A5059772228- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related molecular mechanisms research
- Genetics and Plant Breeding
- Meat and Animal Product Quality
- Metabolomics and Mass Spectrometry Studies
- Animal Nutrition and Physiology
- Gut microbiota and health
- Animal Behavior and Welfare Studies
- Genetic Associations and Epidemiology
- Genomic variations and chromosomal abnormalities
- Physiological and biochemical adaptations
- Mitochondrial Function and Pathology
- Ruminant Nutrition and Digestive Physiology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Congenital heart defects research
- Peroxisome Proliferator-Activated Receptors
- Ginseng Biological Effects and Applications
- Clostridium difficile and Clostridium perfringens research
- Reproductive Physiology in Livestock
South China Agricultural University
2018-2024
Guangxi University
2024
Chinese Academy of Fishery Sciences
2023
Key Laboratory of Guangdong Province
2021
Chinese Academy of Agricultural Sciences
2020
Institute of Animal Sciences
2020
Increasing feed efficiency is a major goal of breeders as it can reduce production cost and energy consumption. However, the genetic architecture feeding behavior traits remains elusive. To investigate in pigs, three (daily intake, number daily visits to feeder, duration each visit) two (feed conversion ratio residual intake) were considered. We performed genome-wide association studies (GWASs) five using population 1,008 Duroc pigs genotyped with an Illumina Porcine SNP50K BeadChip. A total...
Abstract Genetic mapping to identify genes and alleles associated with or causing economically important quantitative trait variation in livestock animals such as pigs is a major goal animal genetic improvement. Despite recent advances high-throughput genotyping technologies, the resolution of remains poor due part low density genotyped variant sites. In this study, we overcame limitation by developing reference haplotype panel for based on 2259 whole genome-sequenced representing 44 pig...
Gut microbiota has indispensable roles in nutrient digestion and energy harvesting, especially processing the indigestible components of dietary polysaccharides. Searching for microbial taxa functional capacity gut microbiome associated with feed efficiency (FE) can provide important knowledge to increase profitability sustainability swine industry. In current study, we performed a comparative analysis fecal 50 commercial Duroc × (Landrace Yorkshire) (DLY) pigs polarizing FE using 16S rRNA...
Intramuscular fat (IMF) is an important meat trait relevant to the processing industry and consumer acceptance. To gain a better understanding of genetic determinants IMF, we used composite strategy, including single-locus multi-locus association analyses perform genome-wide studies (GWAS) for IMF in 1,490 Duroc boars. We estimated genomic heritability be 0.23 ± 0.04. A total 30 SNPs were detected as significantly associated with IMF. Of these, five, nine, eight, 21 significant identified by...
Abstract Background More teats are necessary for sows to nurse larger litters provide immunity and nutrient piglets prior weaning. Previous studies have reported the strong effect of an insertion mutation in Vertebrae Development Associated ( VRTN ) gene on Sus scrofa chromosome 7 (SSC7) that increased number thoracic vertebrae teat pigs. We used genome-wide association (GWAS) map genetic markers genes associated with two Duroc pig populations different backgrounds. A single marker method...
Abstract Hybrid mapping is a powerful approach to efficiently identify and characterize genes regulated through mechanisms in cis. In this study, using reciprocal crosses of the phenotypically divergent Duroc Lulai pig breeds, we perform comprehensive multi-omic characterization regulatory variation across brain, liver, muscle, placenta four developmental stages. We produce one largest datasets pigs date, including 16 whole genome sequenced individuals, as well 48 bisulfite sequencing, 168...
The use of whole-genome sequence (WGS) data is expected to improve genomic prediction (GP) power complex traits because it may contain mutations that in strong linkage disequilibrium pattern with causal mutations. However, a few previous studies have shown no or small improvement accuracy using WGS data. Incorporating prior biological information into GP seems be an attractive strategy might accuracy. In this study, total 6334 pigs were genotyped 50K chips and subsequently imputed the level....
Growth traits are important economic of pigs that controlled by several major genes and multiple minor genes. To better understand the genetic architecture growth traits, we performed a weighted single-step genome-wide association study (wssGWAS) to identify genomic regions candidate associated with days 100 kg (AGE), average daily gain (ADG), backfat thickness (BF) lean meat percentage (LMP) in Duroc pig population. In this study, 3945 individuals phenotypic genealogical information, which...
Abstract Background In the process of pig breeding, average daily gain (ADG), days to 100 kg (AGE), and backfat thickness (BFT) are directly related growth rate fatness. However, genetic mechanisms involved not well understood. Copy number variation (CNV), an important source diversity, can affect a variety complex traits diseases has gradually been thrust into limelight. this study, we reported genome-wide CNVs Duroc pigs using SNP genotyping data from 6627 animals. We also performed copy...
Backfat thickness (BFT) is complex and economically important traits in the pig industry, since it reflects fat deposition can be used to measure carcass lean meat percentage pigs. In this study, all 6,550 pigs were genotyped using Geneseek Porcine 50K SNP Chip identify SNPs related BFT search for candidate genes through genome-wide association analysis two Duroc populations. total, 80 SNPs, including 39 significant 41 suggestive 6 QTLs identified significantly associated with BFT. addition,...
