A5038761572- Tracheal and airway disorders
- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Airway Management and Intubation Techniques
- Voice and Speech Disorders
- Congenital Diaphragmatic Hernia Studies
- Respiratory Support and Mechanisms
- Lung Cancer Research Studies
- Transplantation: Methods and Outcomes
- Vascular Anomalies and Treatments
- Neuroendocrine Tumor Research Advances
- Trauma Management and Diagnosis
- Lung Cancer Treatments and Mutations
- Myasthenia Gravis and Thymoma
- Immune Response and Inflammation
- Gastric Cancer Management and Outcomes
- Cancer Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Tissue Engineering and Regenerative Medicine
- Anesthesia and Pain Management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mesenchymal stem cell research
- Esophageal Cancer Research and Treatment
- Head and Neck Surgical Oncology
- Salivary Gland Tumors Diagnosis and Treatment
Azienda Ospedaliera Sant'Andrea
2007-2025
Sapienza University of Rome
2015-2024
Port Said University
2022-2024
Lady Reading Hospital
2024
Cairo University
2023
Thoracic Surgery Foundation
2021
Washington University in St. Louis
2012-2020
Al-Azhar University
2020
China-Japan Friendship Hospital
2018
Policlinico Umberto I
2007-2018
Background. Mitochondrial DNA (MT-DNA) are intrinsically inflammatory nucleic acids released by damaged solid organs. Whether circulating cell-free MT-DNA quantitation could be used to predict the risk of poor COVID-19 outcomes remains undetermined.
SUMMARY Mitochondrial DNA (MT-DNA) are intrinsically inflammatory nucleic acids released by damaged solid organs. Whether the appearance of cell-free MT-DNA is linked to poor COVID-19 outcomes remains undetermined. Here, we quantified circulating in prospectively collected, plasma samples from 97 subjects with at time hospital presentation. Circulating were sharply elevated patients who eventually died, required ICU admission or intubation. Multivariate regression analysis revealed that high...
Long-term results of patients undergoing laryngotracheal resection for benign stenosis are reported. This is the largest series ever published.Between 1991 and March 2015, 109 consecutive (64 males, 45 females; mean age 39 ± 10.9 years) underwent subglottic postintubation (93) or idiopathic (16) stenosis. Preoperative procedures included tracheostomy in 35 patients, laser 17 plus stenting 18. The upper limit ranged between actual involvement vocal cords 1.5 cm from glottis. Airway length 6...
A prospective, randomized study to evaluate the effectiveness and safety of a polymeric sealant (Coseal, Baxter Healthcare, Deerfield, IL) reduce air leaks improve postoperative outcome in patients undergoing lung resection.Between November 2005 February 2008, 203 (128 M, 75 F) showing moderate/severe intraoperative after pulmonary lobectomy/bilobectomy/sleeve lobectomy (110) or minor resection (segmentectomy/wedge) (93) have been prospectively enrolled randomly assigned receive one two...
Abstract The mechanisms that link bacterial infection to solid organ rejection remain unclear. In this study, we show following the establishment of lung allograft acceptance in mice, Pseudomonas aeruginosa airway induces a G-CSF–dependent neutrophilia stimulates acute rejection. Graft-infiltrating neutrophils sharply upregulate B7 molecules CD80 and CD86, but they do not express CD40 or MHC class II response P. infection. Neutrophil promotes naive CD4+ T cell activation intragraft IL-2+,...
The management of postoperative pain in thoracic surgery is an open issue. aim this study was to compare after a videothoracoscopic lobectomy versus mini-thoracotomy approach. Between April 2011 and January 2013 we enrolled prospective, non-randomized 145 patients undergoing pulmonary with lymphadenectomy for Stage I lung cancer. In 75 cases (Group A), performed through 70 B), undertaken conservative mini-thoracotomy. Pain assessed by visual analogue scale function spirometry six-minute...
Neutrophil extracellular traps (NETs) have been shown to worsen acute pulmonary injury including after lung transplantation. The breakdown of NETs by DNAse-1 can help restore function, but whether there is an impact on allograft tolerance remains less clear. Using intravital 2-photon microscopy, we analyzed the effects in mouse orthotopic allografts damaged ischemia-reperfusion injury. Although treatment rapidly degrades intragraft NETs, consequential release NET fragments induces prolonged...
OBJECTIVE. The optimal surgical approach for thymoma resection is still an object of debate. increasing experience in robotic-assisted thoracic surgery (RATS) has led to the progressive affirmation this technique as a valid alternative Sternotomy, Thoracotomy and Video-Assisted Thoracic Surgery (VATS) setting. present study aims compare post-operative short-term results RATS Thymectomy with those other main approaches (sternotomy, thoracotomy VATS) from high-volume single center. METHODS....
Surgery is the first line of treatment for laryngotracheal stenosis; Montgomery tube or permanent tracheostomy have been so far only alternatives. Nd-YAG laser resection and indwelling endotracheal stents rarely used in subglottic stenosis anatomic technical reasons. We latter approach to optimize timing surgery achieve palliation without tracheostomy.Between 1991 2001 we treated 18 patients with (10 males, 8 females; age range 14-78, mean 34). The upper margin stricture was 2mm 1cm below...
The aim of the study was to assess feasibility, efficacy and safety use a conical self-expandable stent for treatment post-pneumonectomy bronchopleural fistula (PPBPF). Between April 2008 November 2010, six patients underwent PPBPF by introduction tracheobronchial fully covered nitinol with excluding bronchial dehiscence from airflow. We secured prosthesis tracheal mucosa titanium helical fasteners tacks. Five presented larger than 5 mm following right (4) or left (1) pneumonectomy. One...
We retrospectively analysed morbidity, mortality and oncological results of patients who had undergone surgery for bronchial carcinoid tumours.Between 2002 2012, 65 with carcinoids underwent lobectomy (n = 34), sublobar resection (segmentectomy/wedge) 18), sleeve 5) (reconstruction the pulmonary artery was associated in 1 case), main bronchus 4) or pneumonectomy carina case).Resection radical histologically negative margins all (R0). Histology showed typical (TC) 55 (84.6%) atypical (AC) 10...
To evaluate the efficacy of Endo-Bronchial Valves in management persistent air-leaks (PALs) and procedural cost.It was a retrospective multicenter study including consecutive patients with PALs for alveolar pleural fistula (APF) undergoing valve treatment. We assessed cost procedure.Seventy-four air leaks due to various etiologies were included analysis. In all cases severe refractory standard treatments. Sixty-seven (91%) underwent treatment obtaining complete resolution 59 (88%) patients;...
Background: Despite bronchoscopic lung volume reduction (BLVR) with valves is a minimally invasive treatment for emphysema, it can associate some complications. We aimed at evaluating the rate and type of complications related to valve their impact on clinical outcomes. Methods: It retrospective multicenter study including all consecutive patients severe heterogeneous emphysema undergoing BLVR endobronchial developed any this procedure. The complication, time onset, required out-come were...