment glioma (CNS WHO grade 4) depends large part to effect killing cells infiltrating area after tumor had been removed, when combined with radiotherapy, chemotherapy, and targeted drug therapy. purpose this study was investigate potential mechanism TMZ's involvement glioma's glycolytic metabolic pathway during low dose on cell viability gliomas investigated by CCK8. Alterations reactive oxygen species were detected flow...
Long non-coding RNA KCNQ1 opposite strand/antisense transcript one gene (KCNQ1OT1) has been reported to be involved in the progression of many types human cancer, whereas its role gastric cancer (GC) remains unknown. The present study aimed investigate KCNQ1OT1 GC.
Abstract Aim Most of the subarachnoid hemorrhage (SAH) patients experienced symptom severe headache caused by intracranial hypertension. Piezo1 is a mechanosensitive ion channel protein. This study aimed to investigate effect on neurons in response Methods The SAH rat model was performed modified endovascular perforation method. inhibitor GsMTx4 administered intraperitoneally after induction. To underlying mechanism, selective agonist Yoda1, shRNA, and MY‐875 were via intracerebroventricular...
Long noncoding RNAs have key roles in glioma progression. However, the function and mechanisms of action long RNA, LINC00346, remain unclear. In our study, we observed that LINC00346 levels were increased tissue samples, according to Gene Expression Profiling Interactive Analysis, its related disease-free survival overall rates, suggesting a high level expression corresponds poor prognosis. We next confirmed tissues cell lines showed knockdown suppressed proliferation, migration invasion;...
<title>Abstract</title> Background As the strong adaptive radio-chemoresistance, GBM represents worst prognosis form of primary malignant tumor within central nervous system. Previous researches indistinctly focused on mechanisms resistance to X-ray or chemo regimen in isolation, however, it is still unknown if there exists synergistic interact effect between above two kinds resistances. Methods We established TMZ-resistant cell lines (TMZ-R) by chronically exposing U87MG TMZ, and DMSO was...
The aim of the present study was to assess expression status matrix metalloproteinase (MMP)-28 and investigate its molecular mechanisms in glioma cells. MicroRNA (miRNA) reverse transcription-quantitative polymerase chain reaction used analyze MMP-28 transforming growth factor (TGF)-β patients healthy volunteers. MTT Transwell assays were conducted determine cell metastasis, respectively. Annexin V/propidium iodide staining also employed measure apoptosis. TGF-β protein measured using...
Background Long non-coding RNA SPRY4 intronic transcript 1 (Lnc SPRY4-IT1) was aberrant-expressed in various kinds of cancer. Increasing evidence demonstrated that lnc RNAs involved tumorigenesis and metastasis. In this study, we aimed to explore the biological role SPRY4-IT1 on phenotype nasopharyngeal carcinoma (NPC) vitro vivo. Methods The expression level NPC cell lines were measured by quantitative real-time polymerase chain reaction (qRT-PCR). Cell Counting Kit-8 (CCK-8) colony...
Abstract Background: The radical cure of Glioblastoma multiforme (GBM) is a troublesome medical problem, owing to its resistance temozolomide chemotherapy and very poor surgical results or high relapse rate. Resistance emerges from numerous signalling pathways that are altered in GBM, especially the hedgehog pathway. Hence, further research urgent needed identify more effective treatment modalities. Methods: We evaluated effect ATO on viability, cell proliferation, colony formation...