A5043962836- Radiomics and Machine Learning in Medical Imaging
- Corneal surgery and disorders
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- AI in cancer detection
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- MRI in cancer diagnosis
- Corneal Surgery and Treatments
- Medical Imaging Techniques and Applications
- Breast Cancer Treatment Studies
- Lung Cancer Treatments and Mutations
- Digital Radiography and Breast Imaging
- Glaucoma and retinal disorders
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Ocular Surface and Contact Lens
- Prostate Cancer Diagnosis and Treatment
- Ophthalmology and Visual Impairment Studies
- Cancer Immunotherapy and Biomarkers
- Breast Lesions and Carcinomas
- HER2/EGFR in Cancer Research
- Esophageal and GI Pathology
- Metastasis and carcinoma case studies
- Colorectal Cancer Treatments and Studies
Hunan Cancer Hospital
2016-2025
Central South University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2024
Sichuan Agricultural University
2024
Shanghai Medical College of Fudan University
2014-2024
Fudan University Shanghai Cancer Center
2013-2024
Northern Jiangsu People's Hospital
2019-2024
Wenzhou Medical University
2022-2024
First Affiliated Hospital of Wenzhou Medical University
2022-2024
Peking Union Medical College Hospital
2021-2024
Purpose Neoadjuvant chemoimmunotherapy (nCIT) is becoming a new therapeutic frontier for resectable esophageal squamous cell carcinoma (ESCC); however, crucial details and technical know-how regarding surgical techniques the perioperative challenges following nCIT remain poorly understood. The study investigated compared advantages disadvantages of esophagectomy with neoadjuvant chemotherapy (nCT) chemoradiotherapy (nCRT). Methods We retrospectively analyzed data patients initially diagnosed...
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and ultrasound (US), which are two common modalities for clinical breast tumor diagnosis besides Mammograms, can provide different complementary information the same regions. Although many machine learning methods have been proposed classification based on either single modality, it remains unclear how to further boost performance by utilizing paired multi-modality with dimensions. In this paper, we propose MRI-US network...
Background: The purpose of this study was to validate B7-H3 as a new cancer-specific endothelial marker in clear cell renal carcinoma. Methods: expression patterns were compared between cancer and paired adjacent normal parenchyma by immunohistochemistry paraffin-embedded specimens from 200 consecutive patients with carcinoma January December 2010. Four corpus luteum used physiologic angiogenesis controls. messenger (m)RNA levels representing circulating cells analyzed 24 peripheral blood...
Abstract Background The standard treatment for elderly patients with unresectable locally advanced esophageal squamous cell carcinoma (ESCC) is definitive chemoradiotherapy S-1. However, the 3-year overall survival (OS) limited to approximately 40%. Tislelizumab first- and second-line ESCC tolerable toxicity. In this study, we aimed explore a new curative strategy in by combining tislelizumab chemoradiotherapy. Methods This study an open-label, multicenter, investigator-initiated phase II...
The effect of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT)-guided dose-painting intensity-modulated radiation therapy (IMRT) in locoregionally advanced nasopharyngeal carcinoma (NPC) is unclear. This study aimed to assess the efficacy and toxicity such combination.From 2012 2014, 213 patients with stage III-IVB NPC received chemoradiotherapy by PET/CT-guided DP-IMRT (group A, n = 101) or CT-based IMRT B, 112). In group subvolume GTVnx-PET (gross tumor...
Bombyx mori nuclear polyhedrosis virus (BmNPV) is an important pathogen of silkworms. Despite extensive studies in recent decades, the interaction between BmNPV and host cells still not clearly understood. Autophagy intrinsic innate immune mechanism it controls infection autonomously virus-infected cells. In this study, we found that could trigger autophagy, as demonstrated by formation autophagosomes, fluorescent Autophagy-related gene 8-Green Fluorescent Protein (ATG8-GFP) punctate,...
Corneal biomechanical properties are important for the diagnosis of corneal diseases, individualized design and prognosis surgery. Clinical available devices such as Ocular Response Analyzer (ORA) Visualization Scheimpflug Technology (Corvis ST) can provide biomechanics related parameters, while elastic modulus cannot be extracted directly from them at present. The aim this study is to suggest a method determine based on results Corvis ST test according Reissner's theory relation between...
