A5100393426- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Drug Transport and Resistance Mechanisms
- Genetic Mapping and Diversity in Plants and Animals
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Ruminant Nutrition and Digestive Physiology
- Advanced Breast Cancer Therapies
- Inflammatory mediators and NSAID effects
- Endometriosis Research and Treatment
- Microtubule and mitosis dynamics
- Viral-associated cancers and disorders
- Cancer-related Molecular Pathways
- Heat shock proteins research
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neural Engineering
- RNA regulation and disease
- Endometrial and Cervical Cancer Treatments
- Cancer Research and Treatments
- Cancer therapeutics and mechanisms
- Cytokine Signaling Pathways and Interactions
- Bacterial Identification and Susceptibility Testing
- PI3K/AKT/mTOR signaling in cancer
- Reproductive Physiology in Livestock
China Medical University
2023-2025
Second Affiliated Hospital of Xinjiang Medical University
2024
Xinjiang Medical University
2024
Guilin Medical University
2024
Wenzhou Medical University
2024
Ruian People's Hospital
2024
Capital Medical University
2023
Beijing Obstetrics and Gynecology Hospital
2023
South China Normal University
2022
Nanjing Medical University
2021
Inducing gamma oscillations with non-invasive light flicker has been reported to impact Alzheimer's disease-related pathology. However, it is unclear which signaling pathways are involved in reducing amyloid load. Here, we found that frequency increased anchoring of precursor protein (APP) the plasma membrane for non-amyloidogenic processing, and then physically interacted KCC2, a neuron-specific K+ -Cl- cotransporter, suggesting essential maintain surface GABAA receptor α1 levels reduce...
Abstract Significant heterogeneity exists in hormone receptor (HR)-positive/HER2-positive (HR + /HER2 ) breast cancer, contributing to suboptimal pathological complete response rates with conventional neoadjuvant treatment regimens. Overcoming this challenge requires precise molecular classification, which is pivotal for the development of targeted therapies. We conducted typing on a cohort 211 patients HR cancer and performed comprehensive analysis efficacy various Our findings revealed...
Purpose: The aim of this study was to investigate the correlations and interactions between polymorphisms insulin resistance-related genes (ADIPOQ rs2241766), inflammation factors (TNF-α rs1800629, IL-6 rs1800795), obesity-related (GNB3 rs5443, ADRB rs1042714), risk for gestational diabetes mellitus (GDM) such as diet structure in development GDM.Materials methods: This research conducted among women who visited third-affiliate hospital Zhengzhou University pregnancy checkups from 1 June...
Development of multidrug resistance (MDR) during chemotherapy is a fundamental obstacle associated with cancer care. Prior studies have identified (2-(4-methoxyphenyl)-4-quinolinyl)(2-piperidinyl)methanol (5) (NSC23925) to be small molecule agent that reverses MDR in cells. We synthesized all four isomers 5 and analyzed them by liquid chromatography-mass spectrometry (LCMS). Structure-activity relationships for reversing were evaluated. Isomer 11 demonstrated the most potent activity....
Preeclampsia (PE) is a pregnancy-specific syndrome that has severe implications on perinatal mortality and morbidity. Excessive apoptosis of trophoblasts induced by hypoxia may be associated with the development PE, but exact pathogenesis unknown. Forkhead box O transcription factor 3a (FOXO3a) activated under hypoxic conditions. Furthermore, hypoxia‑inducible factor‑1α (HIF‑1α) sensitive to variations in partial oxygen pressure. Thus, aims present study were investigate expression levels...
DNA methylation inhibitors (azacitidine, decitabine) have revolutionized the treatment dilemma of myelodysplastic syndromes (MDS), a group malignant hematopoietic disorders. This study evaluates adverse drug reactions (ADRs) following use in World Health Organization (WHO) VigiAccess database and compares characteristics ADRs between two drugs to select with minimum individualized risk for patients.
Strategies to prevent the emergence of drug resistance will increase effectiveness chemotherapy treatment and prolong survival women with ovarian cancer. The aim our study is determine effects NSC23925 on preventing development paclitaxel in cancer both cultured cells vitro mouse xenograft models vivo, further elucidate these underlying mechanisms. We first developed a paclitaxel-resistant cell line, demonstrated that could introduction by specifically inhibiting overexpression...
