A5080367078- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Mesenchymal stem cell research
- Immune cells in cancer
- Extracellular vesicles in disease
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Inflammasome and immune disorders
- Diabetic Foot Ulcer Assessment and Management
- Adrenal and Paraganglionic Tumors
- Pancreatitis Pathology and Treatment
- Hormonal Regulation and Hypertension
- Pancreatic and Hepatic Oncology Research
- Metabolism, Diabetes, and Cancer
- Hydrogen's biological and therapeutic effects
- Diet and metabolism studies
- Diabetes Management and Research
- Cardiovascular Health and Disease Prevention
- Liver Disease and Transplantation
- Alcohol Consumption and Health Effects
- Congenital Diaphragmatic Hernia Studies
- Pituitary Gland Disorders and Treatments
- Nutritional Studies and Diet
- Blood Pressure and Hypertension Studies
Nankai University
2020-2024
People's Liberation Army No. 150 Hospital
2020-2024
Chinese People's Liberation Army
2020-2024
PLA 306 Hospital
2022
Beijing Tian Tan Hospital
2022
Beijing Friendship Hospital
2022
Chinese PLA General Hospital
2022
Beijing Chao-Yang Hospital
2022
ORCID
2021
Abstract The role of mesenchymal‐stem‐cell‐derived exosomes (MSCs‐Exo) in the regulation macrophage polarization has been recognized several diseases. There is emerging evidence that MSCs‐Exo partially prevent progression diabetic nephropathy (DN). This study aimed to investigate whether secreted by MSCs pre‐treated with a environment (Exo‐pre) have more pronounced protective effect against DN regulating balance macrophages. Exo‐pre and Exo‐Con were isolated from culture medium UC‐MSCs mimic...
Abstract Background Mesenchymal stem cells (MSCs) exert anti-diabetic effects and improve long-term complications via secretory that regulate macrophage polarisation attenuate inflammation. Enhancing the efficacy of MSCs needs to be explored further. The in vitro culture microenvironment influences profile MSCs. Therefore, we hypothesised a diabetic would promote secretion cytokines responsible for polarisation, further attenuating systemic inflammation enhancing on type 2 diabetes (T2D)...
Abstract Background Triglyceride glucose index (TyG index) was related with both type 2 diabetes (T2DM) and hypertension (HTN). Prospective studies linking the TyG to incidence of T2DM HTN comorbidity remain unclear. This study aimed explore longitudinal association between new-onset HTN. Methods 4,434 subjects (1249 males 3185 females) without initial were followed up for 7 years. conducted from November 2011 August 2018 in Gucheng, Laoshan Jinding communities Beijing. The during 7-year...
Infusion of mesenchymal stem cells (MSCs) induces polarization M2 macrophages in adipose tissue type 2 diabetes (T2D) mice. Studies have shown that were divided into four sub-phenotypes (M2a, M2b, M2c and M2d) with different functions, manuscripts also confirmed co-cultured MSCs not matched known phenotype macrophages. Therefore, our study explored the related gene expressions T2D mice with/without infusion.
BackgroundPrevious studies showed that MSCs could mitigate damage in the pancreas during acute pancreatitis (AP). However, mortality associated with AP was more often a result of persistent failure remote organs, rather than local damage, especially severe (SAP), and effect may vary depending on their origin.MethodsAn SAP model induced 8-week C57BL/6 J male mice by retrograde injection 5 % sodium taurocholate solution through bile duct. were divided into group, UC-MSCs BMSCs which treated...
Abstract Background Previous research has demonstrated that the spleen plays an important role in mesenchymal stem cell (MSC)-mediated alleviation of acute inflammation, as MSC infusion increases spleen-derived anti-inflammatory cytokine interleukin 10 (IL-10) levels. However, studies on splenic involvement MSC-induced protection against chronic inflammatory diseases are limited. Obesity is characterized by low-grade a key driver insulin resistance. This study aims to evaluate effects MSCs...
The Metabolic Score for Insulin Resistance (METS-IR) is a novel non-insulin-based metabolic index used as substitution marker of insulin resistance. However, whether METS-IR associated with the urinary albumin-to-creatinine ratio (UACR) not well known. Therefore, we explored associations between and UACR, compared discriminative ability its components elevated UACR.This study included 37,290 participants. was calculated follows: (Ln[2 × fasting blood glucose + triglyceride level] body mass...
The hypertriglyceridemic waist (HTGW) phenotype can predict cardiovascular disease (CVD) risk. Additionally, strong evidence indicates that elevated urinary albumin-creatinine ratio (UACR) is associated with increased prevalence of CVD. However, few studies have explored the association between HTGW and UACR.In this cross-sectional descriptive study, a total 40,674 subjects (28,562 women 12,112 men older than 40 years) were recruited from seven different geographic regional centres. was...
Mild autonomous cortisol secretion (MACS) presents with a marked female preponderance, but whether the sex difference in its distribution has any relevance to presentation and outcome of disease is unknown. The aim this study was therefore compare biochemical indices hypercortisolism impaired glucose metabolism between male patients MACS.We enrolled total 98 autonomous/possible our study, were collected compared patients. Logistic regression models used evaluate association...
Several studies have suggested that nonalcoholic fatty liver disease (NAFLD) is associated with cardiovascular (CVD). The excretion of low-level albuminuria (LLA) elevates as the prevalence CVD increases. However, few explored association between NAFLD and LLA.This cross-sectional study included 31 147 Chinese adults (7664 men 23 483 women). "normal" level determined by urinary albumin to creatinine ratio (UACR) was below 30 mg/g. LLA defined a higher within range (5.54 mg/g < LLA≤29.9...
Abstract BackgroundThe metabolic score for insulin resistance (METS-IR) is a novel noninsulin-based index used as substitution marker of resistance. However, whether METS-IR associated with the urinary albumin–creatinine ratio (UACR) not well known. Therefore, we explored associations between and UACR compared discriminative ability its components elevated UACR. MethodsThis study included 37,290 subjects. was calculated follows: (Ln [2 × fasting blood glucose (FBG) + triglyceride level (TG 0...
Abstract Background Triglyceride glucose index (TyG index) was related with both type 2 diabetes (T2DM) and hypertension (HTN). Prospective studies linking TyG to incidence of T2DM HTN comorbidity remains unclear. The aim this study explore the longitudinal association between new-onset HTN. Methods 4,434 subjects (1249 males 3185 females) without initial were followed up for 7 years. during 7-year follow-up identified as endpoint. divided into four quartiles: < 25% level, 25–50% 50–75% ≥...
Abstract Background Mesenchymal stem cells (MSCs) exert anti-diabetic effects and improve long-term complications via secretory that regulate macrophage polarisation attenuate inflammation. Enhancing the efficacy of MSCs needs to be explored further. The in vitro culture microenvironment influences profile MSCs. Therefore, we hypothesised a diabetic would promote secretion cytokines responsible for polarisation, further attenuating systemic inflammation enhancing on type 2 diabetes (T2D)...
Abstract Background : The metabolic score for insulin resistance (METS-IR) is a novel noninsulin-based index used as substitution marker of and cardiovascular disease evaluation. However, whether METS-IR associated with the urinary albumin–creatinine ratio (UACR) not well known. Therefore, we explored age- sex-related associations between UACR compared discriminative ability its components elevated UACR. Methods This study included 37,290 subjects from REACTION (Risk Evaluation cAncers in...