A5100653635- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Blood Pressure and Hypertension Studies
- Systemic Lupus Erythematosus Research
- IgG4-Related and Inflammatory Diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Erythropoietin and Anemia Treatment
- Sirtuins and Resveratrol in Medicine
- Renin-Angiotensin System Studies
- Iron Metabolism and Disorders
- Trace Elements in Health
- Galectins and Cancer Biology
- Adipokines, Inflammation, and Metabolic Diseases
- Sodium Intake and Health
- Heavy Metal Exposure and Toxicity
- Autophagy in Disease and Therapy
- Chronic Lymphocytic Leukemia Research
- Vasculitis and related conditions
- Selenium in Biological Systems
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Artificial Intelligence in Healthcare
- Pancreatic function and diabetes
- Diet and metabolism studies
- Advanced Glycation End Products research
First Hospital of Jilin University
2016-2025
Jilin University
2016-2025
National Natural Science Foundation of China
2020
Weatherford College
2020
Second Affiliated Hospital of Jilin University
2006-2012
City of Hope
2005-2008
Beckman Research Institute
2005-2008
Diabetes Research Center
2008
Hospital Universitario de Maracaibo
2005
University of California, Irvine
2005
MDSCs promote T H 17 differentiation and systemic lupus erythematosus via arginase-1 production in patients humanized mice.
<h3>Importance</h3> Lupus nephritis (LN) is typically treated with intravenous cyclophosphamide (IVCY), which associated serious adverse effects. Tacrolimus may be an alternative for initial treatment of LN; however, large-scale, randomized clinical studies tacrolimus are lacking. <h3>Objective</h3> To assess efficacy and safety vs IVCY as therapy LN in China. <h3>Design, Setting, Participants</h3> This (1:1), open-label, parallel-controlled, phase 3, noninferiority trial recruited patients...
Farnesoid X receptor (FXR) (nuclear subfamily 1, group H, member 4) is a of nuclear hormone superfamily, which plays essential roles in metabolism bile acids, lipid, and glucose. We previously showed spontaneously hepatocarcinogenesis aged FXR(-/-) mice, but its relevance to human hepatocellular carcinoma (HCC) unclear. Here, we report systematical analysis mice FXR expression liver cancer. In this study, tissues obtained from wild-type at different ages were compared by microarray gene...
Abstract Diabetic nephropathy (DN) is one of the most serious complications diabetes and main cause end-stage renal failure. Rhubarb a widely used traditional Chinese herb, it has exhibited efficacy in reducing proteinuria, lowering blood sugar levels improving kidney function patients with DN. However, exact pharmacological mechanism by rhubarb improves DN remain unclear due to complexity its ingredients. Hence, we systematically explored underlying mechanisms treatment We adopted network...
The simultaneous occurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) and light chain proximal tubulopathy (LCPT) presents a unique diagnostic therapeutic challenge. PGNMID is characterized by deposition in glomeruli, leading to glomerular pathology, while LCPT involves tubular cells, causing tubulointerstitial damage. Both conditions are classified under gammopathy renal significance (MGRS), but their coexistence single patient exceedingly rare....
Hemodialysis is the primary life-sustaining treatment for patients with end-stage kidney disease, which can result in a range of negative reactions (e.g. depression and anxiety) positive change post-traumatic growth, PTG). To further understand response patterns who are going through hemodialysis, dividing them into homogeneous subgroups helps to uncover hidden information. This cross-sectional study evaluated 274 (172 males 102 females) undergoing hemodialysis at tertiary hospital between...
Many studies have suggested that gut microbiota dysbiosis may be one of the pathogenesis factors diabetes mellitus (DM), while it is not clear whether involved in development diabetic kidney diseases (DKD). The objective this study was to determine bacterial taxa biomarkers during progression DKD by investigating compositional changes early and late DKD. 16S rRNA gene sequencing performed on fecal samples, including DNa (early DKD), DNb (late DKD) groups. Taxonomic annotation microbial...
Lupus nephritis (LN) is one of the most severe complications systemic lupus erythematosus (SLE). However, current management LN remains unsatisfactory due to sneaky symptoms during early stages and lack reliable predictors disease progression.Bioinformatics machine learning algorithms were initially used explore potential biomarkers for development. Identified biomarker expression was evaluated by immunohistochemistry (IHC) multiplex immunofluorescence (IF) in 104 patients, 12 diabetic...
There is currently no research on the correlation between novel inflammatory indexes systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), and risk of anemia in chronic kidney disease (CKD) population, as well survival analysis CKD with anemia.
Diabetic kidney disease (DKD) is the leading cause of chronic and end-stage renal worldwide. Early diagnosis critical to prevent its progression. The aim this study was identify potential diagnostic biomarkers for DKD, illustrate biological processes related investigate relationship between them immune cell infiltration. Gene expression profiles (GSE30528, GSE96804, GSE99339) samples obtained from DKD controls were downloaded Expression Omnibus database as a training set, gene (GSE47185...
Angiotensin II and its type 1 receptor (AT1R) play important roles in the pathogenesis of renal disease diabetic nephropathy. The 12/15-lipoxygenase pathway arachidonate metabolism lipid products have also been implicated However, it is unclear whether regulates expression AT1R. In cultured rat mesangial cells, we found that product 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) increased AT1R mRNA protein expression, primarily by stabilizing mRNA. Pretreatment with 12(S)-HETE amplified...
Background. Proteinuria is a cardinal feature of glomerular disease, including diabetic nephropathy, and the filtration barrier acts as filter, restricting protein excretion in urine. We tested whether expression P-cadherin, molecule known to be located at slit diaphragm, was altered by diabetes vivo high glucose vitro.