A5019005904- Monoclonal and Polyclonal Antibodies Research
- Advanced Biosensing Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Radiopharmaceutical Chemistry and Applications
- HER2/EGFR in Cancer Research
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Cutaneous Melanoma Detection and Management
- Immune cells in cancer
- CAR-T cell therapy research
- Click Chemistry and Applications
- bioluminescence and chemiluminescence research
- RNA Interference and Gene Delivery
- Cancer Research and Treatments
- Peptidase Inhibition and Analysis
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
- Chemical Synthesis and Analysis
- Lung Cancer Treatments and Mutations
- RNA regulation and disease
- Ferroptosis and cancer prognosis
- Prostate Cancer Treatment and Research
- Glycosylation and Glycoproteins Research
Peking University Cancer Hospital
2019-2025
Peking University
2019-2025
Fourth Affiliated Hospital of Guangxi Medical University
2023-2025
Guiyang University
2025
First Affiliated Hospital of Zhengzhou University
2024
Zhengzhou University
2024
Liuzhou Maternal and Child Health Hospital
2024
Guizhou University
2022-2023
National Medical Products Administration
2022-2023
Guiyang Medical University
2022-2023
PD-1 checkpoint blockade immunotherapy induces long and durable response in patients with advanced melanoma. However, only a subset of melanoma benefit from this approach. The mechanism triggering the innate resistance anti-PD-1 therapy remains unclear.Experimental Design: Whole-exome sequencing (WES) RNA (RNA-Seq) analyses were performed training cohort (n = 31) using baseline tumor biopsies treated antibody. Copy-number variations (CNVs) for genes CDK4, CCND1, CDKN2A assayed TaqMan...
Prostate-specific membrane antigen (PSMA) is a prostate cancer target that plays crucial role in diagnosis and therapy. Herein, novel dual-targeted imaging probe, [68Ga]Ga-FAPI-PSMA, was prepared by radiolabeling conjugated DOTA-FAPI-PSMA with the short half-life radionuclide gallium-68 (68Ga), which dedicated to diagnostic imaging. In vitro, [68Ga]Ga-FAPI-PSMA had higher affinity for PSMA FAP high-expressing cell lines 22Rv1 U87 MG IC50 values of 4.73 2.10 nM, respectively, than...
Vitellogenin (Vg) and the vitellogenin receptor (VgR) play essential roles in insect reproductive development. However, functions of Vg VgR genes Lasioderma serricorne, an important pest stored products, are unknown. We identified characterized these two genes, designated LsVg LsVgR, L. serricorne. The open reading frames LsVgR were 5232 5529 bp, encoding 1743 1842 amino acid residues, respectively. Both predominantly expressed female adults exhibited highest expression ovaries....
Amino acid metabolism (AAM) reprogramming plays a crucial role in hepatocellular carcinoma (HCC), but its genetic pathophysiology was not fully elucidated. Therefore, we employed summary data-based Mendelian randomization (SMR) approach to identify putative causal effects of the AAM-related genes on hepatitis B virus (HBV)-HCC survival via integrating multi-omics data. Multivariate Cox proportional hazards regression models were used evaluate associations between variants and overall (OS)...
Abstract Background Single-cell technologies have enabled extensive analysis of complex immune composition, phenotype and interactions within tumor, which is crucial in understanding the mechanisms behind cancer progression treatment resistance. Unfortunately, knowledge on cell phenotypes their spatial has only had limited impact pathological stratification patients clinic so far. We explore relationship between different tumor environments (TMEs) response to immunotherapy by deciphering...
Real-time monitoring of the biological behavior extracellular vesicles (EVs) in vivo is limited, which hinders its application biomedicine and clinical translation. A noninvasive imaging strategy could provide us with useful information on EVs' distribution, accumulation homing vivo, pharmacokinetics. In this study, long half-life radionuclide iodine-124 (124I) was used to directly label umbilical cord mesenchymal stem cell-derived EVs. The resulting probe, namely, 124I-MSC-EVs, manufactured...
Abstract Background Melanoma is a type of malignant tumor with high aggressiveness and poor prognosis. At present, metastasis melanoma still an important cause death in patients. However, the potential functions molecular mechanisms most circular RNAs (circRNAs) remain unknown. Methods circRNAs dysregulated cell subgroups different metastatic abilities according to screening model based on repeated Transwell assays were identified circRNA array. The expression prognostic significance...
Conventional chemotherapy is commonly used to treat non-small cell lung cancer (NSCLC) however it increases therapeutic resistance. In contrast, metronomic (MET) based on frequent drug administration at lower doses, resulting in inhibition of neovascularization and induction tumor dormancy. This study aims evaluate the inhibitory effects, adverse events, potential mechanisms MET Vinorelbine (NVB) combined with an angiogenesis inhibitor (Endostar).Circulating endothelial progenitor cells...
DNA methylation inhibitors (azacitidine, decitabine) have revolutionized the treatment dilemma of myelodysplastic syndromes (MDS), a group malignant hematopoietic disorders. This study evaluates adverse drug reactions (ADRs) following use in World Health Organization (WHO) VigiAccess database and compares characteristics ADRs between two drugs to select with minimum individualized risk for patients.
