A5101796077- Neonatal Respiratory Health Research
- Atmospheric and Environmental Gas Dynamics
- Cancer, Hypoxia, and Metabolism
- Heat Transfer and Optimization
- Atmospheric Ozone and Climate
- Chronic Myeloid Leukemia Treatments
- Heat Transfer and Boiling Studies
- Cancer-related Molecular Pathways
- Cytokine Signaling Pathways and Interactions
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Research Studies
- Immune Response and Inflammation
- Atmospheric chemistry and aerosols
- Congenital Diaphragmatic Hernia Studies
- Spectroscopy and Laser Applications
- Immune Cell Function and Interaction
- Medical Imaging and Pathology Studies
- Lung Cancer Treatments and Mutations
- Eosinophilic Disorders and Syndromes
- Refrigeration and Air Conditioning Technologies
- Tracheal and airway disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Gastric Cancer Management and Outcomes
- Advanced Graph Neural Networks
- Liver Disease Diagnosis and Treatment
Shanghai Jiao Tong University
2016-2025
Shanghai Sixth People's Hospital
2018-2025
People’s Hospital of Rizhao
2024
First Affiliated Hospital of Chengdu Medical College
2024
West China Hospital of Sichuan University
2024
Northeastern University
2022-2024
Sichuan University
2024
Ministry of Agriculture and Rural Affairs
2022
Shihezi University
2022
South China Agricultural University
2022
Irreversible destruction of bronchi and alveoli can lead to multiple incurable lung diseases. Identifying stem/progenitor cells with regenerative capacity utilizing them reconstruct functional tissue is one the biggest hopes reverse damage cure such Here we showed that a rare population SOX9+ basal (BCs) located at airway epithelium rugae regenerate adult human lung. Human BCs be readily isolated by bronchoscopic brushing indefinitely expanded in feeder-free condition. Expanded give rise...
Abstract Recent evidence showed that limited activation of PI 3K/Akt pathway was critical for induction and function sustainment CD 4 + Foxp3 regulatory T cells (Tregs). However, the underlying mechanism remains largely unknown. In this study, we reported miR‐126 expressed in mouse human Tregs. Further study silencing using antisense oligonucleotides ( ASO ) could significantly reduce Tregs vitro . Furthermore, obviously expression on Tregs, which accompanied by decreased CTLA ‐4 GITR , as...
The aim of our study was to assess the effects mitochondrial coenzyme Q (MitoQ) on sepsis-induced acute lung injury (ALI) and investigate its possible mechanisms. cecal ligation puncture (CLP) method used establish a septic ALI model. Rats were randomly divided into Con group, CLP MitoQ + LY294002 group. survival rate rats recorded, curve plotted. Moreover, ratio wet/dry weight (W/D) in tissue measured. activity myeloperoxidase (MPO) measured by using MPO colorimetric assay kit. levels...
AbstractCpG-oligonucleotides (CpG-ODN), which induce signaling through Toll-like receptor 9 (TLR9), are widely used as adjuvants in therapy against cancer. However, tumor cells express functional TLR9 were recently reported and the immune effect of CpG ODN on remains unclear. Here we investigated direct effects human cell line 95D using flow cytometric analysis western blotting. We found strongly high expression cells. Stimulation with CpG-ODN induced significantly elevated secretion IL-1α...
Recent evidence shows that microRNAs (miRNAs) contribute to the biological effects of Toll-like receptor (TLR) signaling on various cells. Our previous data showed TLR9 could enhance growth and metastatic potential human lung cancer However, role miRNAs in tumor biology remains unknown. In this paper, we first report reduce intrinsic miR-7 expression Furthermore, overexpression can significantly inhibit signaling–enhanced cells vitro vivo. Notably, identify phosphoinositide-3-kinase,...
MicroRNAs (miRNAs) have been shown as an important regulator in the pathologies of acute lung injury (ALI). However, potential effect miRNA-based therapeutic studies ALI remains poorly understood. We assessed antisense oligonucleotides (ASOs) against miR-155 on development using a murine model. found that ASO treatment could enhance recovery evidenced by accelerated body weight back, reduced level bronchoalveolar lavage (BAL) protein and proinflammatory cytokines, number BAL cells. Adoptive...
Melanoma, a highly aggressive skin cancer, is characterized by its strong metastatic potential and resistance to standard treatments. Recent cancer research has emphasized the significance of exosomes, type extracellular vesicle particle, in mediating cell-to-cell communication driving tumor progression. Melanoma-derived exosomes contribute metastasis facilitating immune evasion, modulating microenvironment, inducing epithelial-to-mesenchymal transition. The exosomal cargos, including...
Osteosarcoma (OS) is the most common human primary malignant bone tumor in children and young adults with poor prognosis because of their high metastatic potential. Identification key factors that could regulate aggressive biologic behavior OS, particularly respect to metastasis, would be necessary if significant improvements therapeutic outcome are occur. In this study, we carefully evaluated potential role IL-17A/IL-17RA interaction metastasis OS. We found serum IL-17A was higher OS...
Our recent evidence showed that prior expansion of CCR6 + Foxp3 regulatory T cells (Tregs) was important for their dominant enrichment in tumor tissue, which closely related to poor prognosis breast cancer patients. However, the underlying regulation mechanism Tregs situ remains largely unknown. In this study, we reported miR‐21 highly expressed tissues from a murine model. And silencing could significantly reduce proliferation vitro . Adoptive cell‐transfer assay further alter mass and...
Cancer stem-like cells (CSCs) are critically involved in cancer metastasis and chemoresistance, acting as one major obstacle clinical practice. While accumulating studies have implicated the metabolic reprogramming of CSCs, mitochondrial dynamics such remain poorly understood. Here we pinpointed OPA1hi with fusion a feature human lung licensing their properties. Specifically, CSCs exerted enhanced lipogenesis, inducing OPA1 expression via transcription factor SAM Pointed Domain containing...
Abstract. The increase in greenhouse gas concentrations, particularly CO2, has significant implications for global climate patterns and various aspects of human life. Spaceborne remote sensing satellites play a crucial role high-resolution monitoring atmospheric CO2. However, the next generation is expected to face challenges, terms computational efficiency CO2 retrieval analysis. To address these this study focuses on improving speed retrieving column-averaged dry-air mole fraction carbon...
Introduction Patients with clinically significant portal hypertension (CSPH) are recommended to be treated non-selective beta-blockers (ie, carvedilol) prevent the first hepatic decompensation event by renewing Baveno VII consensus. CSPH is defined venous pressure gradient (HVPG)≥10 mm Hg; however, HVPG measurement not widely adopted due its invasiveness. Liver stiffness (LS)≥25 kPa can used as a surrogate of HVPG≥10 Hg rule in 90% positive predicting value majority aetiologies patients. A...
Abstract Background Development of a deep learning method to identify Barrett's esophagus (BE) scopes in endoscopic images. Methods 443 images from 187 patients BE were included this study. The gastroesophageal junction (GEJ) and squamous-columnar (SCJ) manually annotated by experts. Fully convolutional neural networks (FCN) developed automatically the trained evaluated two separate image sets. performance segmentation was intersection over union (IOU). Results proved be satisfying automated...