Background Neoadjuvant chemoimmunotherapy becomes more widespread in the treatment of NSCLC, but few studies have reported details surgical techniques and perioperative challenges following neoadjuvant until now. The primary aim our study was to address feasibility safety pulmonary resection after via different approaches, video-assisted thoracoscopic surgery (VATS) open thoracotomy. Methods Patients with an initial diagnosis clinical stage IB-IIIB(T3-4N2) who received between January 2019...
Abstract Background The impact of neoadjuvant chemoimmunotherapy on pulmonary resection and related outcomes had been poorly reported in previous studies. present study aims to clarify the efficacy safety chemoimmunotherapy, intraoperative difficulty following surgery, comparison with chemotherapy alone non‐small cell lung cancer (NSCLC). Methods Patients newly diagnosed clinical stages IB–IIIB(T3‐4N2) NSCLC, received + PD‐1 inhibitors (PD‐1 Chemo group) or (Chemo followed by surgery between...
ABSTRACTABSTRACTThis study aims to evaluate the expression of antioncogene phosphatase and tensin (PTEN) homologue survivin, a protein encoded by anti-apoptotic gene baculoviral inhibitor apoptosis repeat containing 5 (BIRC5), in progression cervical neoplasia elucidate relationship between PTEN survivin based on clinicopathological features squamous cell carcinoma uterine cervix. A total 20 patients with ectropion metaplasia, 30 intraepithelial neoplasia, 49 were enrolled study....
This study conducted a retrospective multicenter analysis to investigate the clinicopathological features, optimal therapeutic strategy, and prognosis of spindle cell carcinoma (SpCC) esophagus. A total 71 patients with esophageal SpCC from 3 large cancer centers in China were systematically analyzed. All received curative resection, 13 adjuvant radiotherapy 15 combination chemotherapy. Additionally, 1852 typical SCC (SCC) selected as controls this study. mostly presented polypoid appearance...
// Li Cao 1 , Chaowu Chen 2 Haihang Zhu Xuewen Gu Denghao Deng Xiuchun Tian Jun Liu Qin Xiao Department of Pathology, Clinical Medical College Yangzhou University, Subei People's Hospital Jiangsu Province, Yangzhou, 225001, P.R. China Gastroenterology, Correspondence to: Chen, email: doctorchencw@163.com Keywords: gastric cancer, MMP16, survival analysis, proliferation, invasion Received: March 30, 2016 Accepted: June 06, Published: 20, ABSTRACT Matrix metalloproteinases (MMPs) are closely...
To compare the dynamic corneal response (DCR) and tomographic parameters of thin normal cornea (TNC) with thinnest thickness (TCT) (≤ 500 µm), forme fruste keratoconus (FFKC) mild (MKC) had their central (CCT) matched by Scheimpflug imaging (Pentacam) visualization technology (Corvis ST).CCT were in 50 eyes FFKC, MKC, 53 TNC TCT ≤ µm. The differences DCR among three groups compared. receiver operating characteristic (ROC) curve was used to analyze diagnostic significance these parameters....
Abstract Objective To more comprehensively evaluate the ability of parameters reflecting morphological and biomechanical properties cornea to distinguish clinical keratoconus (CKC) forme fruste (FFKC) from normal. Methods Normal eyes ( n = 50), CKC 45) FFKC 15) were analyzed using Pentacam, Corvis ST ORA. Stepwise logistic regression all was performed obtain optimal combination model capable distinguishing CKC, normal, named SLR1 SLR2, respectively. Receiver operating characteristic (ROC)...
Follicular dendritic cell sarcoma is a rare malignant neoplasm and little known about its radiological features.We present here four cases of follicular sarcomas we provide the image characteristics these tumors to help radiologists recognize this entity when making diagnosis.
To assess the value of radiomics based on multiphases contrast-enhanced magnetic resonance imaging (CE-MRI) for early prediction pathological complete response (pCR) to neoadjuvant therapy (NAT) in patients with human epithelial growth factor receptor 2 (HER2) positive invasive breast cancer.A total 127 newly diagnosed primary HER2 cancer underwent CE-MRI before NAT and performed surgery after NAT. Radiomic features were extracted from 1st postcontrast phase (CE1) multi-phases...
Toripalimab, a novel PD-1 antibody, is approved for treatment of multiple solid tumors; however, its neoadjuvant use with chemotherapy triple-negative breast cancer (TNBC) remains unevaluated. Additionally, induction followed by de-escalation immunotherapy underexplored. Therefore, we conducted phase II trial investigating chemoimmunotherapy regimen including early-stage TNBC.