A5100750029- RNA regulation and disease
- Hearing, Cochlea, Tinnitus, Genetics
- RNA modifications and cancer
- Biopolymer Synthesis and Applications
- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Mitochondrial Function and Pathology
- RNA and protein synthesis mechanisms
- Cellular transport and secretion
- Galectins and Cancer Biology
- Radical Photochemical Reactions
- Cleft Lip and Palate Research
- Retinal Development and Disorders
- Plant-Microbe Interactions and Immunity
- Head and Neck Anomalies
- Insect Utilization and Effects
- Ginseng Biological Effects and Applications
- Insect Resistance and Genetics
- Oxidative Organic Chemistry Reactions
- Plant Pathogenic Bacteria Studies
- Educational Technology and Assessment
- Higher Education and Teaching Methods
- Cholinesterase and Neurodegenerative Diseases
- Congenital Ear and Nasal Anomalies
- Zebrafish Biomedical Research Applications
Beijing Chao-Yang Hospital
2023
Capital Medical University
2023
Zhengzhou University
2012-2021
First Hospital of Jilin University
2017
Hebei Agricultural University
2014-2017
Jilin University
2017
Zhengzhou People's Hospital
2014
Taiyuan Normal University
2010
Harbin Normal University
1993
Host-seeking, ovipositional behavior and mating of insects are controlled mainly by odor perception through sensory organs such as antennae.Antennal chemoreception is extremely important for insect survival.Several antennal chemosensory receptors involved in mediating the detection insects, especially odorant (ORs) ionotropic (IRs), to ensure specificity olfactory neuron responses.In present study, we identified receptor gene repertoire parasitoid wasp Microplitis mediator, a generalist...
Abstract Background Perrault syndrome (PRLTS4; OMIM# 615300) is a rare autosomal recessive disorder and only few cases have been reported worldwide. We report Chinese female characterized by sensorineural hearing loss premature ovarian insufficiency. Methods evaluated audiological, endocrine, ultrasound examinations examined the genetic causes using whole‐exome sequencing. reviewed literature to discuss pathogenesis, genotype–phenotype correlation, treatment, prevention of PRLTS4. Results...
Abstract Background The enlarged vestibular aqueduct (EVA) is the commonest malformation of inner ear accompanied by sensorineural hearing loss in children. Three genes SLC26A4 , FOXI1 and KCNJ10 have been associated with EVA, among them being most common. Yet, hotspot mutation screening can only diagnose a small number patients. Methods Thus, this study, we designed new molecular diagnosis panel for EVA based on multiplex PCR enrichment next‐generation sequencing exon flanking regions . A...
Breast cancer is one of the most serious and deadly cancers in women worldwide, with distant metastases being leading cause death. Tn antigen, a tumor-associated carbohydrate was frequently detected breast cancer, but its exact role metastasis has not been well elucidated. Here we investigated impact antigen expression on underlying mechanisms. The induced two cell lines by deleting T-synthase or Cosmc, both which are required for normal O-glycosylation. It showed that Tn-expressing cells...
Abstract Odorant receptors (ORs) expressed in the antennae of parasitoid wasps are responsible for detection various lipophilic airborne molecules. In present study, 107 novel OR genes were identified from Microplitis mediator antennal transcriptome data. Phylogenetic analysis set M. and demolitor revealed that ( MmedOR ) can be classified into different subfamilies, majority MmedORs each subfamily shared high sequence identities clear orthologous relationships to ORs. Within a subfamily,...
Abstract Background Treacher Collins syndrome‐1 (TCS1; OMIM# 154500) is a rare autosomal dominant disease that defined by congenital craniofacial dysplasia. Here, we report four sporadic and one familial case of TCS1 in Chinese patients with clinical features presenting as hypoplasia the zygomatic complex mandible, downslanting palpebral fissures, coloboma lower eyelids, conductive hearing loss. Materials Methods Audiological, radiological, physical examinations were performed. Targeted...
This study aimed to explore the genetic causes of probands who were diagnosed with Waardenburg syndrome (WS) or congenital sensorineural hearing loss.A detailed physical and audiological examinations carried out make an accurate diagnosis 14 patients from seven unrelated families. We performed whole-exome sequencing in detect potential further validated them by Sanger their family members.The for all WS loss identified. A total heterozygous variants including c.1459C > T, c.123del,...
Abstract Determining the etiology of end-stage renal disease (ESRD) constitutes a great challenge in context transplantation. Evidence is lacking on genetic findings for adult transplant recipients through exome sequencing (ES). Adult patients kidney waitlist were recruited from 2017 to 2019. Trio-ES was conducted families who had multiple affected individuals with nephropathy or clinical suspicion owing early onset extrarenal features. Pathogenic variants confirmed 62 115 post 421 including...
A highly efficient and selective carbon–carbon double bonds cleavage of styrene compounds involving molecular oxygen was achieved using TBHP as a free radical initiator in diethylene glycol diethyl ether medium. Various compounds, such phenyl acrylic acids its esters, 2-substituted 3-phenyl chalcones, 4-phenyl-3-buten-2-one bis(2-phenylvinyl) ketone, 5-benzylidene-1,3-dimethyl-pyrimidine-2,4,6-triones, could be effectively oxidized into the corresponding aryl carbonyl yield up to 99%....
Genetic variants in the WFS1 gene can cause Wolfram syndrome (WS) or autosomal dominant nonsyndromic low-frequency hearing loss (HL). This study is aimed at investigating molecular basis of HL an affected Chinese family and genotype-phenotype correlation variants.The clinical phenotype five-generation was characterized using audiological examinations pedigree analysis. Target exome sequencing 129 known deafness genes bioinformatics analysis were performed among six patients four normal...
To analyze the phenotypic features and pathogenic variants of three unrelated families presenting with nonsyndromic auditory neuropathy spectrum disorder (ANSD).Three recruited that were affected by congenital deafness clinically evaluated, including a detailed family history audiological radiological examination. The peripheral blood all patients their parents was collected for DNA extraction, then, exonic flanking regions enriched sequenced using targeted capture high-throughput sequencing...
Reactions of piperazine hexahydrate with triazol and paraformaldehyde afford a new piperazine-containing ligand: (N,N′-bis(1-H-1,2,4-triazole-1-yl)piperazine) (btp). X-ray crystal diffraction reveals that btp is an overall linear structure. Its Hg2+ polymer displays zigzag chain in which held the chair conformation. In addition, spectra properties 1 are investigated, strong luminescence characteristics found.