A5083209300- Cardiac electrophysiology and arrhythmias
- 3D Printing in Biomedical Research
- interferon and immune responses
- Photoacoustic and Ultrasonic Imaging
- Nanoplatforms for cancer theranostics
- Vascular Tumors and Angiosarcomas
- Vascular Malformations and Hemangiomas
- Cancer Cells and Metastasis
- Chemotherapy-induced cardiotoxicity and mitigation
- Immunotherapy and Immune Responses
- Proteoglycans and glycosaminoglycans research
- Malaria Research and Control
- Nuclear Structure and Function
- Extracellular vesicles in disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Voice and Speech Disorders
- Skin and Cellular Biology Research
- Airway Management and Intubation Techniques
- PARP inhibition in cancer therapy
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Liver physiology and pathology
- Ion channel regulation and function
- Circular RNAs in diseases
- Pluripotent Stem Cells Research
National Center for Toxicological Research
2016-2024
United States Food and Drug Administration
2016-2024
Universitätsklinikum Gießen und Marburg
2010-2022
Philipps University of Marburg
2022
University Hospital Heidelberg
2020
University Medical Centre Mannheim
2020
Heidelberg University
2020
University of Arkansas for Medical Sciences
2015-2017
Shanghai Tenth People's Hospital
2011-2016
Tongji University
2011-2016
Abstract In vivo photoacoustic (PA) flow cytometry (PAFC) has already demonstrated a great potential for the diagnosis of deadly diseases through ultrasensitive detection rare disease‐associated circulating markers in whole blood volume. Here, we demonstrate first application this powerful technique early malaria label‐free parasite‐produced hemozoin infected red cells (iRBCs) as high‐contrast PA agent. The existing tests using smears can detect disease at 0.001–0.1% parasitemia. On...
Numerous drugs have the potential to prolong QT interval and may cause accidental cardiac arrest (torsades de pointes [TdP]). Women are at a higher risk than men for experiencing drug-induced TdP. Due lack of appropriate tools, few studies investigated whether genetic differences between women any effects on proarrhythmia. Sex hormones believed play predominant role in induction Recently, progress induced pluripotent stem cell (iPSC) technologies has made it possible utilize human...
Background/Aims: Thyroid carcinoma (TC) is a highly lethal malignant cancer and its carcinogenesis remains undetermined. Dysregulation of microRNAs (miRNAs) well known to be involved in the development various cancers, including TC, whereas role miR-3666 pathogenesis TC has not been appreciated. Methods: We analyzed levels MET tissue relationship with patients' prognosis. then overexpressed by miRNA mimics transfection inhibited antisense cells. Cell survival growth were CCK-8 assay MTT...
The goal of this research was to study the long-term impact medical interventions on circulating tumor cell (CTC) dynamics. We have explored whether compression, punch biopsy or resection cause dissemination CTCs into peripheral blood circulation using in vivo fluorescent flow cytometry and breast cancer-bearing mouse model inoculated with MDA-MB-231-Luc2-GFP cells mammary gland. Two weeks after inoculation, three groups mice were subject following interventions: (1) compression for 15...
Control of sickle cell disease (SCD) stage and treatment efficiency are still time-consuming which makes well-timed prevention SCD crisis difficult. We show here that in vivo photoacoustic (PA) flow cytometry (PAFC) has a potential for real-time monitoring circulating sickled cells mouse model. In data were verified by vitro PAFC photothermal (PT) PA spectral imaging red blood (sRBCs) expressing SCD-associated hemoglobin (HbS) compared to normal (nRBCs). discovered PT signal amplitudes from...
Conventional flow cytometry is a versatile tool for drug research and cell characterization. However, it poorly suited quantification of non-fluorescent proteins artificial nanomaterials without the use additional labeling. The rapid growth biomedical applications small nanoparticles (NPs) delivery contrast therapy enhancement, as well focused on natural pigments chromophores, demands high-throughput methods components. In this work, we present novel photoacoustic (PA) fluorescence (PAFFC)...
Abstract Many oncology drugs have been found to induce cardiotoxicity in a subset of patients, which significantly limits their clinical use and impedes the benefit lifesaving anticancer treatments. Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) carry donor-specific genetic information proposed for exploring interindividual difference drug-induced cardiotoxicity. Herein, we evaluated inter- intraindividual variability iPSC-CM-related assays presented proof concept...
Graphene-based nanomaterials (GBNs) are quickly revolutionizing modern electronics, energy generation and storage, clothing biomedical devices. Due to GBN's variety of physical chemical parameters that define their toxicity aggregation in suspension, interpreting its toxicology without accurate information on graphene's distribution behavior live organisms is challenging. In this work, we present a laser-based optical detection methodology for noninvasive pharmacokinetics analysis GBNs...
Objective: Anatomical study of surgical approaches endoscopic minimally invasive thyroidectomy (eMIT) and transoral partial parathyroidectomy (TOPP) was conducted to evaluate their safety feasibility. Material methods: After performing an eMIT- TOPP-procedure on fresh frozen human cadavers, a layer-by-layer dissection the floor mouth anterior cervical region carried out in five specimens. The blood vessels, nerves muscles related approach were exposed. Results: neck can be reached through...
More than twenty years after its discovery, the role of importin beta superfamily member Ran GTP-binding protein (RanBP) 17 is still ill defined. Previously, we observed notable RanBP17 RNA expression levels in head and neck squamous cell carcinoma (HNSCC) lines with disruptive TP53 mutations.We deployed HNSCC as well from other tumor entities such HCT116, MDA-MB-231 H460, which were derived colon, breast lung cancers respectively. RNAi was used to evaluate effect on proliferation. FACS...
Objective To observe the feasibility of 125I intra-operative implantation plus palliative resection gastric carcinoma for treatment advanced cancer infiltrating pancreas. Methods 125 I was implanted intraoperatively into residual pancreatic tissues after palliatively removed. Results From Feb. 2005 to Jun. 2009, 15 cases (9 male, 6 female) patients were treated with implantation. The patients' ages ranged from 41 78 years, median age 64 years old. There 10 neck or body pancreas and 5 head....