A5101856670- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Liver Disease and Transplantation
- Endoplasmic Reticulum Stress and Disease
- COVID-19 Clinical Research Studies
- Hepatitis B Virus Studies
- Autophagy in Disease and Therapy
- Lipid metabolism and disorders
- Mosquito-borne diseases and control
- Long-Term Effects of COVID-19
- Alcohol Consumption and Health Effects
- Liver Diseases and Immunity
- Drug-Induced Hepatotoxicity and Protection
- Diabetes and associated disorders
- Lipid metabolism and biosynthesis
- Liver physiology and pathology
- Peroxisome Proliferator-Activated Receptors
- Cancer-related molecular mechanisms research
- Inflammatory mediators and NSAID effects
- Pneumothorax, Barotrauma, Emphysema
- Polyomavirus and related diseases
- Fibroblast Growth Factor Research
- Cancer, Lipids, and Metabolism
- Sarcoidosis and Beryllium Toxicity Research
- Genetic Syndromes and Imprinting
Huazhong University of Science and Technology
2010-2023
Union Hospital
2010-2023
Peking Union Medical College Hospital
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Tongji Hospital
2020
Wuhan Union Hospital
2013-2020
Union Hospital
2016-2020
Scoparone has been shown to ameliorate many forms of liver disease, and several underlying molecular mechanisms involved have previously revealed. However, the potential role scoparone in autophagy, which is dysregulated nonalcoholic fatty disease-nonalcoholic steatohepatitis (NAFLD-NASH), not evaluated. In current study, we investigated effect hepatic autophagy mice with NASH. vivo, were fed a methionine–choline deficient (MCD) diet establish NASH model then subjected treatment or without...
Background: Hepatocellular carcinoma (HCC) is the world’s second most deadly cancer, and metabolic reprogramming its distinguishing feature. Among metabolite profiling, variation in amino acid metabolism supports tumor proliferation metastasis to extent, yet a systematic study on role of metabolism-related genes HCC still lacking. An effective prediction signature urgently needed assess prognosis patients for individualized treatment. Materials Methods: RNA-seq data from TCGA-LIHC GSE14520...
The epidemic of the 2019 Novel Coronavirus (2019-nCoV) infection has presented as a grim and complex situation recently. More than 11,000 cases 2019-nCoV been confirmed in China until February 1
Cyclic adenosine monophosphate (AMP)-responsive element-binding protein H (CREBH), an endoplasmic reticulum-anchored transcription factor essential for lipid metabolism and inflammation in nonalcoholic fatty liver disease (NAFLD), is covalently modified by N-acetylglucosamine. Glycosylation a ubiquitous type of involved posttranslational modifications, plays critical role various biological processes. However, the mechanism glycosylated CREBH remains poorly understood NAFLD.CREBH...
We have demonstrated runt-related transcription factor 2 (Runx2) plays important role in atherosclerosis. It has been indicated that atherosclerosis shares the similar histopathology with nonalcoholic steatohepatitis (NASH), a progressive stage of fatty liver disease (NAFLD), on macrophages infiltration. However, function Runx2 NAFLD is completely unknown. Here, we investigated underlying mechanism triggering infiltration development NAFLD.Mice were fed high-fat diet (HFD) for long time....
Sterol regulatory element binding protein‑2 (SREBP‑2) is an important transcription factor in lipid homeostasis. A previous study showed that SREBP‑2 also activated autophagic genes during cell‑sterol depletion. Alterations autophagy are reported to be involved the pathogenesis of nonalcoholic fatty liver disease (NAFLD). However, whether regulation restores dysfunctional hepatocytes NAFLD remains elucidated. In present study, a steatosis model was established with palmitic acid (PA)...
Bone morphogenetic protein (BMP)-9, a member of the TGFβ-family cytokines, is believed to be mainly produced in liver. The serum levels BMP-9 were reported reduced newly diagnosed diabetic patients and overexpression ameliorated steatosis high fat diet-induced obesity mouse model. Furthermore, injection mice enhanced expression fibroblast growth factor (FGF)21. However, whether also regulates related FGF19 not clear. Because both FGF21 19 described protect liver from steatosis, we have...
Liver inflammation and macrophage infiltration are critical steps in the progression of non‑alcoholic fatty liver to development steatohepatitis. Bone morphogenetic protein‑9 is a cytokine involved regulation chemokines lipogenesis. However, function bone steatohepatitis still unknown. The present study hypothesized that may contribute mice fed methionine choline deficiency diet (MCD). C57BL/6 overexpressing control were MCD for 4 weeks. tissue serum samples obtained subsequent measurements....
This study aimed to analyze the diagnostic accuracy of liver stiffness for predicting esophageal variceal grading and risk bleeding (EVB) in cases cirrhosis. Hematological biochemical parameters were measured transient elastography was performed 88 patients with hepatitis B-related cirrhosis undergoing endoscopy varices. Esophageal varices grade highly correlated measurement (LSM) spleen diameter-to-platelet score Compared those from endoscopy, LSM absence as follows: area under receiver...