A5101578148- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Cavitation Phenomena
- Cancer, Hypoxia, and Metabolism
- Breast Cancer Treatment Studies
- Lymphatic System and Diseases
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Ginseng Biological Effects and Applications
- Lung Cancer Treatments and Mutations
- PI3K/AKT/mTOR signaling in cancer
- Ubiquitin and proteasome pathways
- MRI in cancer diagnosis
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- RNA and protein synthesis mechanisms
- Immune cells in cancer
- Ultrasound Imaging and Elastography
- Fibroblast Growth Factor Research
- Angiogenesis and VEGF in Cancer
- Chromosomal and Genetic Variations
- Ferroptosis and cancer prognosis
- Natural product bioactivities and synthesis
Gansu University of Traditional Chinese Medicine
2025
Harbin Medical University
2009-2024
Third Affiliated Hospital of Harbin Medical University
2011-2024
Abstract Tamoxifen (TAM) resistance poses a significant clinical challenge in human breast cancer and exhibits high heterogeneity among different patients. Rg3, an original ginsenoside known to inhibit tumor growth, has shown potential for enhancing TAM sensitivity cells. However, the specific role underlying mechanisms of Rg3 this context remain unclear. Aerobic glycolysis, metabolic process, been implicated chemotherapeutic resistance. In study, we demonstrate that elevated glycolysis...
The present study investigated enhancement of apoptosis induction and the mechanisms underlying calcium overload on C6 glioma cells in vitro, stimulated by low-level ultrasound combination with hematoporphyrin monomethyl ether (HMME). optimum frequency was determined 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. apoptotic rate, reactive oxygen species concentration decreased mitochondrial membrane potential (MMP) were analyzed flow cytometry. Morphological changes...
Paclitaxel (PTX) is a widely used chemotherapeutic drug effective against numerous cancers. To elucidate cellular pathways targeted by PTX and identify novel mechanisms of resistance, we SILAC based quantitative proteomic approach to evaluate global changes protein abundance in HeLa cells. We identified 347 proteins involved number biological processes including spindle assembly, mitotic exit, extracellular adhesion whose upon treatment. Notably, the tumor suppressor PDCD4 translation...
Background Lung cancer is emerging rapidly as the leading death cause in Chinese patients. The causal factors for lung development remain largely unclear. Here we employed an shRNA library-based loss-of-function screen a genome-wide and unbiased manner to interrogate potential tumor suppressor candidates immortalized human epithelial cell line BEAS-2B. Methods/Results Soft agar assays were conducted screening BEAS-2B cells infected with retroviral library acquired feature of...
Background: The triple-negative breast cancer (TNBC) is an aggressive characterized by the absence of estrogen receptor (ER), progesterone (PR) and human epidermal growth factor 2 (HER2). Preoperative mammography ultrasound features TNBC may potentially suggest characteristics disease assist in treatment decisions. Materials Methods: study covered 153 patients with from May 2011 to 2012 who were confirmed postoperative pathology results our hospital. We compared radiological findings among...
Abstract Background Accurate evaluation of axillary lymph node metastasis (LNM) in breast cancer is very important. A large number hyperplastic and dilated lymphangiogenesis cases can usually be found the pericancerous tissue to promote occurrence tumor metastasis.Shear wave elastography (SWE) used as an important means for evaluating stiffness. We determined stiffness by SWE diagnose LNM invasive (IBC). Methods Patients with clinical T1-T2 stage IBC who received surgical treatment our...
Ovarian cancer (OC) is a type of with high prevalence and shocking mortality in women around the world. Radioresistance major reason for OC relapse. Mounting studies have shown significant function dysregulated microRNAs (miRNAs) progression cellular response to irradiation. The present study inquired about mechanism microRNA (miR)-4478 regulating radiosensitivity cells. Results showed that miR-4478 was downregulated OC, low level indicated disappointing prognosis patients. Besides, cells...
A number of studies have demonstrated that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) may be used to evaluate microvessel density (MVD), and quantitatively reflect tumor angiogenesis. To investigate the dynamics, including angiogenesis cellularity, rabbit VX2 tumors during 4 weeks following implantation, present study DCE-MRI combined with diffusion-weighted (DWI) scan at 3 days, then 1, 2, 4-week intervals, implantation. The volume transfer coefficient (Ktrans) apparent...
Objective To study apoptotic effect and mechanisms of sonodynamic therapy (SDT) with hematoporphyrin monomethyl ether (HMME) on C6 glioma cells in vitro. Methods Time ultrasound irradiation was optimized by methyl thiazol tetrazolium (MTT) . Apoptotic rate( AR) generation reactive oxygen species (ROS) ,mitochondrial membrane potential (MMP) were detected flow cytometry ,and expressions apoptosis proteins measured Western blotting after SDT treatment. Results 60 s is the optimal time MTT when...