A5028908031- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- RNA modifications and cancer
- Organic Chemistry Cycloaddition Reactions
- Free Radicals and Antioxidants
- Cancer Mechanisms and Therapy
- Hernia repair and management
- Cancer therapeutics and mechanisms
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Hippo pathway signaling and YAP/TAZ
- Chromatin Remodeling and Cancer
- Surgical site infection prevention
- ATP Synthase and ATPases Research
- Nitric Oxide and Endothelin Effects
- Pancreatic and Hepatic Oncology Research
- Acute Myeloid Leukemia Research
- HIV/AIDS drug development and treatment
- Neurological Disease Mechanisms and Treatments
- Esophageal and GI Pathology
- Hepatitis C virus research
- Acupuncture Treatment Research Studies
- Chemical Reaction Mechanisms
- Monoclonal and Polyclonal Antibodies Research
Center for Excellence in Molecular Cell Science
2013-2025
University of Chinese Academy of Sciences
2013-2025
Chinese Academy of Sciences
2012-2024
Shandong Provincial Hospital
2021-2024
Shandong First Medical University
2021-2024
Sun Yat-sen University
2024
State Key Laboratory of Chemical Engineering
2024
Children's Hospital of Chongqing Medical University
2023
Chongqing Medical University
2023
Nankai University
2022
Lung squamous cell carcinoma (LUSC) represents a major subtype of lung cancer with limited treatment options. KMT2D is one the most frequently mutated genes in LUSC (>20%), and yet its role oncogenesis remains unknown. Here, we identify as key regulator tumorigenesis wherein Kmt2d deletion transforms basal organoids to LUSC. loss increases activation receptor tyrosine kinases (RTKs), EGFR ERBB2, partly through reprogramming chromatin landscape repress expression protein phosphatases. These...
Drug resistance is a significant hindrance to effective cancer treatment. Although mechanisms of epidermal growth factor receptor (EGFR) mutant cells lethal EGFR tyrosine kinase inhibitors (TKI) treatment have been investigated intensively, how orchestrate adaptive response under sublethal drug challenge remains largely unknown. Here, we find that 2-h TKI elicits transient drug-tolerant state in lung cells. Continuous reinforces this tolerance and eventually establishes long-term resistance....
Metastasis is the dominant cause of patient death in small-cell lung cancer (SCLC), and a better understanding molecular mechanisms underlying SCLC metastasis may potentially improve clinical treatment. Through genome-scale screening for key regulators mouse Rb1-/- Trp53-/- using pooled CRISPR/Cas9 library, we identified Cullin5 (CUL5) suppressor cytokine signaling 3 (SOCS3), two components Cullin-RING E3 ubiquitin ligase complex, as top candidates. Mechanistically, deficiency CUL5 or SOCS3...
Metastasis is the major cause for high mortality of lung cancer with underlying mechanisms poorly understood. The scaffolding protein neural precursor cell expressed, developmentally down-regulated 9 (NEDD9) has been identified as a pro-metastasis gene in several types cancers including melanoma and breast cancer. However, exact role related mechanism NEDD9 regulating metastasis still remain largely unknown. Here, we demonstrate that knockdown significantly inhibits migration, invasion cells...
<b><i>Introduction:</i></b> Cadonilimab (AK104) is an innovative human programmed cell death-1 (PD-1)/cytotoxic T lymphocyte antigen-4 (CTLA-4) bispecific antibody. Compared with the combination therapy of PD-1 and CTLA-4 blockers, less cellular toxicity cadonilimab was significantly manifested. As one characteristic adverse effects cadonilimab, infusion-related reactions (IRRs) represent fever, chills, rash, decreased blood pressure, other symptoms....
Small-cell lung cancer (SCLC) is a recalcitrant characterized by high metastasis. However, the exact cell type contributing to metastasis remains elusive. Using Rb1L/L/Trp53L/L mouse model, we identify NCAMhiCD44lo/- subpopulation as SCLC metastasizing (SMC), which progressively transitioned from non-metastasizing NCAMloCD44hi (non-SMC). Integrative chromatin accessibility and gene expression profiling studies reveal important role of SWI/SNF complex, knockout its central component, Brg1,...