A5101410996- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Streptococcal Infections and Treatments
- Liver Diseases and Immunity
- Liver Disease and Transplantation
- Gastrointestinal Tumor Research and Treatment
- Autophagy in Disease and Therapy
- Immune cells in cancer
- Immune Cell Function and Interaction
- Infectious Diseases and Mycology
- Lymphoma Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Gastric Cancer Management and Outcomes
- Cardiac Ischemia and Reperfusion
- Neonatal and fetal brain pathology
- Actinomycetales infections and treatment
- Lipid metabolism and disorders
- Colorectal and Anal Carcinomas
- Nosocomial Infections in ICU
- Head and Neck Anomalies
Zhengzhou University
2020-2024
Jiangsu Food and Pharmaceutical Science College
2024
Affiliated Hospital of Taishan Medical University
2023
Shandong First Medical University
2023
Zhejiang University
2008-2022
Sir Run Run Shaw Hospital
2014-2022
Genesee Community College
2021
Union Hospital
2019-2020
Huazhong University of Science and Technology
2019-2020
Henan Cancer Hospital
2020
Scoparone has been shown to ameliorate many forms of liver disease, and several underlying molecular mechanisms involved have previously revealed. However, the potential role scoparone in autophagy, which is dysregulated nonalcoholic fatty disease-nonalcoholic steatohepatitis (NAFLD-NASH), not evaluated. In current study, we investigated effect hepatic autophagy mice with NASH. vivo, were fed a methionine–choline deficient (MCD) diet establish NASH model then subjected treatment or without...
Background The Camrelizumab Plus Apatinib in Patients with Advanced Cervical Cancer trial was a single-arm, phase II study that showed promising activity of the programmed death-1 (PD-1) inhibitor camrelizumab plus vascular endothelial growth factor receptor-2 apatinib patients advanced cervical cancer. However, predictive biomarkers for treatment outcomes are unknown. In this study, we aimed to identify potential predictors response PD-1 combination therapy. Methods Genomic profiling...
Hepatitis E virus (HEV) infection is the most common cause of acute viral hepatitis worldwide and one main causes death in last decade, causing chronic liver failure some populations. The aging population obesity are two major factors threatening human health. Therefore, we want to understand relationship between these groups HEV infection.The study aimed analyze epidemiological, clinical, laboratory features evaluate probable high-risk for disease progression current diagnostic strategies...
Background: Lung mechanics during invasive mechanical ventilation (IMV) for both prognostic and therapeutic implications; however, the full trajectory lung has never been described novel coronavirus disease 2019 (COVID-19) patients requiring IMV. The study aimed to describe of mechanically ventilated COVID-19 patients. clinical ventilator setting that can influence patient-ventilator asynchrony (PVA) compliance were explored. Post-extubation spirometry test was performed assess pulmonary...
Junli Zhang, Changzheng Li, Pengfei Ma, Yanghui Cao, Janusz Włodarczyk, Mohsen Ibrahim, Chenyu Liu, Sen Xijie Guangsen Han, Yuzhou Zhao
Secondary infection, especially bloodstream is an important cause of death in critically ill patients with COVID-19. We aimed to describe secondary infection (SBI) adults COVID-19 the intensive care unit (ICU) and explore risk factors related SBI.We reviewed all SBI cases among from 12 February 2020 24 March ICU Jingmen First People's Hospital. compared associated this study. All SBIs were confirmed by blood culture.We identified five 32 patients: three Enterococcus faecium, one mixed...
Objective Liver biopsy is the gold standard test for assessment of liver pathology. This study was performed to assess predictive value spleen thickness pathology and role routine follow-up procedures in significant patients with chronic hepatitis B (CHB) persistently normal alanine aminotransferase (PNALT) or minimally raised (ALT). Methods Patients CHB who underwent percutaneous were retrospectively reviewed. The relationship age, ALT, e-antigen, statistically analyzed, accuracy evaluated....
The timing of invasive mechanical ventilation (IMV) is controversial in COVID-19 patients with acute respiratory hypoxemia. study aimed to develop a novel predictor called cumulative oxygen deficit (COD) for the risk stratification.The was conducted four designated hospitals treating Jingmen, Wuhan, from January March 2020. COD defined account both magnitude and duration A higher value indicated more deficit. predictive performance calculated multivariable Cox regression models.A number 111...
Changzheng Li, Zhenyu Jiachen Zhang, Xijie Matthew Yuan-Kun Wei, Nan Zun Teo, Pengfei Ma, Junli Sen Zhi Yuzhou Zhao
Rhodococcus equi (R. equi) is an uncommon gram positive organism. It a rare but recognized pathogen in humans and has emerged as important cause of morbidity mortality among immunocompromised patients. Generally, R. infection needs combined treatment with effective antibiotics, often requires the immune adjuvant therapy. Here we reported 49-year-old man presented dyspnea fever, skin ulcer for 5 months, final diagnosis was diffuse large B cell lymphoma septicemia pneumonia, failure, blood...
Cryptococcus spp. is a complex species that often causes cryptococcosis, which one of the most common opportunistic infections in adults living with HIV and has very high morbidity mortality rates. This study aimed to investigate antifungal susceptibility profiles epidemiological characteristics neoformans (CNSC) gattii (CGSC) Zhejiang Province, China. A total 177 CNSC 3 CGSC isolates were collected, was tested by FUNGUS verified an E-test. Moreover, multiple classification methods genomic...
Streptococcus pyogenes (GAS) may cause severe invasive disease with a high fatality rate, especially M3-type strains, which are less common in China. Here, we report the first emm3/ST15 GAS infection case The patient was diagnosed skin and soft tissue (SSTI) septicaemia caused by one strain. Antibiotic susceptibility tests showed that isolate susceptible to all tested drugs. Antimicrobial therapy then applied, fully recovered discharged from hospital on Day 43. Whole-genome sequencing...
Objective To investigate the resistance of carbapenems,the production metallobeta-lactamases(MBLs)and homology analysis Psendomonas aeruginosa in China.Methods A total 654 Pseudomonas isolates were collected from 28 hospitals 16 difierent regions during period July 2006 to 2007 as part Nosocomial Pathogen Resistance Surveillance(NPRS).MICs imipenem and meropenem determined by agar dilutiom PFGE was used analyze molecular epidemiology carbapenem-resistant strains.MBLs detected Etest PCR among...
Recently,because the wide use of immune inhabitor and antibiotics,the incidence invasivepulmonary aspergillosis(IPA)become much higher than before.IPA has high mortality rate,early diagnosis therapyCan improve patient survival rates.Traditional methods such as culture low sensitivity,pathology histology ex-amine some damage,therefore nonculture methods,like PCR,ELISA CT ale now used to guide evaluate thecurative effect.In review,we summarize ways early for IPA. Key words:...
Eperythrozoonosis is a zoonosis transmitted from animals to humans. It caused by bacteria in the genus Eperythrozoon. These have high infection rate and can cause varying degrees of damage. This first case report infective endocarditis The patient had 30-day history remittent fever accompanied chills progressive weakness gradually recovered after 6 weeks minocycline treatment.
Objective To evaluate the performance of an enhanced fluorescent staining for rapid diagnosis invasive mycosis, especially rare cases, considering traditional culture method always leads to delays in clinical its time consuming. Methods Cases mycosis identified by our hospital from September, 2017 2018 were retrospectively analyzed. Three infections reported this study. Clinical specimens pretreated using standard procedures and then smeared on slides along with dye. Species pathogens...