A5102952120- Neonatal Respiratory Health Research
- Antibiotic Resistance in Bacteria
- RNA modifications and cancer
- Bacterial biofilms and quorum sensing
- Lung Cancer Treatments and Mutations
- Congenital Diaphragmatic Hernia Studies
- Cancer-related molecular mechanisms research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Cancer Genomics and Diagnostics
- Respiratory and Cough-Related Research
- Sirtuins and Resveratrol in Medicine
- Tracheal and airway disorders
- Tissue Engineering and Regenerative Medicine
- Asthma and respiratory diseases
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Pediatric health and respiratory diseases
- Biochemical and Structural Characterization
- Epigenetics and DNA Methylation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Antimicrobial Peptides and Activities
- PI3K/AKT/mTOR signaling in cancer
- Medical Research and Treatments
Army Medical University
2016-2025
Southwest Hospital
2008-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022
Chongqing Medical University
2022
Indiana State University
2019
Huaibei Normal University
2015
Irreversible destruction of bronchi and alveoli can lead to multiple incurable lung diseases. Identifying stem/progenitor cells with regenerative capacity utilizing them reconstruct functional tissue is one the biggest hopes reverse damage cure such Here we showed that a rare population SOX9+ basal (BCs) located at airway epithelium rugae regenerate adult human lung. Human BCs be readily isolated by bronchoscopic brushing indefinitely expanded in feeder-free condition. Expanded give rise...
Adult lung resident stem/progenitor cells, including P63 + progenitor have demonstrated the capacity for regeneration of epithelium in preclinical models. Here, we report a clinical trial intrapulmonary cell transplantation 28 participants with stage II to IV chronic obstructive pulmonary disease (COPD). Autologous cells were isolated from airway basal layer intervention group via bronchoscopic brushing, cultured 3 5 weeks, and then transplanted back into lungs bronchoscopy at 0.7 × 10 6 5.2...
Pseudomonas aeruginosa strain 10265 was recovered from a patient with pneumonia in Chinese public hospital, and it displays the carbapenem resistance phenotype due to acquisition of non-conjugative but mobilizable IncP-6-type plasmid p10265-KPC. p10265-KPC carries Tn5563-borne defective mer locus, novel ΔISEc33-associated bla KPC-2 gene cluster without paired inverted repeats direct at both ends. Mobilization this element would be attributed homologous recombination-based insertion foreign...
The NAD-dependent histone deacetylase sirtuin 2 (SIRT2) plays critical roles in mitosis and cell cycle progression recently was shown to suppress tumor growth be downregulated several types of cancers. However, the underlying mechanism SIRT2 downregulation remains unknown. In this study, using bioinformatics, gene expression profiling, protein overexpression approaches, migration assays, we showed that E3 ubiquitin ligase 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase degradation...
Background Neutrophil extracellular trap (NET) correlate with chronic obstructive pulmonary disease (COPD) severity. Platelets can promote NET generation. However, serotonin alone or serotonin-deficient platelets do not adequately production. The metabolism of to 5-hydroxyindoleacetic acid (5-HIAA) in may be the key this difference.
Abstract Background While blood‐derived cell‐free DNA has been shown to be a candidate biomarker able provide diagnostic and prognostic insight in cancer patients, little is known regarding the potential application of urine (ucfDNA) diagnosis cancer. Thus, aim this study was investigate ucfDNA concentration integrity index as biomarkers for early detection non‐small‐cell lung (NSCLC). Methods Urine samples were collected from 35 healthy controls 55 NSCLC patients at various tumor node...
Existing methods often fail to recognize the conversions for biological roles of pairs genes and microRNAs (miRNAs) between tumor normal samples. We have developed a novel cluster scoring method identify messenger RNA (mRNA) miRNA interaction clusters while considering samples jointly. Our has identified 54 significant 15 cancer types selected from The Cancer Genome Atlas project. also determined shared across and/or subtypes. In addition, we compared gene overlap lists in our liver...
This study is aimed at characterizing the human distal airway stem cells (DASCs) and assessing their therapeutic potential in patients with chronic, degenerative lung diseases. These findings will provide a comprehensive understanding for further clinical applications utilizing autologous as intervention respiratory DASCs were isolated from healthy subjects or diagnosed bronchiectasis, chronic obstructive pulmonary diseases (COPD), interstitial disease (ILD). Differentiation capacity, key...
Aim: To explore the role of urine cell-free DNA (ucfDNA) concentration and integrity indexes as potential biomarkers for lung cancer diagnosis. Materials & methods: Quantitative real-time PCR targeting Arthrobacter luteus (ALU) repeats at three size fragments (ALU-60, 115 247 bp) was performed in 55 patients 35 healthy individuals. Results: ucfDNA were significantly higher than controls. The area under receiver operating characteristic curve differentiating with stage I/II from controls by...
Phosphatidylinositol-3-OH kinase and RAS-activated signaling pathways play an important role in tumor formation.Abnormalities relevant genes essential roles the occurrence development of many human cancers.Studies breast cancer have mainly focused on women western countries, but few studies examined frequency mutations PIK3CA, BRAF, KRAS Chinese patients.In this study, we conducted sequence analysis determined relationships with from Qinghai.DNA was extracted 25 cases tissue samples.PIK3CA,...
Methicillin‑resistant Staphylococcus aureus (S. aureus; MRSA) is one of the most common bacterial pathogens and MRSA infections are characterized by high mortality rates. Antimicrobial peptides considered promising drugs for treatment resistant strains S. aureus. The present study aimed to examine antimicrobial activity L12 against numerous species using broth microdilution method. Furthermore, synergistic effect combined with various antibacterial was tested, its mechanism investigated a...
Acinetobacter baumannii is an important nosocomial pathogen able to cause severe infections in intensive care unit (ICU). However, there a lack of analysis regarding the epidemiology and resistance A. respiratory department ICUs. In this study, clinical isolates were collected from ICU Southwest Hospital January 2009 December 2010, social demographic information patients whom taken was obtained system. The minimal inhibitory concentration (MIC) determined by agar dilution method....
Purpose: The purpose of this study was to assess the effect a lavage solution containing methoxypolyethylene glycol 4-(3,4-dihydroxyphenethylamino)-4-oxobutanoate (MDO) for whole lung (WLL) in dogs after inhalation depleted uranium (DU) dust at dose 30 mgUkg−1.Materials and methods: WLL performed using solutions made normal saline (saline group) or plus MDO (MDO 2 days post-DU exposure. Meanwhile, control group set up without any treatment.Results: At 10 exposure, groups had lower DU content...
Abstract Introduction Bronchiectasis is a common condition and leading cause of respiratory morbidity mortality. The treatment method for bronchiectasis mainly symptomatic or surgery; however, this extremely prone to recurrence. Objectives To preliminarily evaluate the safety efficacy applying SOX9 + autologous airway basal cells (BCs) in patients with bronchiectasis. Methods BCs were isolated from microscale tissue grade 3‐5 bronchus by bronchoscopic brushing expanded vitro approximately 4...