A5085716641- Head and Neck Cancer Studies
- MicroRNA in disease regulation
- Lung Cancer Research Studies
- RNA modifications and cancer
- Cancer Research and Treatments
- Dermatology and Skin Diseases
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Genetic and rare skin diseases.
- Autoimmune and Inflammatory Disorders
- Lung Cancer Treatments and Mutations
- Artificial Intelligence in Games
- Vascular Malformations and Hemangiomas
- Nonmelanoma Skin Cancer Studies
- Full-Duplex Wireless Communications
- Immunotherapy and Immune Responses
- Advanced Materials and Mechanics
- Skin Protection and Aging
- Autoimmune Bullous Skin Diseases
- Antenna Design and Analysis
- Skin and Cellular Biology Research
- Gear and Bearing Dynamics Analysis
- Healthcare Systems and Technology
- Dysphagia Assessment and Management
- Mechanical Failure Analysis and Simulation
Eisai (Japan)
2024
University of California, San Diego
2021-2023
National University of Singapore
2023
University of Pittsburgh
2023
Nanjing Foreign Language School
2022
Coventry and Warwickshire Partnership NHS Trust
2021
Precision for Medicine (United States)
2021
University of California, Irvine
2019
Royal Prince Alfred Hospital
2018
SUNY Downstate Health Sciences University
2015-2017
The standard of care for the definitive treatment locoregionally advanced cervical cancer is external beam radiation therapy (EBRT) with concurrent chemotherapy followed by a brachytherapy boost. Historically, EBRT was delivered via two-dimensional technique based primarily on bony landmarks. This gave way to three-dimensional conformal therapy, which allows dose calculation and adjustment individual tumour patient anatomy. Further technological advances have established intensity-modulated...
Abstract Imiquimod is a TLR7/8 agonist that has anticancer therapeutic efficacy in the treatment of precancerous skin lesions and certain nonmelanoma cancers. To test our hypothesis imiquimod enhances DNA repair as mechanism for its activity, nucleotide excision genes were studied bone marrow-derived cells. enhanced expression xeroderma pigmentosum (XP) A other (quantitative real-time PCR analysis) resulted an increased nuclear localization enzyme XPA. This was dependent on MyD88, cells from...
Radiomics has been applied to predict recurrence in several disease sites, but current approaches are typically restricted analyzing tumor features, neglecting nontumor information the rest of body. The purpose this work was develop and validate a model incorporating radiomics, including whole-body treatment outcomes patients with previously untreated locoregionally advanced cervical cancer. Methods: We analyzed 127 cancer treated definitively chemoradiotherapy intracavitary brachytherapy....
Pelvic exenterations are extensive surgical procedures for locally advanced or recurrent malignancies of the pelvis. However, this is often at cost significant morbidity due to perioperative pain, which has been poorly studied.This study aims review pain management in patients undergoing pelvic exenteration.This a retrospective exenteration between January 2013 and December 2014. Data were gathered from medical records prospectively maintained database.This was conducted single quaternary...
Existing methods often fail to recognize the conversions for biological roles of pairs genes and microRNAs (miRNAs) between tumor normal samples. We have developed a novel cluster scoring method identify messenger RNA (mRNA) miRNA interaction clusters while considering samples jointly. Our has identified 54 significant 15 cancer types selected from The Cancer Genome Atlas project. also determined shared across and/or subtypes. In addition, we compared gene overlap lists in our liver...
e16098 Background: Renal cell carcinoma (RCC) is the most common kidney malignancy and eighth cancer overall, with more than 60,000 new cases nearly 15,000 deaths in United States each year. The majority of RCC asymptomatic detected incidentally on computed tomography (CT) scans performed for other indications. Multiple prior studies have highlighted potential a lesion to be missed or mischaracterized. Artificial intelligence (AI), mimicking human cognition by computers, has promise...
Abstract Background. While multiple studies have demonstrated improved clinical outcomes in patients receiving concurrent chemotherapy and immunotherapy, synergy may be limited by the destructive effects of DNA-damaging on non-cancer cells, including key constituents anti-tumor immunity (e.g. mature T cells). Furthermore, when first-line fails, subsequent lines produce lower response rates. Thus, new approaches that eradicate cancer cells while preserving immune required to more efficiently...
Abstract Background. Neutrophil elastase (ELANE) - a neutrophil-derived serine protease kills wide range of cancer cells without harming non-cancer through unique killing program involving histone H1 and the death domain CD95. Although ELANE attenuates tumor growth induces anti-tumor immunity following intratumoral delivery (Cui et al., Cell, 2021), systemic is stymied by presence inhibitors in blood (eg. alpha-1-antitrypsin (A1AT) which rapidly inhibit its enzymatic activity essential for...
<h3>Background</h3> Prostate cancer is the second most common and leading cause of death in men. There are currently limited treatment options for metastatic prostate with poor prognosis, due to immune-cold tumor microenvironment (TME) not responding ICI therapies even high frequency tumor-associated macrophages (TAMs). E7766, as a macrocycle-bridged STING agonist constant activity variants, generates robust anti-tumor immune responses through production proinflammatory cytokines...
<h3>Background</h3> Immunogenic cell death (ICD) inducers are an emerging therapeutic modality that kill cancer cells to activate anti-tumor immunity through antigen liberation and presentation. While this dual mechanism of action has strong potential, cytotoxicity immune cells, as observed with ICD-inducing chemotherapies, hampered current approaches. We previously showed N17350, a neutrophil elastase-inspired serine protease, leverages novel cancer-selective killing pathway<sup>1</sup>...
Although there are many studies on the characteristics of miRNA-mRNA interactions using miRNA and mRNA sequencing data, complexity change correlation coefficients expression values pairs between tumor normal samples is still not resolved, this hinders potential clinical applications. There an urgent need to develop innovative methodologies tools that can characterize visualize functional consequences cancer risk gene while analyzing simultaneously.We developed bioinformatics tool for...
We construct a 1 x 2 matrix (a<sub>n</sub>, b<sub>n</sub>), whose entries are constructive real numbers. demonstrate that the values of minmax and maximin any can be algorithmically determined. In second part paper, we will show through proof by contradiction there does not exist program find coordinates or minmax. Together, these form fact every with has maxmin, but it is possible to given an arbitrary tells maxmin.
Merkel cell carcinoma (MCC) is an aggressive cutaneous malignancy with neuroendocrine origin. The rarity of the tumor and variable clinical presentation make diagnosis especially challenging. grows rapidly lymph node metastasis occurs early in disease course. etiology related to prior UV exposure, immunosuppression, polyomavirus infection. 2008 discovery infectious cause for majority cases sparked more research into pathogenesis possible therapeutic options. Although there has been recent...
Despite the progress we have recorded in last few years multilingual natural language processing, evaluation is typically limited to a small set of languages with available datasets which excludes large number low-resource languages. In this paper, created SIB-200 -- large-scale open-sourced benchmark dataset for topic classification 200 and dialects address lack Natural Language Understanding (NLU). For many covered SIB-200, first publicly NLU. The based on Flores-200 machine translation...