A5033149046- Immune Cell Function and Interaction
- interferon and immune responses
- Immune Response and Inflammation
- Cancer, Hypoxia, and Metabolism
- T-cell and B-cell Immunology
- Genomics, phytochemicals, and oxidative stress
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Transplantation: Methods and Outcomes
- Immunodeficiency and Autoimmune Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Immunotherapy and Biomarkers
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Bladder and Urothelial Cancer Treatments
- Viral gastroenteritis research and epidemiology
- Cytomegalovirus and herpesvirus research
- CAR-T cell therapy research
- Redox biology and oxidative stress
- Virus-based gene therapy research
- Psoriasis: Treatment and Pathogenesis
- Cytokine Signaling Pathways and Interactions
- Epigenetics and DNA Methylation
- Dermatology and Skin Diseases
- Cancer Genomics and Diagnostics
Washington University in St. Louis
2013-2024
Center for Rheumatology
2022
Medical College of Wisconsin
2012
Howard Hughes Medical Institute
2012
University of Pennsylvania
2012
University of California, San Diego
2012
Semmelweis University
2008
Memory T lymphocytes are commonly viewed as a major barrier for long-term survival of organ allografts and thought to accelerate rejection responses due their rapid infiltration into allografts, low threshold activation, ability produce inflammatory mediators. Because memory cells usually associated with rejection, preclinical protocols have been developed target this population in transplant recipients. Here, using murine model, we found that costimulatory blockade–mediated lung allograft...
Germline gain-of-function (GOF) variants in STAT3 cause an inborn error of immunity associated with early-onset poly-autoimmunity and immune dysregulation. To study tissue-specific dysregulation, we used a mouse model carrying missense variant (p.G421R) that causes human disease. We observed spontaneous imiquimod (IMQ)-induced skin inflammation cell-intrinsic local Th17 responses GOF mice. CD4+ T cells were sufficient to drive showed increased Il22 expression expanded clones. Certain aspects...
Abstract There is an unmet need for new therapies to promote mucosal healing and restoration of epithelial barrier function in inflammatory bowel disease (IBD). Major therapeutics IBD act systemically; however, the development novel approaches specifically deliver a therapy gut has theoretical advantage optimizing benefit while limiting side effects. Adenoviral (Ad) gene been successful treating cancer recently used clinical trials as vaccine SARS-Cov2. Ad vectors can be modified target...
Primary immune regulatory disorders (PIRD) represent a group of characterized by dysregulation, presenting with wide range clinical disease, including autoimmunity, autoinflammation, or lymphoproliferation. Autosomal dominant germline gain-of-function (GOF) variants in STAT3 result PIRD broad spectrum. Studies patients have documented decreased frequency FOXP3+ Tregs and an increased Th17 cells some active disease. However, the mechanisms disease pathogenesis GOF syndrome remain largely...
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide and results from a complex interaction between carcinogen exposure inherent susceptibility. Despite its prevalence, genetic factors that predispose to development remain elusive. Inbred mouse models offer unique clinically relevant tool study contribute carcinogenesis due tumors resemble human adenocarcinoma broad strain-specific variation in incidence after administration. Here, we set out investigate...
Abstract TLR agonists are effective at treating superficial cancerous lesions, but their use internally for other types of tumors remains challenging because toxicity. In this article, we report that murine and human naive CD4+ T cells sequester Pam3Cys4 (CD4+ TPam3) become primed Th1 differentiation. TPam3 encoding the OVA-specific TCR OT2, when transferred into mice bearing established TGF-β–OVA–expressing thymomas, produce high amounts IFN-γ sensitize to PD-1/programmed cell death ligand...
Unlike other tumors, lung cancer appears to be poorly sensitive immunotherapy. We have recently demonstrated an alternative pathway of immunosurveillance. Our data indicate a failure the adaptive immune system mediate immunosurveillance and emphasize prominent role natural killer cells in this setting.
<p>PDF file - 30K, Cytotoxicity of NK cells from C57BL/10 and Balb/c mice</p>
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<p>PDF file - 25K, Cytotoxicity of neutrophils and monocytes/macrophages</p>
<p>PDF file - 47K, SNP rs13459098 in the Pas-1 locus is of 129 origin 129/SvEv.B6-NKC Rag2-/- mice</p>
<p>PDF file - 36K, T cell depletion in AJ mice</p>
<p>PDF file - 76K, Microsatellite mapping of the 129/SvEv.B6-NKC Rag2-/- mouse</p>
<p>PDF file - 21K, Strain-specific differences in Yac-1 cytotoxcity</p>
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<p>PDF file - 25K, Cytotoxicity of neutrophils and monocytes/macrophages</p>
<p>PDF file - 21K, Strain-specific differences in Yac-1 cytotoxcity</p>
<p>PDF file - 47K, SNP rs13459098 in the Pas-1 locus is of 129 origin 129/SvEv.B6-NKC Rag2-/- mice</p>
<p>PDF file - 76K, Microsatellite mapping of the 129/SvEv.B6-NKC Rag2-/- mouse</p>