Cancer stem cells (CSC) typically over-express aldehyde dehydrogenase (ALDH). Thus, ALDHbright tumor represent targets for developing novel cancer prevention/treatment interventions. Loss of p53 function is a common genetic event during development wherein small molecular weight compounds (SMWC) that restore and reverse growth have been identified. Here, we focused on two widely studied SMWC, CP-31398 PRIMA-1, to target CSC in human breast, endometrial pancreas carcinoma cell lines...
Abstract Background Endometriosis, a common gynaecological disease in women, affects 10% of women childbearing age. Among infertile this proportion is as high 30–50%. Despite the prevalence endometriosis, pathogenesis endometriosis still unclear. Methods In present study, bioinformatics analysis and molecular animal experiments were employed to explore functions PCGEM1 endometriosis. We established an rat model isolated endometrial stromal cells (ESCs) primary normal ESCs (NESCs)....
Heat shock protein 70 (Hsp70), a highly conserved cellular stress protein, is produced in every organism from bacteria to man. The purpose of this study was determine the difference Hsp70 concentrations between term and preterm deliveries.In total, 30 healthy delivery 99 (PD) women were recruited, including 46 with labor intact membranes (PTL) or without an intra-amniotic infection (IAI) 53 premature rupture (PPROMs) IAI. levels maternal umbilical cord sera tested by enzyme-linked...
Abstract A colchicine-induced autotetraploid grapevine exhibiting potentially valuable agronomic traits for grape production and breeding, including self-pruning, was identified. This study investigated DNA methylation variation its role in gene expression during self-pruning the grapevine. We used RNA-Seq to estimate differentially expressed genes between diploid shoot tips. The showing increases were mainly related stress response pathways, whereas those decreases biological metabolism...
Phenylketonuria (PKU, OMIM 261600) caused by phenylalanine hydroxylase (PAH) deficiency is an autosomal recessive disease that characterized abnormalities of metabolism. In this study, a total 77 patients, originating from the central region China and who were diagnosed with PAH at third affiliated hospital Zhengzhou University, enrolled in study. The 13 exons 12 flanking introns gene analyzed Sanger sequencing next generation sequencing. data aligned to hg19, PAHvdb HGMD databases...
ObjectiveOA was generally considered as a non-inflammatory disease dominated by articular cartilage degeneration. However, the role of synovitis in OA pathogenesis has received increasing attention. Recent studies support that patients have pro-inflammatory/catabolic synovial environment similar to RA patients, promoting occurrence and development OA. Therefore, we investigated co-immune-related genes pathways explore whether part can be used explain synovitis.MethodsData GSE29746 GSE12021...
Background Coinfection with the human immunodeficiency virus (HIV) and hepatitis B (HBV) occurs in 5–67% of patients HIV. HIV weakens immune system leads to various tumors. Patients unresectable hepatocellular carcinoma (HCC) experience poor treatment efficacy have a short survival period. Approximately 70% cases HCC are diagnosed at advanced stages due subtle onset disease. As result, most not suits for curative therapy. Transcatheter arterial chemoembolization (TACE) is first-line...
Parkinson's disease (PD) is the second most common age-related neurodegenerative after Alzheimer's disease. Despite numerous studies, specific factors remain unidentified. This study employed a multi-omics approach to investigate link between PD and aging. We integrated blood gene expression profiles, quantitative trait loci, genome-wide association predictive models, conducted clinical validation.By analyzing datasets, total of 953 differentially expressed genes (DEGs) 10 intersecting aging...
Abstract Background Klebislla pneumoniae is an important bacterium and responsible for both infections acquired in hospital community because of its multidrug resistance the virulence. The aim this research was to investigate clonal lineages, antibiotic profiles virulence factors isolated Carbapenem Resistant strains. Methods Whole-genome sequencing one strain performed using Illumina Hiseq PacBio RS systems. Genomic information comprehensively analyzed by various bioinformatics approaches....