A5102862507- Cancer Immunotherapy and Biomarkers
- Renal Diseases and Glomerulopathies
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Chronic Kidney Disease and Diabetes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Plant Stress Responses and Tolerance
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Cutaneous Melanoma Detection and Management
- IgG4-Related and Inflammatory Diseases
- Systemic Lupus Erythematosus Research
- Silicon Effects in Agriculture
- Immune Cell Function and Interaction
- Vasculitis and related conditions
- Reproductive System and Pregnancy
- Mycobacterium research and diagnosis
- Parathyroid Disorders and Treatments
- Lung Cancer Research Studies
- Renal Transplantation Outcomes and Treatments
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Plant Molecular Biology Research
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
First Hospital of Jilin University
2016-2025
Jilin University
2016-2025
Peking University
2018-2024
Peking University Third Hospital
2021-2024
Guangxi University
2023-2024
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2023-2024
Yangtze River Pharmaceutical Group (China)
2024
Tianjin Agricultural University
2024
University of Macau
2022
Weatherford College
2020-2022
MDSCs promote T H 17 differentiation and systemic lupus erythematosus via arginase-1 production in patients humanized mice.
PD-1 checkpoint blockade immunotherapy induces long and durable response in patients with advanced melanoma. However, only a subset of melanoma benefit from this approach. The mechanism triggering the innate resistance anti-PD-1 therapy remains unclear.Experimental Design: Whole-exome sequencing (WES) RNA (RNA-Seq) analyses were performed training cohort (n = 31) using baseline tumor biopsies treated antibody. Copy-number variations (CNVs) for genes CDK4, CCND1, CDKN2A assayed TaqMan...
Immune checkpoint inhibitor (ICI) treatments produce clinical benefit in many patients. However, better pretreatment predictive biomarkers for ICI are still needed to help match individual patients the treatment most likely be of benefit. Existing gene expression profiling (GEP)-based primarily focused on measuring a T cell-inflamed tumor microenvironment that contributes positively response ICI. Here, we identified an immunosuppression signature (IMS) through analyzing RNA sequencing data...
Chronic interstitial fibrosis presents a significant challenge to the long-term survival of transplanted kidneys. Our research has shown that reduced expression acyl-coenzyme A oxidase 1 (ACOX1), which is rate-limiting enzyme in peroxisomal fatty acid β-oxidation pathway, contributes development renal allografts. ACOX1 deficiency leads lipid accumulation and excessive oxidation polyunsaturated acids (PUFAs), mediate epithelial-mesenchymal transition (EMT) extracellular matrix (ECM)...
Podocytes are terminally differentiated cells lining the Bowman's capsule. critical for proper glomerular filtration barrier function. At same time, autophagy is crucial maintaining podocyte homeostasis and insufficient could cause loss proteinuria that commonly observed in diabetic nephropathy (DN).In this study, we investigated role of spironolactone autophagy. DN model was established male Sprague-Dawley rats using high-fat diet low-dose streptozotocin. The impact on metabolic biochemical...
Fenofibrate (FF) protects against diabetic nephropathy (DN) in type 1 (T1D) mice by upregulating the expression of fibroblast growth factor 21 (FGF21), leading to activation Akt-mediated Nrf2 antioxidant pathways. Here, we examined which isoforms Akt contribute FF FGF21-mediated renal protection examining phosphorylation and three isoforms, Akt1, Akt2, Akt3. T1D induced a single intraperitoneal dose streptozotocin (STZ) resulted reduced one isoform, but treatment increased Akt2 these normal...
The Casparian strip (CS) is a ring-like lignin structure deposited between endodermal cells that forms an apoplastic barrier to control the selective uptake of nutrients in vascular plants. However, molecular mechanism CS formation rice (Oryza sativa), which possesses one each endodermis and exodermis, relatively unknown. Here, we functionally characterized INTEGRITY FACTOR1 (OsCIF1a, OsCIF1b), OsCIF2, SCHENGEN3 (OsSGN3a, OsSGN3b) rice. OsCIF1s OsCIF2 were mainly expressed stele, while...
The simultaneous occurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) and light chain proximal tubulopathy (LCPT) presents a unique diagnostic therapeutic challenge. PGNMID is characterized by deposition in glomeruli, leading to glomerular pathology, while LCPT involves tubular cells, causing tubulointerstitial damage. Both conditions are classified under gammopathy renal significance (MGRS), but their coexistence single patient exceedingly rare....
Background Lupus nephritis (LN) emerges as a severe complication of systemic lupus erythematosus (SLE), significantly affecting patient survival. Despite improvements in treatment reducing LN's morbidity and mortality, existing therapies remain suboptimal, emphasizing the necessity for early detection to improve outcomes.
