A5103102687- Mesenchymal stem cell research
- Pancreatic function and diabetes
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Gold and Silver Nanoparticles Synthesis and Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Immune cells in cancer
- Bone Tissue Engineering Materials
- Autophagy in Disease and Therapy
- 3D Printing in Biomedical Research
- Osteoarthritis Treatment and Mechanisms
- Diabetes and associated disorders
- Advanced biosensing and bioanalysis techniques
- Photodynamic Therapy Research Studies
- Nanocluster Synthesis and Applications
- Diet and metabolism studies
- Diabetic Foot Ulcer Assessment and Management
- Cancer-related molecular mechanisms research
- Supramolecular Self-Assembly in Materials
- Graphene and Nanomaterials Applications
- Advanced Glycation End Products research
- Hepatitis B Virus Studies
- Family Caregiving in Mental Illness
Tongji University
2007-2025
Chinese PLA General Hospital
2015-2025
Anhui University of Finance and Economics
2025
University of California, Davis
2024
People's Liberation Army No. 150 Hospital
2021-2024
Chinese People's Liberation Army
2022-2024
Harbin Medical University
2016-2022
Fourth Affiliated Hospital of Harbin Medical University
2018-2022
Beijing Chao-Yang Hospital
2022
PLA 306 Hospital
2022
A highly efficient drug vector for photodynamic therapy (PDT) delivery was developed by synthesizing PEGylated gold nanoparticle conjugates, which act as a water-soluble and biocompatible "cage" that allows of hydrophobic to its site PDT action. The dynamics release in vitro two-phase solution system vivo cancer-bearing mice indicates the process is efficient, passive targeting prefers tumor site. With Au NP−Pc 4 time required has been greatly reduced less than 2 h, compared days free drug.
Efficient drug delivery to tumors is of ever-increasing importance. Single-visit diagnosis and treatment sessions are the goal future theranostics. In this work, a noncovalent PDT cancer drug-gold nanoparticle (Au NP) conjugate system performed rapid release deep penetration into within hours. The mechanism through Au NPs by passive accumulation was investigated via fluorescence imaging, elemental analysis, histological staining. pharmacokinetics conjugates over 7-day test period showed...
Infusion of mesenchymal stem cells (MSCs) has been shown to effectively lower blood glucose in diabetic individuals, but the mechanism involved could not be adequately explained by their potential role promoting islet regeneration. We therefore hypothesized that infused MSCs might also contribute amelioration insulin resistance peripheral target tissues. To test hypothesis, we induced a rat model high-fat diet/streptozotocin (STZ) administration, performed MSC infusion during early phase (7...
In this feature article, gold nanoparticle conjugates loaded with phthalocyanine-based PDT drugs are prepared and tested for delivery efficiency efficacy on HeLa cancer cells. It could be shown that the outcome strongly affected by bond links drug load to surface. Whereas labile amino adsorption Au surface allows efficient release into cells PDT, a covalent thiol leads of cell vesicles, no effect is observed. This work highlights importance carefully choosing interaction between molecules
Insulin resistance, a major characteristic of type 2 diabetes (T2D), is closely associated with adipose tissue macrophages (ATMs) that induce chronic low-grade inflammation. Recently, mesenchymal stem cells (MSCs) have been identified in alleviation insulin resistance. However, the underlying mechanism still remains elusive. Thus, we aimed to investigate whether effect MSCs on resistance was related phenotypes tissues T2D rats. In this study, human umbilical cord-derived (UC-MSCs) infusion...
Targeted drug delivery using epidermal growth factor peptide-targeted gold nanoparticles (EGFpep-Au NPs) is investigated as a novel approach for of photodynamic therapy (PDT) agents, specifically Pc 4, to cancer. In vitro studies PDT show that EGFpep-Au NP-Pc 4 twofold better at killing tumor cells than free after increasing localization in early endosomes. vivo targeting with improves accumulation fluorescence subcutaneous tumors by greater threefold compared untargeted Au NPs. and...
A photoprecursor Pc 227 is covalently bound onto gold nanoparticles (Au NPs) to produce the known photodynamic therapy (PDT) drug 4 upon 660 nm photoirradiation. The photochemical formation of photoproduct identified by spectroscopy, chromatography, and mass spectrometry its PDT efficacy equal when administered non‐covalently Au NPs, with added benefit improved covalent delivery targeted NIR‐triggered release from 227‐Au NP conjugate, while during transport attached quenched inactivated.
Abstract Background Long-term diabetes-associated complications are the major causes of morbidity and mortality in individuals with diabetes. These diabetic closely linked to immune system activation along chronic, non-resolving inflammation, but therapies directly reverse these still not available. Our previous study demonstrated that mesenchymal stem cells (MSCs) attenuated chronic inflammation type 2 diabetes mellitus (T2DM), resulting improved insulin sensitivity islet function....
Irreversible destruction of bronchi and alveoli can lead to multiple incurable lung diseases. Identifying stem/progenitor cells with regenerative capacity utilizing them reconstruct functional tissue is one the biggest hopes reverse damage cure such Here we showed that a rare population SOX9+ basal (BCs) located at airway epithelium rugae regenerate adult human lung. Human BCs be readily isolated by bronchoscopic brushing indefinitely expanded in feeder-free condition. Expanded give rise...
