A5101661754- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- MicroRNA in disease regulation
- Sperm and Testicular Function
- Birth, Development, and Health
- Reproductive Biology and Fertility
- Cancer-related molecular mechanisms research
- Gestational Diabetes Research and Management
- Ovarian function and disorders
- Epigenetics and DNA Methylation
- Hearing, Cochlea, Tinnitus, Genetics
- Neonatal Respiratory Health Research
- Immunodeficiency and Autoimmune Disorders
- Pediatric health and respiratory diseases
- Genomics, phytochemicals, and oxidative stress
- Restraint-Related Deaths
- Peptidase Inhibition and Analysis
- Oral and Craniofacial Lesions
- Ear Surgery and Otitis Media
- Amyotrophic Lateral Sclerosis Research
- Circular RNAs in diseases
- Congenital heart defects research
- Autophagy in Disease and Therapy
- Cancer Genomics and Diagnostics
- T-cell and Retrovirus Studies
Inner Mongolia Electric Power Survey & Design Institute (China)
2024
Third Affiliated Hospital of Zhengzhou University
2014-2023
Zhengzhou University
2014-2019
Zhongshan Hospital of Xiamen University
2016
Objective Breast cancer is the most common and high-incidence in women. It mainly treated by surgery combined with chemoradiation. The main challenge treating breast patients developing resistance to chemotherapeutics, so it urgent find potential strategies that can improve chemotherapy effect of patients. In this study, we aimed explore role GSDME methylation sensitivity for cancer. Methods Here, identified MCF-7 / Taxol cells models using quantitative real-time PCR (qRT-PCR), Western...
Purpose: The aim of this study was to investigate the correlations and interactions between polymorphisms insulin resistance-related genes (ADIPOQ rs2241766), inflammation factors (TNF-α rs1800629, IL-6 rs1800795), obesity-related (GNB3 rs5443, ADRB rs1042714), risk for gestational diabetes mellitus (GDM) such as diet structure in development GDM.Materials methods: This research conducted among women who visited third-affiliate hospital Zhengzhou University pregnancy checkups from 1 June...
Background Recent studies reported that serum anion gap could be regarded as a prognostic biomarker for patients admitted to intensive care units. However, the association between AG and mortality in cerebral infarction remained largely unknown.Methods Relevant clinical data were collected from Medical Information Mart Intensive Care III. Patients divided into three groups according tertiles of AG. Kaplan–Meier curve Cox proportional hazards models used evaluate levels all-cause mortality....
Objective: We aimed to investigate Th22 cells and their association with Th17 Treg in the etiology of severe preeclampsia (sPE).Methods: Thirty sPE patients 30 healthy pregnant women were recruited this study. The percentages Th17, Th22, regulatory T (Tregs) peripheral blood measured by flow cytometry. ELISA was used measure plasma concentrations interleukin (IL)-17, IL-22, IL-10.Results: IL-17 IL-22 significantly increased along a decreased percentage IL-10 concentration. There positive...
Although Taxol has improved the survival of cancer patients as a first-line chemotherapeutic agent, an increasing number develop resistance to after prolonged treatment. The potential mechanisms cell are not completely clear. It been reported that microRNAs (miRNAs) involved in regulating sensitivity cells various agents. In this study, we aimed explore role miR-129-5p breast Taxol. Cell apoptosis and autophagy, MCF-7 were assessed with series vitro assays. Our results showed inhibition...
The aim of this study was to investigate the roles oxygen free radicals and mitochondrial signaling in semen disorders, particular, how induces low concentrations reduced motility sperm. Ejaculate samples were obtained from 120 young adult males (mean age, 28.7±5.3 years) with normal (n=30), oligospermia asthenospermia (n=30) oligoasthenozoospermia (n=30). malondialdehyde (MDA) content, total superoxide dismutase (T‑SOD) activity glutathione peroxidase (GSH‑Px) sperm determined by enzymatic...
Preeclampsia (PE) is a pregnancy-specific syndrome that has severe implications on perinatal mortality and morbidity. Excessive apoptosis of trophoblasts induced by hypoxia may be associated with the development PE, but exact pathogenesis unknown. Forkhead box O transcription factor 3a (FOXO3a) activated under hypoxic conditions. Furthermore, hypoxia‑inducible factor‑1α (HIF‑1α) sensitive to variations in partial oxygen pressure. Thus, aims present study were investigate expression levels...
The goal of this study is to evaluate a new (18) F-labeled imaging agent for diagnosing high metastatic (aggressive) hepatocellular carcinoma using positron emission tomography (PET). [(18) F]AlF-NOTA-G-TMTP1 was synthesized and radiolabeled with F NOTA-AlF chelation method. tumor-targeting characteristics assessed in HepG2, SMCC-7721, HCC97L HCCLM3 xenografts. total synthesis time about 20 min radiochemical yield 25 ± 6%. specific activity 11.1-14.8 GBq/µmol at the end based on amount...
Abstract Background The enlarged vestibular aqueduct (EVA) is the commonest malformation of inner ear accompanied by sensorineural hearing loss in children. Three genes SLC26A4 , FOXI1 and KCNJ10 have been associated with EVA, among them being most common. Yet, hotspot mutation screening can only diagnose a small number patients. Methods Thus, this study, we designed new molecular diagnosis panel for EVA based on multiplex PCR enrichment next‐generation sequencing exon flanking regions . A...
Phenylketonuria (PKU, OMIM 261600) caused by phenylalanine hydroxylase (PAH) deficiency is an autosomal recessive disease that characterized abnormalities of metabolism. In this study, a total 77 patients, originating from the central region China and who were diagnosed with PAH at third affiliated hospital Zhengzhou University, enrolled in study. The 13 exons 12 flanking introns gene analyzed Sanger sequencing next generation sequencing. data aligned to hg19, PAHvdb HGMD databases...
Abstract Immunophenotyping of blood lymphocytes has become an important tool in the diagnosis immunologic and hematologic disorders such as immunodeficiencies, lymphoproliferative autoimmune diseases. Lymphocyte subsets include total T‐cells (CD3 + ), TH (T helper, CD3 CD4 TC (cytotoxic T cells, CD8 B‐cells − CD19 NK‐cells CD16 CD56 ). Specific lymphocyte subset reference intervals should be locally established for meaningful comparison to obtain accurate interpretation results. Reference...
Breast cancer (BC) is the most frequently diagnosed tumor in women worldwide. Although combination of surgery and Taxol chemotherapy can achieve a certain therapeutic effect, patients often develop drug-resistance, resulting poor prognosis. Therefore, it significative to seek molecular mechanism resistance. Recent studies have found that abnormal epigenetic regulation breast cells changes expression key genes, which lead occurrence, development, maintenance cancer, even related development...