A5055959674- Pituitary Gland Disorders and Treatments
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Glioma Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Meningioma and schwannoma management
- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Fetal and Pediatric Neurological Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Microbial metabolism and enzyme function
- Traumatic Brain Injury Research
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Radiomics and Machine Learning in Medical Imaging
- Hippo pathway signaling and YAP/TAZ
- Liver Disease Diagnosis and Treatment
- Ion Transport and Channel Regulation
- Endoplasmic Reticulum Stress and Disease
- Ion channel regulation and function
- Medical Imaging Techniques and Applications
- Heme Oxygenase-1 and Carbon Monoxide
- Lung Cancer Treatments and Mutations
- Tryptophan and brain disorders
Zunyi Medical University
2021-2025
The First Affiliated Hospital, Sun Yat-sen University
2007-2025
Sun Yat-sen University
2007-2025
Duke University
2025
Peking University Cancer Hospital
2025
Henan Provincial Eye Hospital
2025
Henan Provincial People's Hospital
2025
Zhengzhou University
2025
Henan Academy of Sciences
2025
Peking University
2025
Alterations of gut microbiota have been implicated in multiple diseases including cancer. However, the spectrum lung cancer remains largely unknown. Here we profiled composition a discovery cohort containing 42 early-stage patients and 65 healthy individuals through 16S ribosomal RNA (rRNA) gene sequencing analysis. We found that displayed significant shift contrast to populations. To identify optimal signature for noninvasive diagnosis purpose, took advantage Support-Vector Machine (SVM)...
Lineage transition in adenocarcinoma (ADC) and squamous cell carcinoma (SCC) of non-small lung cancer, as implicated by clinical observation mixed ADC SCC pathologies adenosquamous carcinoma, remains a fundamental yet unsolved question. Here we provide vivo evidence showing the transdifferentiation cancer from to mice: Lkb1-deficient progressively transdifferentiates into SCC, via pathologically mAd-SCC intermediate. We find that reduction lysyl oxidase (Lox) decreases collagen disposition...
Significance Tumor suppressor genes (TSGs) play important roles in lung cancer initiation, progression, and even metastasis. Here, we take advantage of the clustered regularly interspaced short palindromic repeats/Cas9-mediated screening vivo technique to identify multiple tumor contributing malignant progression. Using genetically engineered mouse models, further confirm tumor-suppressive role epigenetic regulator UTX provide therapeutic implications for UTX-deficient tumors. Thus, our work...
Pituitary neuroendocrine tumor (PitNET) is one of the most common intracranial tumors with variable recurrence rate. Currently, prediction unsatisfying and can be improved by understanding cellular origins differentiation status. Here, to comprehensively reveal origin PitNET, we perform comparative analysis single-cell RNA sequencing data from 3 anterior pituitary glands 21 PitNETs. We identify distinct genes representing major subtypes well poorly differentiated PitNETs in each lineage. To...
Abstract Lkb1 deficiency confers the Kras -mutant lung cancer with strong plasticity and potential for adeno-to-squamous transdifferentiation (AST). However, it remains largely unknown how dynamically regulates AST. Using classical AST mouse model ( LSL-G12D/+ ;Lkb1 flox/flox , KL ), we here comprehensively analyze temporal transcriptomic dynamics of tumors at different stages by dynamic network biomarker (DNB) identify tipping point which Wnt signaling is abruptly suppressed excessive...
Lactate is a byproduct of glycolysis, and before the Warburg effect was revealed (in which glucose can be fermented in presence oxygen to produce lactate) it considered metabolic waste product. At present, lactate not only recognized as substrate that provides energy, but also signaling molecule regulates cellular functions under pathophysiological conditions. Lactylation, post‑translational modification, involved development various diseases, including inflammation tumors. Liver disease...
In an attempt to allow for acquisition of oocyte cytoplasmic maturation, PDE3 specific inhibitor, cilostamide and adenylate cyclase activator, forskolin were used extend pre-maturation culture immature human oocytes.Cumulus-oocyte complexes retrieved from unstimulated ovaries continuously cultured under 20 microM or 50 forskolin, alone in combination 6, 12, 24 48 h, respectively. Levels intercellular gap junction communication (GJC) maturational status examined at these designated time...
Abstract The serine/threonine kinase LKB1 is a well-characterized tumor suppressor that governs diverse cellular processes, including growth, polarity, and metabolism. Somatic-inactivating mutations in are observed about 15% to 30% of non–small cell lung cancers (NSCLC). inactivation confers adenocarcinomas (ADC) with malignant features remain refractory therapeutic intervention. YAP activation has been linked deficiency, but the role ADC formation progression uncertain. In this study, we...
Metastasis is the dominant cause of patient death in small-cell lung cancer (SCLC), and a better understanding molecular mechanisms underlying SCLC metastasis may potentially improve clinical treatment. Through genome-scale screening for key regulators mouse Rb1-/- Trp53-/- using pooled CRISPR/Cas9 library, we identified Cullin5 (CUL5) suppressor cytokine signaling 3 (SOCS3), two components Cullin-RING E3 ubiquitin ligase complex, as top candidates. Mechanistically, deficiency CUL5 or SOCS3...
Glioblastoma (GBM) may arise from astrocytes through a multistep process involving progressive accumulation of mutations. We explored whether GBM-derived extracellular vesicles (EVs) facilitate neoplastic transformation and malignant growth astrocytes. utilized conditioned media (CM) cultured glioma cells, its sequential filtration, diverse cell-based assays, RNA sequencing, metabolic assays to compare the effects EV-containing EV-depleted CM. GBM EVs facilitated pre-transformed but not...
Astrocytes and microglia play an orchestrated role following spinal cord injury; however, the molecular mechanisms through which regulate astrocytes after injury are not yet fully understood. Herein, were pharmacologically depleted effects on astrocytic response examined. We further explored potential involving signal transducers activators of transcription 3 (STAT3) pathway. For in vivo experiments, we constructed a contusion model C57BL/6 mice. To deplete microglia, all mice treated with...