A5053887136- CAR-T cell therapy research
- Pancreatic function and diabetes
- Xenotransplantation and immune response
- Circadian rhythm and melatonin
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Blood transfusion and management
- Endoplasmic Reticulum Stress and Disease
- Sleep and related disorders
- Platelet Disorders and Treatments
- Orthopedic Surgery and Rehabilitation
- Viral Infectious Diseases and Gene Expression in Insects
- Virus-based gene therapy research
- Sarcoidosis and Beryllium Toxicity Research
- Cholesterol and Lipid Metabolism
- Digital Platforms and Economics
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- T-cell and B-cell Immunology
- Blood groups and transfusion
- Medical and Biological Ozone Research
- Cancer-related molecular mechanisms research
- Diet, Metabolism, and Disease
- Head and Neck Cancer Studies
- Bone Tumor Diagnosis and Treatments
- Ear and Head Tumors
Huazhong University of Science and Technology
2007-2025
Union Hospital
2025
Hubei Cancer Hospital
2025
National Sun Yat-sen University
2024
Dalian Medical University
2024
First Affiliated Hospital of Dalian Medical University
2024
Peking Union Medical College Hospital
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Jilin University
2021
First Hospital of Jilin University
2021
Summary Chimeric antigen receptor T‐cell (CAR‐T) therapy has shown transformative potential in treating malignant tumours, with increasing global approval of CAR‐T products. However, high‐production costs and risks associated viral vector‐based cells—such as insertional mutagenesis secondary tumour formation—remain challenges. Our study introduces an innovative engineering approach using mRNA delivered via lipid nanoparticles (LNPs), aiming to reduce enhance safety while maintaining strong...
The reduction in insulin secretory capacity and beta-cell mass has been attributed, at least partially, to lipotoxicity, which may contribute the development of type 2 diabetes. Chronic free fatty acids (FFA) exposure impairs pancreatic function induces apoptosis. This study is elucidate underlying molecular mechanisms.We exposed INS-1E line palmitate or oleate, measured glucose stimulated secretion (GSIS). effect FFA on sterol regulatory element-binding protein (SREBP)-1c lipogenic pathway,...
The rapid development of quantitative portfolio optimization in financial engineering has produced promising results AI-based algorithmic trading strategies. However, the complexity markets poses challenges for comprehensive simulation due to various factors, such as abrupt transitions, unpredictable hidden causal and heavy tail properties. This paper aims address these by employing heavy-tailed preserving normalizing flows simulate high-dimensional joint probability complex environment...
Summary Type 1 diabetes (T1D) is due to a loss of immune tolerance islet antigens, such as glutamic acid decarboxylase 65 (GAD65), for which transplantation promising therapy. Therefore, the generation aiming at both alloantigen and GAD65 will help therapeutic intervention greatly in T1D. In this study, we tested effect programmed death-1 ligands (PD-L1)-transfected dendritic cells (DC) loaded with on alloresponse GAD65-reactive lymphocyte response. The DC2·4 cell line was transfected PD-L1...
Temporomandibular joint (TMJ) diseases are common clinical conditions. The number of patients with TMJ is large, and the etiology, epidemiology, disease spectrum, treatment remain controversial unknown. To understand master current situation occurrence, development prevention diseases, as well to identify patterns in incidence, drug sensitivity, prognosis crucial for alleviating patients'suffering.This will facilitate in-depth medical research, effective measures, formulation corresponding...
To explore whether T lymphocytes subgroup, B lymphocytes, platelet antigen CD41a, CD61 or antibodies are involved in the transfusion refractoriness.Forty-seven patients diagnosed as refractoriness and 32 that achieved effective therapy were ennolled this study. Flow cytometry was performed to detect proportion of cytotoxic cell (CD3(+)CD4(-)CD8(+)), helper (CD3(+)CD4(+)CD8(-)) (CD19 (+) ), expression glycoproteins, including CD41a CD61, while also measured by solid-phase agglutination.The...
Fazit Das vorgestellte Verfahren könnte den üblichen zweizeitigen Eingriff der Frakturstabilisierung und nachfolgender Entfernung des Tumorgewebes mit Defektauffüllung ersetzen. Allerdings liegen dieser Publikation nur die Daten von 8 Studienteilnehmern zugrunde. Die Studie sagt auch nichts über Einsatz Methode bei dislozierten Frakturen aus. Hier sollten erst weitere Studien validen erfolgen, um genauere Aussagen machen zu können.
Objective: To describe the clinical characteristics of sarcoidosis patients with arrhythmia as primary or main manifestation. Methods: We conducted a retrospective analysis arrhythmia-onset cases between January 2017 and December 2020. Their manifestations, radiological features, treatment prognosis were reviewed analyzed. Results: This study consisted 3 females 1 male, mean age 51 years (range from 42 to 58 old). Arrhythmia was first manifestation for all 4 cases, involving Ⅲ°...