Kang Chen

ORCID: 0000-0003-0745-7946
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About
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Research Areas
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Pituitary Gland Disorders and Treatments
  • Ferroptosis and cancer prognosis
  • Cancer Mechanisms and Therapy
  • Liver Disease Diagnosis and Treatment
  • Adrenal and Paraganglionic Tumors
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Radiomics and Machine Learning in Medical Imaging
  • Pancreatic and Hepatic Oncology Research
  • ECG Monitoring and Analysis
  • Soft tissue tumor case studies
  • Renal cell carcinoma treatment
  • Neurofibromatosis and Schwannoma Cases
  • Growth Hormone and Insulin-like Growth Factors
  • Epilepsy research and treatment
  • Sarcoma Diagnosis and Treatment
  • Gastric Cancer Management and Outcomes
  • Metastasis and carcinoma case studies
  • Spine and Intervertebral Disc Pathology
  • Medical Imaging and Analysis
  • Cancer, Lipids, and Metabolism
  • Kidney Stones and Urolithiasis Treatments
  • Cancer-related molecular mechanisms research
  • Neurological Disease Mechanisms and Treatments
  • Osteoarthritis Treatment and Mechanisms

Guangxi Medical University
2020-2025

Zigong First People's Hospital
2024-2025

Chinese PLA General Hospital
2015-2025

Guiyang Medical University
2025

Affiliated Hospital of Guizhou Medical University
2025

Guangxi University
2025

Ruijin Hospital
2023-2024

Hunan Normal University
2022-2024

Army Medical University
2012-2024

Southwest Hospital
2014-2024

Febrile seizures (FSs) constitute the most prevalent seizure type during childhood. Whether prolonged FSs alter limbic excitability, leading to spontaneous (temporal lobe epilepsy) adulthood, has been controversial. Recent data indicate that, in immature rat model, induce transient structural changes of some hippocampal pyramidal neurons and long-term functional circuitry. However, whether these neuroanatomical electrophysiological promote excitability lead epilepsy remained unknown. By...

10.1002/1531-8249(200003)47:3<336::aid-ana9>3.0.co;2-w article EN Annals of Neurology 2000-03-01

Abstract Ru‐based nanomaterials are promising alternatives to Pt electrocatalysts for green hydrogen energy generation, and crystal phase engineering holds the key unlocking their catalytic potential new heights. However, controllable regulation on Ru‐alloys remains a formidable challenge, unraveling phase‐related electrocatalytic performance is of great significance. Herein, RuNi nanoparticles successfully synthesized with an unconventional face‐centered cubic ( fcc ) via facile route....

10.1002/adfm.202406259 article EN Advanced Functional Materials 2024-05-21

We developed a computational model integrating clinical data and imaging features extracted from contrast-enhanced computed tomography (CECT) images, to predict lymph node (LN) metastasis in patients with pancreatic ductal adenocarcinoma (PDAC).This retrospective study included 159 PDAC (118 the primary cohort 41 validation cohort) who underwent preoperative examination between 2012 2015. All surgery status was determined. A total of 2041 radiomics were venous phase images cohort, optimal...

10.1186/s40644-020-0288-3 article EN cc-by Cancer Imaging 2020-01-30

Abstract Few studies reported the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infected patients with completely asymptomatic throughout disease course. We investigated epidemiological and clinical features of by SARS‐CoV‐2 without any symptoms. Patients confirmed infection were retrospectively recruited. The demographic characteristics, data, treatment, outcomes symptoms analyzed. Fifteen (4.4%) 342 did not develop symptom during course disease. median time from exposure to...

10.1002/jmv.25944 article EN Journal of Medical Virology 2020-04-29

With the widespread use of anti-androgen therapy, such as abiraterone and enzalutamide, incidence neuroendocrine prostate cancer (NEPC) is increasing. NEPC a lethal form (PCa), with median overall survival less than one year after diagnosis. In addition to common bone metastases seen in PCa, exhibits characteristics visceral metastases, notably liver metastasis, which serves an indicator poor prognosis clinically. Key factors driving plasticity PCa have been identified, yet underlying...

10.1016/j.canlet.2024.217068 article EN cc-by-nc Cancer Letters 2024-06-18

Abstract Objective Radiation therapy (RT) may increase the risk of second cancer. This study aimed to determine association between exposure radiotherapy for treatment thoracic cancer (TC) and subsequent secondary lung (SLC). Materials Methods The Surveillance, Epidemiology, End Results (SEER) database (from 1975 2015) was queried TC. Univariate Cox regression analyses multiple primary standardized incidence ratios (SIRs) were used assess SLC. Subgroup patients stratified by latency time...

