A5014708652- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Liver Disease Diagnosis and Treatment
- Genetic and phenotypic traits in livestock
- Cancer-related molecular mechanisms research
- Diet, Metabolism, and Disease
- DNA and Nucleic Acid Chemistry
- RNA Interference and Gene Delivery
- Electrochemical sensors and biosensors
- Genetic Mapping and Diversity in Plants and Animals
- Advanced Biosensing Techniques and Applications
- Electrochemical Analysis and Applications
- SARS-CoV-2 detection and testing
- Molecular Junctions and Nanostructures
- Liver physiology and pathology
- Endoplasmic Reticulum Stress and Disease
- Carbon and Quantum Dots Applications
- Nanocluster Synthesis and Applications
- Liver Diseases and Immunity
- Liver Disease and Transplantation
- Molecular Biology Techniques and Applications
- Autophagy in Disease and Therapy
- Animal Genetics and Reproduction
- Graphene and Nanomaterials Applications
- Circular RNAs in diseases
Xinjiang Normal University
2015-2024
Southwest Medical University
2024
Union Hospital
2017-2023
Huazhong University of Science and Technology
2017-2023
South China Agricultural University
2020-2022
Urumqi Vocational University
2020
National Natural Science Foundation of China
2019
Creative Commons
2019
Collaborative Innovation Center of Chemistry for Energy Materials
2015
University of Science and Technology of China
2015
Scoparone has been shown to ameliorate many forms of liver disease, and several underlying molecular mechanisms involved have previously revealed. However, the potential role scoparone in autophagy, which is dysregulated nonalcoholic fatty disease-nonalcoholic steatohepatitis (NAFLD-NASH), not evaluated. In current study, we investigated effect hepatic autophagy mice with NASH. vivo, were fed a methionine–choline deficient (MCD) diet establish NASH model then subjected treatment or without...
The electrochemiluminescence (ECL) behavior of N-(aminobutyl)-N-(ethylisoluminol)/hemin dual-functionalized graphene hybrids (A-H-GNs) and luminol-functionalized silver/graphene oxide composite (luminol-AgNPs-GO) was investigated under cyclic voltammetry pulse potential. It found that A-H-GNs luminol-AgNPs-GO exhibited excellent ECL activity. On this basis, a label-free aptasensor for 2,4,6-trinitrotoluene (TNT) detection developed based on bilayer structure luminescence functionalized...
Discovering efficient antibacterial materials is crucial in the area of increasing drug resistance. Herein, we synthesized carbon dots (C-dots) with superior activity through a simple one-step hydrothermal method. In this method, p-phenylenediamine serves as not only source but also origin for functional group anchored on obtained C-dots. The C-dots was tested against Staphylococcus aureus and Escherichia coli. minimum bactericidal concentrations S. E. coli were 2 30 μg/mL, respectively,...
Carbon quantum dots (CQDs), as a new carbonaceous nanomaterial, have attracted considerable attention due to their excellent properties. In this work, eggshell membrane (ESM), an carbon source that is very easy obtain, was used synthesize water-soluble and fluorescent CQDs with rapid, environmentally friendly waste-recycling hydrothermal method. The synthesized functionalized showed superior water dispersibility stability maximum fluorescence emission peak at 420 nm. yield approximately 9.6%...
Runs of homozygosity (ROH) and heterozygosity (ROHet) are windows into population demographic history adaptive evolution. Numerous studies have shown that deleterious mutations enriched in the ROH humans, pigs, cattle, chickens. However, relationship variants to pattern ROHet goats been largely understudied. Here, 240 Guangfeng Ganxi from Jiangxi Province, China, were genotyped using Illumina GoatSNP50 BeadChip genome-wide ROH, ROHet, genetic load analyses performed context 32 global goat...
Abstract Laiwu pigs are a Chinese indigenous breed that is renowned for its exceptionally high intramuscular fat content (average greater than 6%), providing an excellent genetic resource the improvement of meat quality modern commercial pigs. To uncover diversity, population structure, signature selection, and potential exotic introgression in this breed, we sampled 238 from state‐supported conservation genotyped these individuals using GeneSeek 80K SNP BeadChip. We then conducted in‐depth...
Runs of homozygosity (ROH) are widely used to investigate genetic diversity, demographic history, and positive selection signatures livestock. Commercial breeds provide excellent materials reveal the landscape ROH shaped during intense process. Here, we GeneSeek Porcine 50K single-nucleotide polymorphism (SNP) Chip data 3,770 American Duroc (AD) 2,096 Canadian (CD) pigs analyze genome-wide ROH. First, showed that AD had a moderate differentiation with CD pigs, more abundant diversity...
Binding-induced quenching of AMT to G-quadruplex is used for the first time design an improved fluorescent Pb<sup>2+</sup> aptasensor.
Non‑alcoholic steatohepatitis (NASH) is a common clinicopathological condition. Currently, the pathogenesis of NASH remains unknown, and no optimal therapy option currently exists. It has previously been demonstrated that diallyl disulfide (DADS) was capable attenuating liver dysfunction, as DADS supplementation had positive impact on regeneration, proliferation oxidative damage. Thus, could serve potential therapeutic agent can protect against effects NASH. The present study aimed to...
Abstract Poly(aniline‐luminol‐hemin) nanocomposites are prepared on an electrode surface through electropolymerization, and a highly sensitive electrochemiluminescence (ECL) biosensor for choline is developed based the poly(aniline‐luminol‐hemin) enzyme catalyzed reaction of oxidase (CHOD). The obtained characterized by scanning electron microscopy (SEM), atomic absorption spectrometry (AAS) ECL. results indicate that hemin can be incorporated into poly(aniline‐luminol) using facile...
Abstract A novel electrochemiluminescence biosensor was presented for the assay of hepatitis B virus (HBV) DNA. Coralloid poly(aniline‐luminol)‐MWCNTs prepared on an electrode surface, which followed by attachment capture DNA via amide bond formation. The HBV‐DNA and ferrocene labelled hybridized with to form a sandwich structure surface. Ferrocene can effectively increase signal output ECL sensor due catalysis luminol. rendered linear dependence over range from 1.0×10 −16 −7 M low detection...
Runs of homozygosity (ROH) are widely used to estimate genomic inbreeding, which is linked inbreeding depression on phenotypes. However, the adverse effects specific homozygous regions phenotypic characteristics rarely studied in livestock. In this study, 50 K SNP data 3,770 S21 Duroc (American origin) and 2,096 S22 (Canadian pigs were investigate harmful ROH five economic traits. The results showed that two lines had different numbers distributions unfavorable ROHs, may be related selection...
Chinese goats are an important group of worldwide. However, there few studies on the conservation priority, genetic relationship, and potential gene flow between global goat breeds. Here, we genotyped 239 from populations Guangfeng Ganxi breeds using GoatSNP50 BeadChip. The population structure, selection signatures introgression these were analyzed in context 36 First, showed that had largest effective sizes across 13 generations ago. Nevertheless, have recently experienced a high degree...