Genomic prediction (GP), which uses genome-wide markers to estimate breeding values, is a crucial tool for accelerating genetic progress in livestock and plant breeding. The accuracy of GP depends on several factors, including the statistical model, marker density, cross-validation strategy. This study evaluated these factors optimize eight economically important carcass body traits Duroc × (Landrace Yorkshire) (DLY) pig population. used 50 K SNP chip data from 1494 DLY pigs, were imputed...
Improving the genetic process of growth traits is one major goals in beef cattle industry, as it can increase meat production and reduce cost raising animals. Although several quantitative trait loci affecting have been identified, architecture these economically important remains elusive. This study aims to map single nucleotide polymorphisms (SNPs) genes associated with birth weight (BW), yearling (YW), average daily gain from (BYADG), body at age 18 months (18MW) a Chinese Simmental...
The Duroc × (Landrace Yorkshire) hybrid pigs (DLY) are the most popular commercial pigs, providing consumers with largest source of pork. In order to gain more insights into genetic architecture economically important traits in we performed a genome-wide association study (GWAS) using GeneSeek Porcine 50 K SNP Chip map markers and genes associated body conformation (BCT) 311 DLY pigs. quantitative analyzed included weight (BW), carcass length (CL), (BL), height (BH), mass index (BMI). BMI...
Abstract Background Carcass traits are important in pig breeding programs for improving pork production. Understanding the genetic variants underlies complex phenotypes can help explain trait variation pigs. In this study, we integrated a weighted single-step genome-wide association study (wssGWAS) and copy number (CNV) analyses to map variations genes associated with loin muscle area (LMA), depth (LMD) lean meat percentage (LMP) Duroc Results Firstly, performed analysis CNV detection using...
Duroc pigs are famous for their high growth rate, feed conversion efficiency, and lean meat percentage. Given that they have been subjected to artificial selection breeding in multiple countries, various lines with obvious differences production performance formed. In this study, we genotyped 3,770 American (AD) 2,098 Canadian (CD) using the GeneSeek Porcine SNP50 Beadchip dissect genetic potential genes of traits these two pig lines. Population structure detection showed there were...
Heterozygosity can effectively reflect the diverse models of population structure and demographic history. However, genomic distribution heterozygotes correlation between regions heterozygosity (runs heterozygosity, ROHet) phenotypes are largely understudied in livestock. The objective this study was to identify ROHet Duroc pig genome, investigate relationships eight important economic traits. Here, we genotyped 3,770 American (S21) 2,096 Canadian (S22) pigs using 50 K single nucleotide...
Runs of homozygosity (ROH) are widely used to investigate genetic diversity, demographic history, and positive selection signatures livestock. Commercial breeds provide excellent materials reveal the landscape ROH shaped during intense process. Here, we GeneSeek Porcine 50K single-nucleotide polymorphism (SNP) Chip data 3,770 American Duroc (AD) 2,096 Canadian (CD) pigs analyze genome-wide ROH. First, showed that AD had a moderate differentiation with CD pigs, more abundant diversity...
Artificial insemination plays a crucial role in pig production, particularly enhancing the genetic potential of elite boars. To accelerate progress for semen traits pigs, it is vital to understand and identify underlying markers associated with desirable traits. Herein, we genotyped 1238 Landrace boars GeneSeek Porcine SNP50 K Bead chip conducted genome-wide association studies regions candidate genes 12 Our study identified 38 SNPs analyzed Furthermore, several promising genes, including...
Abstract Background Improving feed efficiency is economically and environmentally beneficial in the pig industry. A deeper understanding of essential on many levels for its highly complex nature. The aim this project to explore relationship between fecal metabolites efficiency-related traits, thereby identifying that may assist screening pigs. Results We performed metabolomics analysis 50 individuals selected from 225 Duroc x (Landrace Yorkshire) (DLY) commercial pigs, 25 with an extremely...
Abstract Feed efficiency (FE) is an important trait in the porcine industry. Therefore, understanding molecular mechanisms of FE vital for improvement this trait. In study, 6 extreme high-FE and low-FE pigs were selected from 225 Duroc × (Landrace Yorkshire) (DLY) transcriptomic analysis. RNA-seq analysis was performed to determine differentially expressed genes (DEGs) liver tissues 12 individuals, 507 DEGs identified between (HE- group) (LE- group). A gene ontology (GO) enrichment pathway...
Chest circumference (CC), abdominal (AC), and waist (WC) are regarded as important indicators for improving economic traits because they can reflect the growth physiological status in pigs. However, genetic architecture of CC, AC, WC is still elusive. Here, we performed single-trait multi-trait genome-wide association studies (GWASs) 2,206 American origin Duroc (AOD) 2,082 Canadian (COD) As a result, one novel quantitative trait locus (QTL) on Sus scrofa chromosome (SSC) was associated with...
Internal organ weight is an essential indicator of growth status as it reflects the level and development in pigs. However, associated genetic architecture has not been well explored because phenotypes are difficult to obtain. Herein, we performed single-trait multi-trait genome-wide association studies (GWASs) map markers genes with six internal traits (including heart weight, liver spleen lung kidney stomach weight) 1518 three-way crossbred commercial In summation, GWASs identified a total...