// Chuanxi Wang 1 , Jinyu Yu Yuping Han 2 Leping Li 3 Jie 4 Tao Peng Qi 5, 6, 7 Department of Oncology, Shandong Provincial Hospital Affiliated to University, Jinan, Province, China Emergency, affiliated Gastrointestinal Surgery, Infectious Diseases, 5 Pathology, Fudan University Shanghai Cancer Center, Fudan, Shanghai, 6 Medical College, Institute Correspondence to: Qi, email: qjpeng1225@126.com Keywords: long non-coding RNA, serum, colorectal cancer, biomarker Received: March 28,...
The hemoglobin, albumin, lymphocyte, and platelet (HALP) score, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR) are the important prognostic markers in some tumor types. This study aimed to evaluate impact of pretreatment using HALP, NLR, PLR for patients with small-cell lung cancer (SCLC), who were undergoing chemotherapy.In this retrospective study, 335 SCLC included between 2016 2018. cutoff values defined X-tile software. Survival was analyzed by Kaplan-Meier method,...
Lupus nephritis (LN) is one of the most severe complications systemic lupus erythematosus (SLE). However, current management LN remains unsatisfactory due to sneaky symptoms during early stages and lack reliable predictors disease progression.Bioinformatics machine learning algorithms were initially used explore potential biomarkers for development. Identified biomarker expression was evaluated by immunohistochemistry (IHC) multiplex immunofluorescence (IF) in 104 patients, 12 diabetic...
Abstract In response to variable environments, rice (Oryza sativa) roots have developed lignified and suberized diffusion barriers at the endodermis permit selective nutrient uptake for optimal growth. Here, we demonstrate that endodermal suberization nonlocalized lignification are redundantly regulated by 4 MYB transcription factors: OsMYB39a, OsMYB41, OsMYB92a, OsMYB92b. These factors function downstream of OsMYB36a/b/c, CASPARIAN STRIP INTEGRITY FACTOR (OsCIF)–SCHENGEN3 (OsSGN3),...
Scavenger receptor class B type I (SR-B1) is highly expressed in a variety of cancers, including prostate, breast and ovarian. However, the relationship between SR-B1 lung adenocarcinoma unknown. We analyzed expression well-characterized tissue microarray by immunohistochemistry, 90 cancerous adjacent normal tissues. Results showed that positive rate cancer tissues (86/90, 96%) was significantly higher than (50/90, 56%) (P < .001). And overexpression .001), accounting for 67% cases. This...
Myeloid-derived suppressor cells (MDSCs) are a group of immature myeloid that play an important role in diseases. MDSCs promote Th17 differentiation and aggravate systemic lupus erythematosus (SLE) progression by producing arginase-1 to metabolize arginine. However, the metabolic regulators remain unknown. Here, we report MDSC derivative polyamines can via miR-542–5p vitro. polarization was enhanced response polyamine treatment or upon overexpression. The TGF-β/SMAD3 pathway shown be...
Rice (Oryza sativa) exhibits tremendous aluminum (Al)-tolerance. The C2H2-transcription factor (TF) ART1 critically regulates rice Al tolerance via modulation of specific gene expression. However, little is known about the posttranscriptional regulation. Here, we identified an ART1-interacted OsNAC016 a yeast two-hybrid (Y2H) assay. was primarily expressed in roots and weakly induced by Al. Immunostaining showed that nuclear protein localized all root cells. Knockout did not alter...
Many studies have confirmed that myeloid-derived suppressor cells (MDSCs) are closely related to autoimmune diseases, but their exact role in these processes remains largely unclear. Here, we investigate this question patients with primary membranous nephropathy (PMN). Compared healthy controls (HCs), PMN showed a significantly increased number of HLA-DR−CD11b+CD33+ MDSCs the peripheral blood, including both CD14+CD66b− monocytic and CD14−CD66b+ granulocytic MDSCs. The frequency was...
Diabetic kidney disease (DKD) is the leading cause of chronic and end-stage renal worldwide. Early diagnosis critical to prevent its progression. The aim this study was identify potential diagnostic biomarkers for DKD, illustrate biological processes related investigate relationship between them immune cell infiltration. Gene expression profiles (GSE30528, GSE96804, GSE99339) samples obtained from DKD controls were downloaded Expression Omnibus database as a training set, gene (GSE47185...
The aim of this study is to identify a gene prognostic signature for the head-and-neck squamous cell carcinoma (HNSCC). HNSCC one most common malignancies worldwide; however, molecular mechanisms underlying malignancy are unclear.We analyzed expression profiles GSE2379, GSE53819, and GSE59102 derived from omnibus, cancer genome atlas (TCGA) HNSC databases. R software was used differentially expressed genes (DEGs) between tissues normal controls. Gene ontology, Kyoto Encyclopedia Genes...