A5101721704- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Genetic Mapping and Diversity in Plants and Animals
- RNA Research and Splicing
- Genetic and phenotypic traits in livestock
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Cancer-related gene regulation
- Lung Cancer Research Studies
- Sesquiterpenes and Asteraceae Studies
- Peroxisome Proliferator-Activated Receptors
- Natural product bioactivities and synthesis
- Cancer, Lipids, and Metabolism
- Cancer Risks and Factors
- Breast Cancer Treatment Studies
- Tannin, Tannase and Anticancer Activities
- Animal Genetics and Reproduction
- Mechanisms of cancer metastasis
- Nutrition, Genetics, and Disease
- CAR-T cell therapy research
- Genomic variations and chromosomal abnormalities
- Cancer Immunotherapy and Biomarkers
Central South University
2018-2025
Xinjiang Medical University
2025
Vanderbilt University Medical Center
2015-2024
Hunan Cancer Hospital
2018-2023
Shenyang Pharmaceutical University
2023
South China Agricultural University
2020-2022
Jianghan University
2022
Jiangsu Province Hospital
2015-2021
Key Laboratory of Guangdong Province
2021
Vanderbilt University
2014-2019
Ovarian cancer is the fifth leading cause of female death globally due to its low survival rates. Thus, improved approaches for ovarian detection are urgently needed. MicroRNAs as a new class biomarkers have been explored in recent studies. This study was trying identify and validate two kinds serum microRNA (miR-200c miR-141) cancer. We extracted samples from 74 epithelial patients, 19 borderline cancer, 50 healthy controls. Relative expression these miRNA markers were measured by...
Abstract Background Lung cancer is one of the most common malignant tumors threatening human health. The aim this study was to investigate function miR‐21‐5p in lung progression. Methods We analyzed expression levels tissues and cell lines. qRT‐PCR MTT assays were performed after transfection with mimic, inhibitor negative control into cells. Results Luciferase reporter showed directly target SMAD7. significantly suppressed proliferation, invasion migration. found that SMAD7 upregulated...
Growth traits are important economic of pigs that controlled by several major genes and multiple minor genes. To better understand the genetic architecture growth traits, we performed a weighted single-step genome-wide association study (wssGWAS) to identify genomic regions candidate associated with days 100 kg (AGE), average daily gain (ADG), backfat thickness (BF) lean meat percentage (LMP) in Duroc pig population. In this study, 3945 individuals phenotypic genealogical information, which...
Abstract Background In the process of pig breeding, average daily gain (ADG), days to 100 kg (AGE), and backfat thickness (BFT) are directly related growth rate fatness. However, genetic mechanisms involved not well understood. Copy number variation (CNV), an important source diversity, can affect a variety complex traits diseases has gradually been thrust into limelight. this study, we reported genome-wide CNVs Duroc pigs using SNP genotyping data from 6627 animals. We also performed copy...
Backfat thickness (BFT) is complex and economically important traits in the pig industry, since it reflects fat deposition can be used to measure carcass lean meat percentage pigs. In this study, all 6,550 pigs were genotyped using Geneseek Porcine 50K SNP Chip identify SNPs related BFT search for candidate genes through genome-wide association analysis two Duroc populations. total, 80 SNPs, including 39 significant 41 suggestive 6 QTLs identified significantly associated with BFT. addition,...
Nasopharyngeal carcinoma (NPC) is a kind of malignant tumor with high metastasis. Circular RNAs (circRNAs) are involved in progression, but their functions and mechanisms not well understood. Vasculogenic mimicry (VM) has been discovered as an alternative way to supply nutrition accelerate including NPC. We previously found that circCCNB1 (derived from cyclin B1) could inhibit the migration invasion NPC cells by binding nuclear factor 90 (NF90), however, whether additional biological still...
Abstract Background Carcass traits are important in pig breeding programs for improving pork production. Understanding the genetic variants underlies complex phenotypes can help explain trait variation pigs. In this study, we integrated a weighted single-step genome-wide association study (wssGWAS) and copy number (CNV) analyses to map variations genes associated with loin muscle area (LMA), depth (LMD) lean meat percentage (LMP) Duroc Results Firstly, performed analysis CNV detection using...