Abstract Progressive pancreatic β-cell dysfunction is recognized as a fundamental pathology of type 2 diabetes (T2D). Recently, mesenchymal stem cells (MSCs) have been identified in protection islets function T2D individuals. However, the underlying mechanisms remain elusive. It widely accepted that closely related to improper accumulation macrophages islets, and series reports suggest MSCs possess great immunomodulatory properties by which they could elicit into an anti-inflammatory M2...
Abstract Background To determine the efficacy and safety of umbilical cord-derived mesenchymal stem cells (UC-MSCs) in Chinese adults with type 2 diabetes mellitus (T2DM). Methods In this single-center, double-blinded, randomized, placebo-controlled phase II trial, 91 patients were randomly assigned to receive intravenous infusion UC-MSCs ( n = 45) or placebo 46) three times 4-week intervals followed up for 48 weeks from October 2015 December 2018. The primary endpoint was percentage...
Osteochondral regeneration involves the highly challenging and complex reconstruction of cartilage subchondral bone. Silicon (Si) ions play a crucial role in bone development. Current research on Si mainly focuses repair, by using silicate bioceramics with ion compositions. However, it is unclear whether have important effect regeneration. Developing scaffold that solely releases to simultaneously promote repair stimulate critically important. Diatomite (DE) natural diatomaceous sediment can...
Background The current high rate of employee turnover has become a key factor affecting organizational stability and core competitiveness, which requires leaders to work with higher sense responsibility. Although several studies have confirmed that responsible leadership (RL) negatively affects employees’ intention, the specific mechanism this effect not been fully elucidated. Objective On basis discrepancy model psychological contract violation (PCV) substitutes for theory, study aims...
Electromigration of nanoparticles (NPs) is relevant to many technological and biological applications. We correlate the experimentally observed electromigration Au NPs with a closed-form theoretical model that furnishes key NP characteristics, including previously unknown values core ζ-potential, PEG-corona permeability, particle-hydrogel friction coefficient. More generally, theory new understanding in complex environments, establishing robust predictive guide design characterization...
Inorganic nanoparticles with unique physical properties have been explored as nanomedicines for brain tumor treatment.However, the clinical applications of inorganic formulations are often hindered by biological barriers and failure to be bioeliminated.The size nanoparticle is an essential design parameter which plays a significant role affect targeting biodistribution.Here, we report feasible approach assembly gold into ~80 nm nanospheres drug delivery platform enhanced retention in tumors...
Abstract Chronic hyperglycemia causes a progressive decrease of β -cell function and mass in type 2 diabetic patients. Growing evidence suggests that augment autophagy may be an effective approach to protect cells against various extra-/intracellular stimuli. In this study, we thus investigated whether bone marrow-derived mesenchymal stem (BM-MSCs) could ameliorate chronic high glucose (HG)-induced injury through modulation autophagy. Prolonged exposure HG decreased cell viability, increased...
Nonalcoholic fatty liver disease (NAFLD) is increasingly common among patients with type 2 diabetes mellitus (T2DM). The two conditions can act synergistically to produce adverse outcomes. However, the therapeutic options for NAFLD and T2DM are currently limited. Human umbilical cord-derived mesenchymal stem cells (UC-MSCs) have shown potential hepatic disorders such as cirrhosis fulminant failure. present study aimed at investigating effect of human UC-MSCs on a mouse model T2DM,...
Gelatin methacryloyl is a promising material in tissue engineering and has been widely studied three-dimensional bioprinting. Although gelatin possesses excellent biocompatibility tunable mechanical properties, its poor printability/processability hindered further applications. In this study, we report reversible physical crosslinking strategy for precise deposition of human chondrocyte-laden bioink at low concentration without any sacrificial by using extrusive The printing temperature was...
Developing a spatiotemporal-controlled platform with feasible synthesis and multifunctionality is highly desirable in the field of nanomedicine. Here, we present near-infrared (NIR)-light-triggered approach to control supramolecular assembly system for drug release achieve synergistic chemo-photothermal therapy cancer. A cucurbit[7]uril (CB[7]) stabilized gold nanostar (GNS) designed encapsulate anticancer camptothecin (CPT) via host-guest chemistry. Importantly, CB[7] behaves not only as...
Abstract Background Mesenchymal stem cells (MSCs) exert anti-diabetic effects and improve long-term complications via secretory that regulate macrophage polarisation attenuate inflammation. Enhancing the efficacy of MSCs needs to be explored further. The in vitro culture microenvironment influences profile MSCs. Therefore, we hypothesised a diabetic would promote secretion cytokines responsible for polarisation, further attenuating systemic inflammation enhancing on type 2 diabetes (T2D)...
The aim of this study was to investigate the relationship between SAF and CHD in general population China assess feasibility used as a predictor CHD. This nested within prospective REACTION (Cancer Risk Assessment Chinese Diabetic Population) which included total 5806 eligible participants from two communities located urban Beijing 2018. were measured using fluorescence detector (DM Scan). endpoint determined by face-to-face clinical survey. Pearson's correlation analysis, linear regression...