A5101939307- Cancer, Lipids, and Metabolism
- Yersinia bacterium, plague, ectoparasites research
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Forensic and Genetic Research
- Curcumin's Biomedical Applications
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Forensic Anthropology and Bioarchaeology Studies
- Bioactive Compounds and Antitumor Agents
- Immune cells in cancer
- Vacuum and Plasma Arcs
- Cancer therapeutics and mechanisms
- RNA Interference and Gene Delivery
- Retinoids in leukemia and cellular processes
- Cancer Mechanisms and Therapy
- Peroxisome Proliferator-Activated Receptors
- Leech Biology and Applications
- Coconut Research and Applications
- Advances in Cucurbitaceae Research
- Cytokine Signaling Pathways and Interactions
- Inflammatory mediators and NSAID effects
- RNA Research and Splicing
- Advanced Sensor Technologies Research
Shanghai University of Traditional Chinese Medicine
2019-2024
Affiliated Hospital of Qingdao University
2018-2024
Qinghai University
2024
Qingdao University
2018-2024
The Fourth People's Hospital of Zibo City
2022
Xinjiang Institute of Ecology and Geography
2021
Chinese Academy of Sciences
2021
State Key Laboratory of Proteomics
2016-2018
Czech Academy of Sciences, Institute of Biotechnology
2018
Army Medical University
2011-2017
The H19 lncRNA, a highly abundant and conserved imprinted gene, has been implicated in many essential biological processes diseases. However, the function of heart remains unknown. In this study, we investigated underlying mechanism regulating cardiomyocyte hypertrophy.We first detected expression its encoded miR-675 both normal diseased hearts verified their up-regulations pathological cardiac hypertrophy failure. Adenovirus-mediated siRNA-mediated silence showed that overexpression reduced...
Hypoxia is associated with poor prognosis and therapeutic resistance in cancer patients. Accumulating evidence has shown that microRNA (miRNA) plays an important role the acquired drug colorectal carcinoma (CRC). However, of miRNA hypoxia-induced CRC remains to be elucidated. Here, we identified a hypoxia-triggered feedback loop involves hypoxia-inducible transcription factor 1α (HIF-1α)-mediated repression miR-338-5p confers CRC. In this study, unbiased array screening revealed...
The tumor suppressor gene Wnt inhibitory factor-1 (WIF-1) has been found to be promoter hypermethylated and silenced in lung cancer cell lines tissues. Curcuminoids are major active components of the spice turmeric, have recently reported potential hypomethylation agents. In present study, effects three curcuminoids, curcumin, demethoxycurcumin bisdemethoxycurcumin, were compared vitro using ELISA, their demethylation was confirmed by methylation-specific PCR. It that bisdemethoxycurcumin...
Abstract Background The spleen is the largest secondary lymphoid organ and main site where stress erythropoiesis occurs. It known that hypoxia triggers expansion of erythroid progenitors; however, its effects on splenic gene expression are still unclear. Here, we examined global patterns by time-series RNA-seq after exposing mice to for 0, 1, 3, 5, 7 13 days. Results Morphological analysis showed 3rd day there was a significant increase in index proliferation progenitors. RNA-sequencing...
Epithelial ovarian cancer (EOC) is one of the most prevalent gynaecological cancers. Euxanthone, an active ingredient medicinal plant Polygala caudata , exhibits a selective cytotoxic effect in tumour cells. The present study was aimed to determine whether euxanthone could suppress growth, and relevant mechanism. Two EOC cell lines, SKOV3 A2780, were used as vitro model treated with euxanthone. Cell viability apoptosis assayed using Counting Kit‐8 (CCK‐8) Annexin‐V FITC/PI staining,...
Abstract The Xianbei existed as a remarkable nomadic tribe in northeastern China for three dynasties: the Han, Jin, and Northern‐Southern dynasties (206 BC to 581 AD) Chinese history. A very important subtribe of is Murong Xianbei. To investigate genetic structure population address its relationships with other tribes at molecular level, we analyzed control region sequences coding‐region single nucleotide polymorphism markers mtDNA from remains Lamadong cemetery Three‐Yan Culture population,...
Based on a steady-state 3-D magnetohydrodynamic (MHD) model, the high-current vacuum arc (HCVA) under combined effect of actual magnetic field (MF) and external transverse MF (ETMF) is simulated. The generated by cup-type axial contact system commonly used in commercial circuit breakers. ETMF may cause deflection column, which main reason deflected erosion. According to some experimental results, electron temperature HCVA assumed be uniform equal 3 eV. Therefore, MHD model simplified...
Based on a 3-D steady magnetohydrodynamic model, the high current vacuum arc subjected to realistic spatial magnetic field generated by cup-type contacts was simulated. The influence of profile plasma's rotation behavior analyzed. distribution azimuthal velocity anode side under quite different from that uniform axial field.
To explore how AADAC functions in the malignant progression of ovarian cancer, and effect on drug therapeutic activity against cancer cells.AADAC level tumor normal samples from TCGA-OV dataset its survival significance were analyzed by bioinformatics methods. Signaling pathway enrichment analysis for high- low-AADAC patients was achieved using GSEA software. expression cell lines with different treatments evaluated via qRT-PCR. Cell proliferative ability assessed MTT assay migratory...
Intestinal bacteria are considered the "second genome" of host, playing a crucial physiological role in assisting host degrading plant secondary compounds, nutrient absorption, immune regulation, and other aspects. To explore effects