Long noncoding RNAs (lncRNAs) have been shown to play important roles in human cancers, including esophageal squamous cell carcinoma (ESCC). We previously demonstrated that a novel lncRNA, lnc-ABCA12-3, was overexpressed ESCC tissues. However, the exact function of lnc-ABCA12-3 is unknown. In current study, we aimed evaluate expression and explore potential mechanism migration, invasion, proliferation. showed upregulated tumor tissues lines. The increased positively associated with advanced...
Abstract Early detection is critical for improving pancreatic cancer prognosis. Our study aims to identify circulating microRNAs (miRNAs) associated with risk. The two‐stage used plasma samples collected ≤5 years prior diagnosis, from case–control studies nested in five prospective cohort studies. discovery stage included 185 pairs the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Replication comprised 277 Shanghai Women's Health Study/Shanghai Men's Study, Southern...
Endometrial cancer (EC) is the most common gynecological malignancy. Recent studies have uncovered miRNA acted a striking role in predicting prognosis of multiple tumors. Over 500 EC samples were selected from Cancer Genome Atlas (TCGA) database. Univariate, LASSO and multivariate Cox regression analysis employed to screen out prognosis-involved miRNAs. Kaplan-Meier (K-M) time-dependent receiver operation characteristic (ROC) curves conducted reveal survival assess accuracy signature. The...
Although reproductive factors have been repeatedly associated with lung cancer risk, no study to date has directly evaluated the relationship endogenous sex hormones nor aromatase activity in postmenopausal never-smoking women. A case-control of 397 incident cases and their individually matched controls, nested within Shanghai Women's Health Study, was conducted among women who were lifetime never smokers. Prediagnostic concentrations quantitated using LC-MS/MS assays plasma. The...
Esophageal squamous cell carcinoma (ESCC) represents a major malignancy with poor clinical outcomes. Long noncoding RNAs (lncRNAs) are known to regulate the development and progression of multiple cancers. However, how lncRNAs involved in ESCC is currently undefined.LIPH-4 levels tissue specimens cells were assessed by qRT-PCR. The biological function LIPH-4 was examined animal studies, applying CCK-8, EdU, colony formation flow cytometry assays as well xenograft model experiments....
Abstract Feed efficiency (FE) is an important trait in the porcine industry. Therefore, understanding molecular mechanisms of FE vital for improvement this trait. In study, 6 extreme high-FE and low-FE pigs were selected from 225 Duroc × (Landrace Yorkshire) (DLY) transcriptomic analysis. RNA-seq analysis was performed to determine differentially expressed genes (DEGs) liver tissues 12 individuals, 507 DEGs identified between (HE- group) (LE- group). A gene ontology (GO) enrichment pathway...
Objectives Neoadjuvant chemoimmunotherapy is the optimal choice in treatment of NSCLC; however, number therapeutic cycles remains unclear. The primary aim this study was to determine neoadjuvant NSCLC. Methods This a real-world clinical analysis that included patients who received followed by surgery from January 2020 August 2022. Patients were divided into two groups based on cycles: 2-cycle group and 3-4-cycles group. endpoint major pathological response (MPR) rate. Results A total 251...
Abstract Esophageal cancer (EC) is a serious malignancy and that the fifth leading cause of cancer-related death worldwide. squamous cell carcinoma (ESCC) main subtype EC in China. In recent years, long non-coding RNAs (lncRNAs) have demonstrated to be novel tumor-associated regulatory factors. However, functions mechanisms lncRNAs ESCC not been fully understood. this study, we attempted construct Genome-wide expression profiles their potential ESCC. By using microarray, found total 2,366...
Parthenolide (PT), the effective active ingredient of medicinal plant, feverfew (Tanacetum parthenium), has been used as an anti-inflammatory drug due to its involvement in inhibition NF-кB pathway. Moreover, recent studies have demonstrated anti-tumor effect PT several cancers. However, on esophageal carcinoma remains unclear date. In this study, we examined inhibitory effects and underlying mechanism action human squamous cell (ESCC) cells - Eca109 KYSE-510.The proliferation ability...