Recent advances in targeted therapy and immunotherapy have substantially improved the treatment of melanoma. However, therapeutic strategies are still needed for unresponsive or treatment-relapsed patients with To discover antibody-drug conjugate (ADC)-tractable cell surface targets melanoma, we developed an atlas melanoma surface-binding antibodies (pAb) using a proteome-scale antibody array platform. Target identification pAbs led to development killing ADCs against LGR6, TRPM1, ASAP1,...
is a suppressor gene closely related to carcinogenesis. However, the associations between genetic variants in p53 signaling pathway and prognosis hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remain unknown. The current study aims analyze single nucleotide polymorphisms (SNPs) pathway-related genes survival of patients with HBV-HCC.
Antitumor medications such as Avastin, Berubicin, and Temozolomide have fundamentally transformed the treatment landscape for gliomas by exhibiting potent pharmacological effects on both high-grade low-grade gliomas. This study aims to determine which anti-glioma medication presents lowest risk personalized use in clinical patients assessing adverse drug reactions (ADRs) associated with these reported World Health Organization (WHO) VigiAcess database, comparing characteristics of responses...
Background and objectives Isocitrate dehydrogenase (IDH) inhibitor drugs (Enasidenib, Ivosidenib) restore normal metabolism epigenetic regulation in cells, offering a precision-targeted therapeutic option for acute myeloid leukemia (AML) patients with IDH mutations by specifically inhibiting mutated enzymes. This research evaluates the relationship between adverse drug reactions (ADR) use of two isocitrate inhibitors using database from World Health Organization (WHO) VigiAccess compares...
Super-enhancer (SE) refers to a regulatory element with super transcriptional activity, which can enrich transcription factors and drive gene expression. SE-related genes play an important role in the pathogenesis of malignant tumors, including hepatocellular carcinoma (HCC).The were obtained from human super-enhancer database (SEdb). Data transcriptome analysis related clinical information HCC The Cancer Genome Atlas (TCGA) International Consortium (ICGC) database. upregulated TCGA-LIHC...
Background: Renal cell carcinoma (RCC) is a common malignancy of the genitourinary system and clear renal (ccRCC) most representative subtype. The morbidity mortality ccRCC have gradually risen during recent years; however, pathogenesis potential biomarkers remain unclear. purpose our study was to find out prognostic genes correlated with somatic mutation underlying mechanisms HMCN1 in ccRCC. Methods: Somatic data two cohorts were acquired from TCGA cBioPortal. Genes frequently mutated both...
Programmed cell death-ligand 2 (PD-L2) is an important emerging molecule of the immune checkpoint, which closely related to prognosis patients with checkpoint inhibitor (ICI) therapy. The quantification PD-L2 can provide a potential reference for who benefit from ICI treatment. In this study, we used iodine isotope (nat/124/125I)-labeled antibody (ATL2) noninvasively detect expression in mice human lung adenocarcinoma A549 lines. radiochemical yields 125I-ATL2 and 124I-ATL2 were 73.56 ±...
This study aimed to introduce a novel [18F]AlF-labeled ODAP-Urea-based Prostate-specific membrane antigen (PSMA) probe, named [18F]AlF-PSMA-137, which was derived from the successful modification of glutamate-like functional group. The preclinically physical and biological characteristics probe were analyzed. Polit clinical PET/CT translation performed analyze its feasibility in diagnosis prostate cancer. [18F]AlF-PSMA-137 maturely labeled with [18F]AlF2+ labeling technique. It analyzed by...
Abstract Telomerase reverse transcriptase (TERT) copy number gain is frequently observed in Asian melanoma patients. Here, we explored the correlation between TERT and effect of telomerase inhibitors melanoma. A total 78 cases were enrolled study. The was examined by QuantiGene Plex DNA assay. sensitivity to evaluated cell lines patient-derived xenograft (PDX) models with or without gain. Among patients, 33.3% showed gain, incidence this acral (61.5%) higher than that other subtypes...
Activated T cells played critical roles in immunotherapy and adoptive cell therapy, a non-invasive imaging strategy can provide us useful information concerning the transportation, accumulation, homing of vivo. In this paper, by utilizing long half-life radionuclide iodine-124 (124I) CD25 specific monoclonal antibody Basiliximab, we have fabricated novel probe, namely, 124I-Basiliximab, which was highly promising immuno-PET cells. vitro, 124I-Basiliximab had superior affinity to protein (Kd...
Abstract Background N7-methylguanosine (m7G) modification is an important RNA modification, which plays a key role in tumorigenesis and progression. However, few studies have explored the effects of genetic variants m7G genes on survival patients with hepatocellular carcinoma (HCC). Methods We used multivariable Cox proportional hazards regression to evaluate associations between 28 overall (OS) 866 hepatitis B virus-related (HBV-HCC) patients. Results In present study, we identified that...
<title>Abstract</title> Nucleotide excision repair (NER) is an important DNA damage pathway involved in prognosis of cancer. The aim this study was to investigate the association between genetic variants NER genes and overall survival (OS) hepatocellular carcinoma (HCC) patients. Cox proportional hazards regression analyses performed associations single nucleotide polymorphism (SNPs) candidate OS 866 patients with operable hepatitis B virus (HBV) related HCC. relationship SNPs corresponding...
Abstract Nucleotide excision repair (NER) is an important DNA damage pathway involved in prognosis of cancer. The aim this study was to investigate the association between genetic variants NER genes and overall survival (OS) hepatocellular carcinoma (HCC) patients. Cox proportional hazards regression analyses performed associations single nucleotide polymorphism (SNPs) candidate OS 866 patients with operable hepatitis B virus (HBV) related HCC. relationship SNPs corresponding estimated by...