A5055000333- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Biological Evaluation
- Catalytic C–H Functionalization Methods
- Synthesis and Reactivity of Heterocycles
- Synthesis and Catalytic Reactions
- Radioactive element chemistry and processing
- Synthesis and Characterization of Pyrroles
- Cyclopropane Reaction Mechanisms
- Synthesis and biological activity
- Chemical Synthesis and Analysis
- Catalytic Cross-Coupling Reactions
- Click Chemistry and Applications
- Multicomponent Synthesis of Heterocycles
- Dialysis and Renal Disease Management
- Cancer therapeutics and mechanisms
- Alkaloids: synthesis and pharmacology
- Luminescence and Fluorescent Materials
- Asymmetric Hydrogenation and Catalysis
- Extraction and Separation Processes
- Chemical Synthesis and Reactions
- Synthesis and Biological Activity
- Synthesis of Organic Compounds
- Central Venous Catheters and Hemodialysis
- Sulfur-Based Synthesis Techniques
Zhejiang University
2014-2025
Shenyang Jianzhu University
2024-2025
Pharmaceutical Biotechnology (Czechia)
2025
Soochow University
2023-2024
University of California, San Diego
2024
Second Affiliated Hospital of Jilin University
2015-2022
Jinhua Academy of Agricultural Sciences
2022
Hangzhou Academy of Agricultural Sciences
2019-2020
Hangzhou Xixi hospital
2019
East China University of Technology
2015-2016
A new synthetic protocol for efficient and regiospecifc assembly of indolizines pyrido[1,2-a]indoles by coupling substituted methyl bromides alkynes with corresponding pyrrole-2-carboxaldehyde 1H-indole-2-carboxaldehyde has been developed. Additionally, a possible mechanism the reaction is proposed.
A domino synthesis of pyrrolo[1,2-α]pyrazine from 1H-2-pyrrolecarbaldehyde and readily synthesized vinyl azides was developed. This reaction proceeded under relatively mild conditions in the presence base. Additionally, a possible mechanism for entire sequence is proposed.
Sox2 is a major transcription factor and the transforming growth factor-α (TGF-α)/EGFR autocrine loop hallmark of prostate cancer progression. In this study, we have evaluated effects potential mechanisms on cell proliferation apoptosis, investigated TGF-α expression androgen-independent human cells.Expression has been determined by RT-PCR, western blot analysis immunocytochemistry, using RNAi over-expression strategy to study functions in DU145 PC-3 cells. Changes level proliferation, cycle...
To investigate the clinical and histopathological features of non-diabetic renal disease (NDRD) superimposed on diabetic nephropathy (DN) in northeastern Chinese patients with type 2 diabetes mellitus (T2D), compare changes those pure DN isolated NDRD.Single-center retrospective analysis based medical records 273 (172 men, mean age: 51.1 ± 12.4 years) T2D who underwent biopsy between February 2000 October 2015. All were diagnosed as cases DN, NDRD or DN.Out patients, 68 (24.9 %) had 175...
The Rh(III)-catalyzed regioselective C–H amidation of N-methoxy-1H-indole-1-carboxamides by 1,4,2-dioxazol-5-ones was studied. N-Methoxy amide, the directing group (DG) interest, undergoes four different transformations through DG-retained, -coupled, -eliminated, or -migrated processes under moderately varied reaction conditions. Solvents, additives, and temperature play important roles in these selective transformations; a trace addition water favors functional (FG)-assisted DG elimination;...
In recent years, there has been significant interest in the development of self-compacting concrete (SCC). This study views SCC as a two-phase composite material and introduces new aggregate spacing coefficient model based on concept Fullman’s mean free path stereological theory. The validity was verified. relationship between fine coarse coefficients properties are revealed. results show that slump flow increase increase. influence compressive strength drying shrinkage SCC. A linear dry is...
Ischemic stroke, a major cause of disability and death worldwide, lacks effective treatments due to the complexity brain ischemia/reperfusion (I/R) injury. The transient receptor potential melastatin 2 (TRPM2) channel is promising therapeutic target. In this study, an extracellular TRPM2 inhibitor A1 with indolizine scaffold was identified through chemical library screening. Four series derivatives were synthesized, yielding four compounds inhibitory activity comparable or superior A1, as...
The Pictet-Spenglerase strictosidine synthase (STR1) has been recognized as a key enzyme in the biosynthesis of some 2000 indole alkaloids plants, with high therapeutic value. In this study, novel function STR1 detected which allows for first time simple enzymatic synthesis analogue 3 harboring piperazino[1,2-a]indole (PI) scaffold and to switch from common tryptoline (hydrogenated carboline) rare PI skeleton. Insight into reaction is provided by X-ray crystal analysis modeling ligand...
Acute kidney injury (AKI) is characterized by an abrupt decline in renal function, resulting inability to secrete waste products and maintain electrolyte water balance, associated with high risks of morbidity mortality. This study retrospectively analyzed clinical data, treatment, prognosis 271 hospitalized patients (172 males 99 females) diagnosed AKI from December, 2008 2011. In addition, this explored the association between cause prognosis, severity treatment AKI. The was classified...
Five series of heterocycles with extraordinary structural diversity have been regiospecifically synthesized from the same Morita–Baylis–Hillman Acetates (MBHAs). All four potential electrophilic sites (α, β, γ, δ) MBHAs are proved to be reactive.
Strictosidine synthase (STR1) catalyzes a Pictet–Spengler reaction (PSR) forming strictosidine, likely biosynthetic key to all higher plant monoterpenoid indole alkaloids. Increasing the biocatalytic capacity of enzyme may make it powerful tool for generation compound libraries with enhanced structural diversity and pharmaceutical activity. Herein two production routes rare class azepino[3,4,5-cd]-indoles are developed: complementary STR1-dependent chemoenzymatic stereoselectively chemical...
The promising application of deuterium-labeled compounds, such as the drug deutetrabenazine, warrants efficient, selective, and direct deuteration organic entities. Here, we present a highly effective regioselective C–H indole in D2O using Cp*Co(CO)I2, [Cp*RhCl2]2, or their combination catalyst. This transition-metal-catalyzed system made available mono(C2)-, di(C2/C7)-, tri(C2/C3/C7)-, even C4-deuterated products from diverse substrates, equipped with removable N1-directing group. selective...
Pd(II)-catalyzed oxidation of terminal olefins to methyl ketones has emerged as an attractive strategy for organic synthesis. Here we report the selective using tert-butyl hydroperoxide oxidant and 2-(1H-indazol-1-yl)quinoline ligand. A wide range were well tolerated in this reaction system provide ketones, whereas presence Ac2O initiated oxo-acyloxylation afford α-acetoxyacetone products. Isotope labeling studies active-intermediate-capture experiments performed elucidate underlying...
Lung cancer is one of the most common malignancies worldwide. Non-small-cell lung (NSCLC) accounts for more than 80% cancers, shows chemotherapy resistance, metastasis, and relapse. The phosphatidylinositol-3 kinase (PI3K)/Akt pathway has been implicated in carcinogenesis disease progression NSCLC, suggesting that it may be a promising therapeutic target therapy. Although phenylurea derivatives have reported as potent multiple inhibitors, novel unsymmetrical N,N'-diarylurea targeting...
A novel and efficient reaction for the synthesis of 2-keto-5-aminooxazoles is developed. The entire sequence realized by simply heating a xylene solution α-diazocarbonyl esters α-isocyanoacetamides without any promoters. possible mechanism proposed.