A5100444787- Thyroid Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Tryptophan and brain disorders
- Liver Disease Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Drug Transport and Resistance Mechanisms
- Liver Disease and Transplantation
- Virus-based gene therapy research
- MicroRNA in disease regulation
- Stroke Rehabilitation and Recovery
- Head and Neck Anomalies
- Immune cells in cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Circular RNAs in diseases
- Helicobacter pylori-related gastroenterology studies
- Acute Ischemic Stroke Management
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Cancer Mechanisms and Therapy
- Adipose Tissue and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
Fujian Medical University
2019-2025
Union Hospital
2022-2025
Huazhong University of Science and Technology
2021-2025
Hubei Cancer Hospital
2022-2025
First Affiliated Hospital of Henan University
2020-2025
Seoul National University
2025
Chinese Academy of Fishery Sciences
2024
Ministry of Agriculture and Rural Affairs
2019-2024
Chinese People's Liberation Army
2023-2024
Guangdong Pharmaceutical University
2024
Parkinson's disease (PD) is the common age-related neurodegenerative disorder. Sensitive, noninvasive biomarkers that facilitate PD diagnosis and stage assignment are currently unavailable. This study aims to investigate potential of 16 previous reported PD-associated miRNAs as novel for PD. The expression serum was measured by quantitative reverse transcriptase polymerase chain reaction in 138 patients 112 control populations. Analyses were undertaken assess specificity sensitivity predict...
Autism spectrum disorder (ASD) is a complex behavioral diagnosed by social interaction difficulties, restricted verbal communication, and repetitive behaviors. Fecal microbiota transplantation (FMT) safe efficient strategy to adjust gut dysbiosis improve ASD-related symptoms, but its regulatory mechanism unknown. The impact of the functions on ASD development urgently being investigated develop new therapeutic strategies for ASD. We reconstituted valproic acid (VPA)-induced autism mouse...
Abstract Background Macrophage proinflammatory activation contributes to the pathology of severe acute pancreatitis (SAP) and, simultaneously, macrophage functional changes, and increased pyroptosis/necrosis can further exacerbate cellular immune suppression during process SAP, where cyclic GMP–AMP synthase (cGAS)–stimulator interferon genes (STING) plays an important role. However, function mechanism cGAS–STING in SAP-induced lung injury (LI) remains unknown. Methods Lipopolysaccharide...
Abstract mRNA vaccines are regarded as a highly promising avenue for next‐generation cancer therapy. Nevertheless, the intricacy of production, inherent instability, and low expression persistence linear significantly restrict their extensive utilization. Circular RNAs (circRNAs) offer novel solution to these limitations due efficient protein ability, which can be rapidly generated in vitro without need extra modifications. Here, we present neoantigen vaccine based on circRNA that induces...
We explored how blood-brain barrier (BBB) leakage rate of gadolinium chelates (K
BACKGROUND:Berberine, a natural isoquinoline alkaloid derived from Berberis genus plants, has been reported to have anti-cancer effects. While cell behavior can be modulated by long non-coding RNAs (lncRNAs), the contributions of lncRNAs in progression and berberine effects on colorectal cancer are largely unknown. Therefore, present study investigated involvement regulatory function lncRNA susceptibility candidate 2 (CASC2) during treatment human using berberine. MATERIAL AND...
Colorectal cancer (CRC) is one of the most prevalent types malignant tumours. Metastasis leading cause cancer-related mortality, with lung metastases accounting for 32.9% all metastatic CRCs. However, since biological mechanism CRC poorly understood, limited therapeutic targets are available. In present study, we aimed to identify key genes and molecular processes involved in metastasis.The differentially expressed (DEGs) between primary patients were obtained from Gene Expression Omnibus...
This study was conducted to determine the role of neuregulin 1 (NRG1)-dependent human epidermal growth factor receptor 3 (HER3) activation in trastuzumab primary resistance, and observe inhibitory effect HER3 monoclonal antibody on HER2-overexpressing breast cancer cells. BT474 cells (trastuzumab sensitive) MDA-MB-453 resistant) were first stimulated with NRG1 then treated either trastuzumab, antibody, or a combination both. The expression phospho 2 (p-HER2), (p-HER3), protein kinase B...
Abstract Background The central nervous system (CNS) is vulnerable to viral infection, yet few host factors in the CNS are known defend against invasion by neurotropic viruses. Long noncoding RNAs (lncRNAs) have been revealed play critical roles a wide variety of biological processes and highly abundant mammalian brain, but their defending pathogens into remain unclear. Results We report here that multiple viruses, including rabies virus, vesicular stomatitis Semliki Forest herpes simplex...
Abstract The ubiquitous pathogen Toxoplasma gondii has a complex lifestyle with different metabolic activities at stages that are intimately linked to the parasitic environments. Here we identified eukaryotic regulator of cellular homeostasis AMP-activated protein kinase (AMPK) in and discovered its role programming during parasite’s lytic cycle. catalytic subunit AMPKα is quickly phosphorylated after release intracellular parasites extracellular environments, driving energy-producing...
Polycystic ovary syndrome is a metabolic and hormonal disorder that closely linked to oxidative stress. Within individuals diagnosed with PCOS, changes occur in the ovaries, resulting an excessive buildup of iron peroxidation lipids, both which may be associated occurrence ferroptosis. Baicalein, flavonoid found roots Scutellaria baicalensis widely known as Chinese skullcap, for its anti-inflammatory anti-ferroptotic properties, protect against various diseases. Nevertheless, there has been...
Summary Chimeric antigen receptor T‐cell (CAR‐T) therapy has shown transformative potential in treating malignant tumours, with increasing global approval of CAR‐T products. However, high‐production costs and risks associated viral vector‐based cells—such as insertional mutagenesis secondary tumour formation—remain challenges. Our study introduces an innovative engineering approach using mRNA delivered via lipid nanoparticles (LNPs), aiming to reduce enhance safety while maintaining strong...
Some patients with non-small-cell lung cancer (NSCLC) benefit from immune checkpoint inhibitors (ICIs) despite programmed death-ligand 1 (PD-L1) expression. To address the mechanism of ICI resistance in PD-L1-positive NSCLC, we investigated role tumor-cell-intrinsic function PD-L1 interleukin (IL)-6-mediated immunosuppression. Cohorts NSCLC treated and public datasets were analyzed. PD-L1-overexpressing PD-L1-knockdown cells submitted to RNA-seq, vitro analyses, chromatin...