A5073235303- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Genomics, phytochemicals, and oxidative stress
- Central Venous Catheters and Hemodialysis
- Kidney Stones and Urolithiasis Treatments
- Advanced Glycation End Products research
- Autoimmune Bullous Skin Diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Urological Disorders and Treatments
- Platelet Disorders and Treatments
- Genetic Syndromes and Imprinting
- Diabetes Treatment and Management
- Heavy Metal Exposure and Toxicity
- Cancer-related molecular mechanisms research
- Erythropoietin and Anemia Treatment
- Epigenetics and DNA Methylation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Renal Transplantation Outcomes and Treatments
- Trace Elements in Health
- Glutathione Transferases and Polymorphisms
- Vasculitis and related conditions
- Bone and Dental Protein Studies
- Retinal Diseases and Treatments
- Botanical Studies and Applications
Second Affiliated Hospital of Jilin University
2014-2024
Jilin University
2006-2018
Jilin City Central Hospital
2016
First Bethune Hospital of Jilin University
2014
Pediatric Nephrology of Alabama
2013
Cancer cells typically display higher than normal levels of reactive oxygen species (ROS), which may promote cancer development and progression but also render the more vulnerable to further ROS insult. Indeed, many current anticancer therapeutics kill via induction oxidative stress, though they target both cells. Recently, alantolactone (ATL), a natural sesquiterpene lactone, has been shown induce apoptosis by increasing specifically in cells; however, molecular mechanisms linking...
<h3>Importance</h3> Lupus nephritis (LN) is typically treated with intravenous cyclophosphamide (IVCY), which associated serious adverse effects. Tacrolimus may be an alternative for initial treatment of LN; however, large-scale, randomized clinical studies tacrolimus are lacking. <h3>Objective</h3> To assess efficacy and safety vs IVCY as therapy LN in China. <h3>Design, Setting, Participants</h3> This (1:1), open-label, parallel-controlled, phase 3, noninferiority trial recruited patients...
Oxidative stress plays an important role in diabetes-induced vascular inflammation and pathogenesis. Nuclear factor E2-related factor-2 (Nrf2) is a transcription orchestrating antioxidant cyto-protective responses to oxidative stress. In the present study, we tested whether sulforaphane (SFN) can protect aorta from diabetes and, if so, aortic protection associated with up-regulation of Nrf2 its down-stream antioxidants.Type 1 was induced FVB mice by multiple low-dose streptozotocin. Diabetic...
To investigate the clinical and histopathological features of non-diabetic renal disease (NDRD) superimposed on diabetic nephropathy (DN) in northeastern Chinese patients with type 2 diabetes mellitus (T2D), compare changes those pure DN isolated NDRD.Single-center retrospective analysis based medical records 273 (172 men, mean age: 51.1 ± 12.4 years) T2D who underwent biopsy between February 2000 October 2015. All were diagnosed as cases DN, NDRD or DN.Out patients, 68 (24.9 %) had 175...
Diabetic patients have a high risk of pulmonary disorders that are usually associated with restrictive impairment lung function, suggesting fibrotic process (van den Borst B, Gosker HR, Zeegers MP, Schols AM. Chest 138: 393-406, 2010; Ehrlich SF, Quesenberry CP Jr, Van Den Eeden SK, Shan J, Ferrara A. Diabetes Care 33: 55-60, 2010). The present study was undertaken to define whether and how diabetes causes fibrosis. Lung samples from streptozotocin-induced type 1 diabetic mice, spontaneously...
Zinc (Zn) is an important nutrient that involved in various physiological metabolisms. Zn dyshomeostasis often associated with pathogeneses of chronic diseases, such as metabolic syndrome, diabetes, and related complications. present ocular tissue high concentrations, particularly the retina choroid. deficiencies have been shown to affect development, cataracts, age-related macular degeneration, even diabetic retinopathy. However, mechanism by which deficiency increases prevalence...
BACKGROUND:Data on the expression of RCC tissues from GEO database and patient survival data TCGA were used to explore prognostic significance long noncoding RNA SNHG1. SNHG1 has been reported participate in development several cancers, but, underlying mechanism renal cell carcinoma (RCC) not reported. The purpose our study was investigate potential function RCC. MATERIAL AND METHODS:The 40 cases adjacent normal 5 lines detected by qRT-PCR. Cell proliferation, Transwell assay, Western...
Patients on hemodialysis have a high-mortality risk. This study analyzed factors associated with death in patients maintenance (MHD). While some studies used baseline data of MHD patients, this the most recent obtained from just prior to either primary endpoint or end period find characteristics preceding death.Participants were selected 16 blood purification centers China January 2012 December 2014. Patients' collected retrospectively. Based survival status, participants divided into two...
Objective Obesity, particularly child obesity, is one of the most common public health problems in world and raises risk end‐stage renal disease. Zinc (Zn) essential for multiple organs terms normal structure function; however, effects Zn deficiency or supplementation among young individuals with obesity have not been well studied. Methods Weaned mice were fed high‐fat diets (HFD) varied contents (Zn deficient, adequate, supplemented) 3 6 months. This study examined associations between...
Whether automated peritoneal dialysis (APD) is a feasible strategy for urgent-start (PD) therapy during the break-in period remains unclear. This study was conducted to compare efficacy as well complications among three PD modes period. Ninety-six patients treated with after catheterization were retrospectively analyzed. Patients divided into groups, incremental continuous ambulatory (CAPD) group (n = 26); APD 42); and APD–CAPD 28). Clinical parameters at end of 1 month initiation treatment...
<b><i>Objective:</i></b> Tacrolimus has been used for idiopathic membranous nephropathy (IMN) therapy, but most patients who achieved remission showed a high relapse rate when tacrolimus was withdrawn after 6-12 months of therapy. We proposed that prolonged therapeutic course should help reduce the rate. <b><i>Methods:</i></b> A total 42 with nephrotic syndrome caused by IMN were randomly divided into short-term (n = 20) and long-term 22)...
The present study tested whether MG132 increases vascular nuclear factor E2-related factor-2 (Nrf2) expression and transcription to provide a therapeutic effect on diabetes-induced pathogenic changes in the aorta. To this end, three-month-old OVE26 diabetic age-matched control mice were intraperitoneally injected with MG-132, 10 μ g/kg daily for 3 months. transgenic type 1 develop hyperglycemia at 2-3 weeks of age exhibit albuminuria months mild TNF- α 3-NT accumulation Diabetes-induced...