10.1111/crj.13760 article EN cc-by The Clinical Respiratory Journal 2024-05-01

Combining local interventions with tyrosine kinase inhibitors (TKIs) plus anti-PD-1 antibodies in a triple therapy has demonstrated remarkable anti-tumor efficacy and facilitated conversion resection patients initially unresectable hepatocellular carcinoma (HCC). However, the long-term survival outcomes remain largely unexplored. This study focused on cohort of consecutive who underwent for HCC at authors' hospital between January 2020 December 2022. Specifically, exhibited positive response...

10.1038/s41598-025-88813-8 article EN cc-by-nc-nd Scientific Reports 2025-02-04

This study aimed to identify mutations in the human insulin receptor gene (INSR) and investigate their role pathogenesis of severe resistance syndrome. Sanger sequencing INSR was performed on a patient clinically suspected having type A syndrome admitted Department Endocrinology, First Medical Center Chinese PLA General Hospital. Upon identifying mutations, relevant exons were sequenced her first-degree relatives. Additionally, control groups consisting individuals with 2 diabetes those...

10.3760/cma.j.cn112138-20240915-00582 article EN PubMed 2025-03-01

Objective This study aimed to explore the differences in risk factors for mortality between T2N1M0 and T3N0M0 lobular breast cancer, investigate associated with non-lobular cancer mortality. Methods Data from 2,693 1,384 patients SEER database (2008–2018) were analyzed. The cancer-specific compared using Kaplan-Meier curve Log-rank test. Cox proportional hazards regression analysis was used determine Results total survival time showed a significant difference groups (p = 0.0011)....

10.3389/fphar.2025.1550081 article EN cc-by Frontiers in Pharmacology 2025-03-11

Osteoporotic vertebral compression fractures (OVCFs) have become a significant public health concern due to the high morbidity and limited efficacy of conservative treatment. Conventional unilateral percutaneous kyphoplasty (UPKP) is beset by technical limitations, including uneven distribution cement inherent risk leakage. Conversely, curved (PCKP) involves creation an accessible contralateral bone tunnel through auger, technique that, in theory, optimizes distribution. However, clinical...

10.1007/s00590-025-04241-4 article EN cc-by-nc-nd European Journal of Orthopaedic Surgery & Traumatology 2025-04-01

ABSTRACT Background Type 2 diabetes mellitus (T2DM) constitutes a significant risk factor for breast cancer (BC), with affected women exhibiting two‐ to three‐fold increased likelihood of developing BC. Furthermore, diagnosed both BC and T2DM tend experience poorer prognoses exhibit greater resistance various treatments compared their non‐diabetic counterparts. Consequently, elucidating the comorbidities associated is instrumental in enhancing diagnostic therapeutic strategies Methods A...

10.1002/cam4.70759 article EN cc-by Cancer Medicine 2025-04-01

Abstract Contexts Bilateral inferior petrosal sinus sampling (BIPSS) can differentiate Cushing’s disease (CD) and ectopic adrenocorticotropin (ACTH) syndrome (EAS). The traditional cutoff of to peripheral (IPS:P) ACTH gradient was 2 before stimulation 3 after stimulation, which yielded unsatisfactory sensitivity in some studies. Objectives To determine the optimal BIPSS or desmopressin evaluate necessity stimulation. Design Setting Single-center retrospective study (2011–2018) along with...

10.1210/clinem/dgz194 article EN The Journal of Clinical Endocrinology & Metabolism 2019-11-23

Bilateral inferior petrosal sinus sampling (BIPSS) is useful for differential diagnosis of adult Cushing's disease (CD) but may not be so reliable in pediatric cases. The purpose this study was to evaluate the sensitivity BIPSS before and after desmopressin stimulation CD, explore related factors false-negative results meanings lateralization. We retrospectively analyzed 16 CD patients who underwent 17 procedures from 2006 2017. diagnosed if (IPS) peripheral adrenocorticotropic hormone...

10.1007/s12020-018-1779-x article EN cc-by Endocrine 2018-10-11

Hydatid disease is a severe and widespread human cestode infection, in children, the lung most commonly infected organ. In current practice, standard surgical procedure for removal of pulmonary hydatid cysts thoracotomy; therefore, we evaluated efficacy safety video-assisted thoracoscopic surgery (VATS) to treat pediatric disease. To our knowledge, this first large sample comparative study VATS thoracotomy study, retrospectively reviewed 44 (61.1 %) patients who underwent VATS, 28 (38.9...

10.1186/s13019-016-0525-9 article EN cc-by Journal of Cardiothoracic Surgery 2016-08-05
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