A5101438208- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Chemokine receptors and signaling
- RNA modifications and cancer
- Thyroid Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Ovarian cancer diagnosis and treatment
- Ultrasound and Hyperthermia Applications
- Prostate Cancer Treatment and Research
- Endometrial and Cervical Cancer Treatments
- RNA Research and Splicing
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- Otolaryngology and Infectious Diseases
- Photoacoustic and Ultrasonic Imaging
- interferon and immune responses
- Infectious Diseases and Tuberculosis
- Cancer Genomics and Diagnostics
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Intraperitoneal and Appendiceal Malignancies
- Cervical Cancer and HPV Research
Harbin Medical University
2009-2022
Third Affiliated Hospital of Harbin Medical University
2012-2022
Putian University
2012
Abstract Glutathione peroxidase 4 (GPX4) has been confirmed to inhibit ferroptosis in cancer cells, however, whether GPX4 serves as an oncogene is not clear. In this study, the expression of and its influence survival patients with were analyzed via public databases. Furthermore, epigenetic regulation relation between chemoresistance different anticancer drugs was also detected. Most importantly, cytological assays performed investigate function cells. The results showed that higher...
Sox2 is a major transcription factor and the transforming growth factor-α (TGF-α)/EGFR autocrine loop hallmark of prostate cancer progression. In this study, we have evaluated effects potential mechanisms on cell proliferation apoptosis, investigated TGF-α expression androgen-independent human cells.Expression has been determined by RT-PCR, western blot analysis immunocytochemistry, using RNAi over-expression strategy to study functions in DU145 PC-3 cells. Changes level proliferation, cycle...
Prostate cancer is the most commonly diagnosed type of and second leading cause cancer‑associated mortality in males. The efficacy prostate chemotherapy frequently impaired by drug resistance; however, underlying mechanisms this resistance remain elusive. Sex determining region Y-box 2 (Sox2) vital importance regulation stem cell proliferation carcinogenesis. In present study, using MTT, clone formation, cycle apoptosis assays, over-expression Sox2 was demonstrated to enhance paclitaxel...
Abstract Background As an oncogene, long noncoding RNA metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) can promote tumor metastasis. Hyperexpression of MALAT1 has been observed in many malignant tumors, including hepatocellular carcinoma (HCC). However, the role and mechanism HCC remain unclear. Methods Thirty human paracancerous tissue specimens were collected, hepatoma cell lines Huh7 HepG2 cultured according to standard methods. Snail family zinc finger (Slug) expression...
The unique CX3C chemokine CX3CL1 and its cognate receptor CX3CR1 have been implicated in organ-specific metastasis of various types tumors. Hypoxia, a common phenomenon solid tumors, is associated with malignant cancer phenotype. Previous studies proved that hypoxia facilitates cell through upregulation specific receptors. We hypothesized could upregulate expression lead to an increased chemotactic response prostate cells. In the present study, we found was significantly androgen-independent...
Transforming growth factor-α (TGF-α) is upregulated in advanced stages of prostate cancer and strongly correlated with metastasis. However, the effect TGF-α on epithelial-mesenchymal transition (EMT) underlying mechanisms remain unclear. Recently, microRNAs have emerged as new regulators EMT. This study found that treatment DU145 cells suppressed expression epithelial marker E-cadherin increased mesenchymal Vimentin well changed cell morphology from cobblestone shape to spindle shape. The...
Objective To explore the value of optimal parameters shear wave elastography (SWE) to enhance identification benign and malignant thyroid nodules by C-TIRADS. Methods The two-dimensional ultrasonography images SWE 515 patients with a total 586 were retrospectively analyzed. divided into D ≤10 mm >10 groups according size graded With pathological results as gold standard, receiver operating characteristic (ROC) curves drawn, area under curve (AUC) was calculated compare diagnostic...
Hypoxia is a common phenomenon in prostate cancer, which leads to cell proliferation and tumor growth. Fractalkine (FKN) membrane‑bound chemokine, implicated the progression of human cancer skeletal metastasis. However, association between FKN hypoxia‑induced remains be elucidated. The present study demonstrated that hypoxia induced expression secretion DU145 line. Furthermore, inhibiting activity with anti‑FKN FKN‑specific antibody markedly inhibited proliferation. Under normoxic...
To investigate the diagnostic performance of ADNEX model in International Ovarian Tumor Analysis models for ovarian tumors and further explore its application value staging tumors.A total 224 patients who underwent ultrasound evaluation adnexal masses were treated surgically owing to from January 2018 June 2020 our hospital selected research on accuracy model. The clinical information ultrasonographic findings collected, pathological diagnosis was taken as gold standard. According model,...
// Dong Li 1, * , Hui Sun 3, Wen-jing 1 Hong-bo Bao 4 Shu-han Si Jia-lin Fan Ping Lin Rong-jun Cui 5 Yu-jia Pan Si-min Wen Xiu-lan Zheng 2, $ Xiao-guang Yu Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China 2 Ultrasonography, University Cancer Hospital, 3 Clinical Laboratory, The Second School Inner Mongolia for Nationalities, (Inner Forestry General Hospital), Hulunbuir, 022150, Neurosurgery, Mudanjiang Mudanjiang, 157000,...
We report the formulation of nanoassemblies (NAs) comprising C225 conjugates Au-PFH-NAs (C-Au-PFH-NAs) for low-intensity focused ultrasound diagnosis ablation thyroid cancer. C-Au-PFH-NAs showed excellent stability in water, phosphate-buffered saline (PBS), and 20% rat serum. Transmission electron microscopy (TEM) images also revealed effective construction as common spherical assemblies. The incubation C625 carcinoma with triggers apoptosis, confirmed by flow cytometry analysis. exhibited...
Ovarian cancer (OC) is a type of with high prevalence and shocking mortality in women around the world. Radioresistance major reason for OC relapse. Mounting studies have shown significant function dysregulated microRNAs (miRNAs) progression cellular response to irradiation. The present study inquired about mechanism microRNA (miR)-4478 regulating radiosensitivity cells. Results showed that miR-4478 was downregulated OC, low level indicated disappointing prognosis patients. Besides, cells...
Abstract Chemotherapeutic efficacy can be significantly developed nanotheranostics systems of drug delivery in tumor cells. In this work, we have demonstrated that the self-assembled by C225 conjugates Au-PFH-NPs (C-Au-PFH-NPs) for low intensity focused ultrasound diagnosis ablation thyroid cancer treatment. C-Au-PFH-NPs shown excellent stability water, PBS and 20% rat serum. Transmission electron microscopy (TEM) images also exposed effective construction with commonly spherical sized...