A5100323350- Lung Cancer Treatments and Mutations
- Corneal surgery and disorders
- Metabolism, Diabetes, and Cancer
- Glaucoma and retinal disorders
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Corneal Surgery and Treatments
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Pancreatic function and diabetes
- Pancreatic and Hepatic Oncology Research
- HER2/EGFR in Cancer Research
- Ocular Surface and Contact Lens
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Cancer, Lipids, and Metabolism
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Ophthalmology and Visual Impairment Studies
- Folate and B Vitamins Research
- Retinal Diseases and Treatments
- Cell death mechanisms and regulation
- Diabetes and associated disorders
- Neuroblastoma Research and Treatments
ZheJiang Institute For Food and Drug Control
2024
Sixth Affiliated Hospital of Kunming Medical University
2024
Soochow University
2024
Xuzhou Medical College
2024
First Affiliated Hospital of Soochow University
2024
Northwestern University
2024
Capital Medical University
2014-2023
Peking University
2008-2023
Beijing Anzhen Hospital
2023
Beijing Chest Hospital
2012-2023
TGF-beta-activated kinase-1 (TAK1), also known as MAPKK kinase-7 (MAP3K7), is a candidate effector of multiple circuits in cardiac biology and disease. Here, we show that inhibition TAK1 mice by cardiac-specific dominant-negative mutation evokes electrophysiological biochemical properties reminiscent human Wolff-Parkinson-White syndrome, arising from mutations AMP-activated protein kinase (AMPK), most notably, accelerated atrioventricular conduction impaired AMPK activation. To test...
As a debilitating condition that can impact whole spectrum of people and involve multi-organ systems, long COVID has aroused the most attention than ever. However, mechanisms are not clearly understood, underlying biomarkers affect long-term consequences COVID-19 paramount to be identified.
Metformin may exert the anticancer effect on multiple types of cancers and some potential mechanisms have been suggested. Our study was designed to determine metformin cell autophagy autophagic flux via AMPK-mTOR signaling pathway in human hepatocellular carcinoma (HCC) cells.MHCC97H HepG2 lines were cultured treated without with at various concentrations (2, 5, 10 20 mM) for 48 h. Then, mM determined as optimal concentration HCC cells 12, 24, 48, 72 MTT assay used assess viability Western...
// Zhao Liu 1 , Shasha Qi 2 Xingbo Mingjiang Li Sentai Ding Jiaju Lu and Hui Zhang Department of Urology, Shandong Provincial Hospital Affiliated to University, Jinan, Shandong, People's Republic China Obstetrics Gynecology, Correspondence to: Zhang, email: Keywords : metformin, βKlotho, 17β-estradiol, epithelial-mesenchymal transition, endometrial adenocarcinoma Received August 14, 2015 Accepted January 19, 2016 Published 27, Abstract The potential role metformin in treating cancer remains...
Epstein-Barr virus (EBV) was the first identified to encode microRNAs (miRNAs). Both of viral and human cellular miRNAs are important in EBV infection. However, dynamic expression profile during primary infection unknown. This study aimed investigate infectious mononucleosis (IM) caused by infection.The levels were measured fifteen pediatric IM patients at three different time-points. Fifteen healthy children who seropositive for enrolled control group. Relative detected quantitative...
In normal endometrium, stromal factors regulate the growth of epithelial cells. However, cells in endometriotic lesions display increased proliferation and decreased apoptosis. This work tested hypothesis that endometriosis lose ability to survival signaling cell Primary normal, eutopic ectopic were cultured presence medium conditioned by endometrial Endometriotic showed higher Survivin expression than Conditioned (CM) from or significantly inhibited AKt phosphorylation CM did not have an...
Monocytes play important roles in antigen presentation and cytokine production to achieve a proper immune response, are therefore largely implicated the development progression of autoimmune diseases.The aim this study was analyze change intermediate (CD14+CD16+) monocyte subset children with recent-onset type 1 diabetes mellitus (T1DM) its possible association clinical parameters reflecting islet β-cell dysfunction.Compared age-and sex-matched healthy controls, monocytes were expanded T1DM,...
To compare the dynamic corneal response (DCR) and tomographic parameters of thin normal cornea (TNC) with thinnest thickness (TCT) (≤ 500 µm), forme fruste keratoconus (FFKC) mild (MKC) had their central (CCT) matched by Scheimpflug imaging (Pentacam) visualization technology (Corvis ST).CCT were in 50 eyes FFKC, MKC, 53 TNC TCT ≤ µm. The differences DCR among three groups compared. receiver operating characteristic (ROC) curve was used to analyze diagnostic significance these parameters....
Abstract Objective To more comprehensively evaluate the ability of parameters reflecting morphological and biomechanical properties cornea to distinguish clinical keratoconus (CKC) forme fruste (FFKC) from normal. Methods Normal eyes ( n = 50), CKC 45) FFKC 15) were analyzed using Pentacam, Corvis ST ORA. Stepwise logistic regression all was performed obtain optimal combination model capable distinguishing CKC, normal, named SLR1 SLR2, respectively. Receiver operating characteristic (ROC)...
Background: The occurrence and development of solid tumors depend on the blood supply in tumor microenvironment (TME). Blocking angiogenesis is a new therapeutic strategy to inhibit growth. anti-angiogenic drug bevacizumab has been approved for gynecological malignancies, especially advanced recurring cervical cancers ovarian (OC). Studies OC have shown limited effect general population, with slight improvement progression-free survival (PFS) no overall (OS). This might be related...
To analyze the trends of glaucoma surgery procedures over past 5 years among hospitals across major provinces in China.This was a retrospective observational study based on medical records. We obtained annual numbers commonly performed incisional surgeries from 57 30 provincial regions Chinese Glaucoma Study Consortium (CGSC) January 2015 to September 2019. The trend analyzed by Cochrane-Armitage test.Trabeculectomy, cataract extraction combined with goniosynechialysis, trabeculectomy, and...
Purpose: To report surgical outcomes of 25-gauge pars plana vitrectomy using air as an internal tamponade for patients with primary rhegmatogenous retinal detachment (RRD). Methods: A retrospective clinical study 59 eyes consecutive presented RRD at the Beijing Tongren Eye Center in China. From August 2016 to May 2018, medical records who underwent were reviewed. The main outcome measures and final anatomical success (retinal re-attachment) rates, postoperative complications. Results: Of...
Objective: The primary objective was to determine the prognostic significance of circulating tumor DNA (ctDNA) in patients receiving neoadjuvant chemotherapy (NAC) for localized pancreatic ductal adenocarcinoma (PDAC) using digital droplet polymerase chain reaction (ddPCR). Summary and Background Data: Increasingly, ctDNA is being used clinical decision-making a variety solid malignancies. However, detection value KRAS as assessed by ddPCR during NAC has yet be characterized. Methods:...
Brucellosis is a highly contagious zoonosis caused by Brucella. Brucella can invade and persist inside host cells, which results in chronic infection. We constructed AIR interference overexpression lentiviruses to acquire interference, overexpression, rescue stable expression cell lines. also established melitensis 16M-infected macrophage model, was treated with either the vehicle control or NAC (ROS scavenger N-acetylcysteine (NAC) for 0, 3, 6, 12, 24 h. Confocal laser microscopy,...