A5038538824- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Liver Disease Diagnosis and Treatment
- Selenium in Biological Systems
- Trace Elements in Health
- Birth, Development, and Health
- Machine Learning in Healthcare
- Immunotherapy and Immune Responses
- Phytochemistry and biological activity of medicinal plants
- Parathyroid Disorders and Treatments
- Biochemical Acid Research Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Immune Cell Function and Interaction
- Pharmacological Effects of Natural Compounds
- Heavy Metal Exposure and Toxicity
- interferon and immune responses
- Natural product bioactivities and synthesis
- Systemic Sclerosis and Related Diseases
- Metabolism, Diabetes, and Cancer
- Liver Diseases and Immunity
- Microbial Natural Products and Biosynthesis
- Galectins and Cancer Biology
- Hematopoietic Stem Cell Transplantation
Jilin University
2021-2025
First Hospital of Jilin University
2021-2025
Abstract Diabetic nephropathy (DN) is one of the most serious complications diabetes and main cause end-stage renal failure. Rhubarb a widely used traditional Chinese herb, it has exhibited efficacy in reducing proteinuria, lowering blood sugar levels improving kidney function patients with DN. However, exact pharmacological mechanism by rhubarb improves DN remain unclear due to complexity its ingredients. Hence, we systematically explored underlying mechanisms treatment We adopted network...
Lupus nephritis (LN) is one of the most severe complications systemic lupus erythematosus (SLE). However, current management LN remains unsatisfactory due to sneaky symptoms during early stages and lack reliable predictors disease progression.Bioinformatics machine learning algorithms were initially used explore potential biomarkers for development. Identified biomarker expression was evaluated by immunohistochemistry (IHC) multiplex immunofluorescence (IF) in 104 patients, 12 diabetic...
Prior research has identified associations between immune cells and aplastic anaemia (AA); however, the causal relationships them have not been conclusively established. A two-sample Mendelian randomisation analysis was conducted to investigate link 731 cell signatures AA risk using publicly available genetic data. Four types of signatures, including relative cell, absolute (AC), median fluorescence intensities morphological parameters, were considered sensitivity analyses also performed...
Diabetic kidney disease (DKD) is the leading cause of chronic and end-stage renal worldwide. Early diagnosis critical to prevent its progression. The aim this study was identify potential diagnostic biomarkers for DKD, illustrate biological processes related investigate relationship between them immune cell infiltration. Gene expression profiles (GSE30528, GSE96804, GSE99339) samples obtained from DKD controls were downloaded Expression Omnibus database as a training set, gene (GSE47185...
Renal biopsy is the gold standard for Immunoglobulin A nephropathy (IgAN) but poses several problems. Thus, we aimed to establish a noninvasive model predicting risk probability of IgAN by analyzing routine and serological parameters. total 519 biopsy-diagnosed 211 non-IgAN patients were recruited retrospectively. Artificial neural networks logistic modeling used. The receiver operating characteristic (ROC) curve performance characteristics determined compare diagnostic value between two...
Introduction IgA nephropathy (IgAN), a prevalent form of glomerulonephritis globally, exhibits complex pathogenesis. Cathepsins, cysteine proteases within lysosomes, are implicated in various physiological and pathological processes, including renal conditions. Prior observational studies have suggested potential link between cathepsins IgAN, yet the precise causal relationship remains unclear. Methods We conducted comprehensive bidirectional multivariable Mendelian randomization (MR) study...
Patients with diabetic kidney disease (DKD) often have gastrointestinal dysfunction such as inflammatory bowel (IBD). This study aims to investigate the genetic mechanism leading IBD in DKD patients through data mining and bioinformatics analysis. The disease-related genes of were searched from five databases OMIM, GeneCards, PharmGkb, TTD, DrugBank, intersection part two diseases taken obtain risk complicated IBD. A protein-protein interaction (PPI) network analysis was performed on genes,...
Background Systemic lupus erythematosus (SLE), a multisystemic autoimmune disease, is very aggressive in pediatric-onset patients as they are prone to develop nephritis (LN). Although renal C4d positivity correlated with the activity of disease and SLE adult-onset LN patients, available information for limited. Methods To evaluate potential diagnostic significance staining pediatric we retrospectively detected by immunohistochemistry on biopsy specimens from 58 patients. The clinical...
Osteosarcoma (OS) is the most common type of primary bone tumor in children and adults. Dangshen (Codonopsis pilosula) a traditional Chinese medicine commonly used treatment OS worldwide. However, molecular mechanisms remain unclear. Hence, this study, we aimed to systematically explore underlying OS. Our study adopted network pharmacology approach, focusing on identification active ingredients, drug target prediction, gene collection, ontology (GO) enrichment, Kyoto Encyclopedia Genes...
The relationship between selenium and renal function has always attracted widespread attention. Increased level been found to cause impaired in our previous study, but the mechanism is not clear. In this we evaluate potential mediating effects of plasma proteome association understand mechanisms selenium's effect on function.
Rationale: The causal relationship between anti-glomerular basement membrane (anti-GBM) disease and immunoglobulin A (IgA) nephropathy is still unclear cases of concurrent anti-GBM IgA are very rare, especially with a good prognosis long-term follow-up. Here, we report case nephropathy. By using corticosteroids cyclophosphamide in combination plasmapheresis, the patient achieved complete normalization renal function disappearance hematuria proteinuria at subsequent To our knowledge, no...
Abstract Background : Primary membranous nephropathy (PMN) refers to an immune complex-mediated cause of the nephrotic syndrome, which is one leading causes end-stage renal disease worldwide and imposes a heavy burden on patients with PMN medical insurance system. The risk complications unsatisfied efficacy limit use traditional diagnostic methods in some patients. Thus discovery novel biomarkers needed. aim present study was identify potential for revealing significance cell infiltration...