A5075002556- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
- Liver Disease and Transplantation
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Pancreatitis Pathology and Treatment
- Folate and B Vitamins Research
- Cancer, Lipids, and Metabolism
- Electronic Packaging and Soldering Technologies
- HIV/AIDS drug development and treatment
- Liver Diseases and Immunity
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- Trace Elements in Health
- Metal Forming Simulation Techniques
- Iron Metabolism and Disorders
- Plant Toxicity and Pharmacological Properties
- Child and Animal Learning Development
- Adipokines, Inflammation, and Metabolic Diseases
- Acute Kidney Injury Research
- Advanced Welding Techniques Analysis
- Viral Infections and Outbreaks Research
- RNA modifications and cancer
Changzhou Third People's Hospital
2016-2025
Xuzhou Medical College
2025
Nanjing Medical University
2023-2024
Guilin University of Electronic Technology
2022
Changzhou No.2 People's Hospital
2018-2020
Jiangsu University
2018
Affiliated Hospital of Jiangsu University
2018
Creative Research Enterprises (United States)
2018
Shanghai Jiao Tong University
2017
Infectious Diseases Institute
2011
Limited data are available for clinical characteristics of patients with coronavirus disease 2019 (COVID-19) outside Wuhan. This study aimed to describe the COVID-19 and identify risk factors severe illness in Jiangsu province, China. Clinical hospitalized were retrospectively collected 8 hospitals from cities findings described analyzed. By Feb 10, 2020, 202 enrolled. The median age was 44.0 years (interquartile range, 33.0-54.0). 55 (27.2%) had comorbidities. At onset illness, common...
Abstract We reported the clinical characteristics of a case series 10 patients with coronavirus disease 2019 (COVID‐19) aged from 1 year to 18 years. Seven had contact confirmed COVID‐19 family members before onset. Fever (4 [40.0%]) and cough (3 [30.0%]) were most common symptoms. No patient showed leucopenia lymphopenia on admission. Pneumonia was observed in chest CT images 5 (50.0%) patients. Five received antiviral treatment. severe complications or developed illness our study. Our...
Previous studies reported that coronavirus disease 2019 (COVID-19) was likely to result in liver injury. However, few investigated injury patients with COVID-19 chronic diseases. We described the clinical features nonalcoholic fatty (NAFLD). Confirmed from hospitals 10 cities of Jiangsu Province, China, were retrospectively included between January 18, 2020, and February 26, 2020. The hepatic steatosis index (HSI) used defined NAFLD. A total 280 enrolled. Eighty-six (30.7%) diagnosed as...
This study aimed to observe the clinical characteristics of patients with coronavirus disease 2019 (COVID-19) overweight and obesity.Consecutive COVID-19 from 10 hospitals Jiangsu province, China, were enrolled.A total 297 included, 39.39% 13.47% had obesity, respectively. The proportions bilateral pneumonia (92.50% vs. 73.57%, P = 0.033) type 2 diabetes (17.50% 3.57%, 0.006) higher in obesity than lean patients. severe illness (12.82% 2.86%, (25.00% < 0.001) significantly More developed...
Abstract Few studies reported the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infected patients with completely asymptomatic throughout disease course. We investigated epidemiological and clinical features of by SARS‐CoV‐2 without any symptoms. Patients confirmed infection were retrospectively recruited. The demographic characteristics, data, treatment, outcomes symptoms analyzed. Fifteen (4.4%) 342 did not develop symptom during course disease. median time from exposure to...
The objective of this study was to investigate the association between sarcopenia and liver fibrosis in patients aged 18–59 years with metabolic dysfunction-associated steatotic disease (MASLD) assess potential as a risk factor for progression fibrosis. included 821 MASLD US cohort 3,405 Chinese cohort. Liver controlled attenuation parameters (CAP) stiffness measurements (LSM) were assessed by vibration-controlled transient elastography (VCTE) evaluate extent hepatic steatosis Sarcopenia...
The objective of this study was to validate the diagnostic accuracy acFibroMASH index in a population metabolic dysfunction-associated steatotic liver disease (MASLD) patients with at-risk steatohepatitis (MASH) and compare it other scoring systems. 394 biopsy-proven MASLD were retrospectively enrolled. divided into MASH (NAFLD activity score ≥ 4 significant fibrosis) group (n = 103) non-at-risk 291). performance compared that fibroScan-aspartate aminotransferase (FAST) noninvasive fibrosis...
Abstract Background & Aims Serum Golgi protein 73 ( GP 73) is a potential biomarker for fibrosis assessment. We aimed to develop an algorithm based on and liver stiffness LS ) further improvement of accuracy significant in patients with antiviral‐naïve chronic hepatitis B virus (HBV) infection. Methods Diagnostic evaluation development 73‐ was performed training cohort (n = 267) independent 133) validation. Results A stepwise increasing pattern serum observed across stages HBV...
Previous studies reported that coronavirus disease 2019 (COVID-19) was likely to result in liver injury. However, few the impacts of COVID-19 on function patients with chronic diseases. We aimed describe a case series hepatitis B virus (HBV) infection. Confirmed hospitalized from hospitals 10 cities Jiangsu province, China, were retrospectively included between 18 January 2020 and 26 February 2020. Demographic information, epidemiologic data, clinical features, treatment data extracted...
Serum hepatitis B virus RNA (HBV RNA) has been reported to be a surrogate marker of intrahepatic cccDNA during nucleos(t)ide analogs therapy. However, in HBeAg-positive patients treated with peg-interferon (peg-IFN), whether HBV is superior other markers reflecting profile still unclear. RNA, HBcrAg, DNA, and HBsAg were longitudinally assessed among 30 48-week peg-IFN treatment. Besides, was detected at baseline week 48 respectively. Then, the individual correlations between HBsAg,...
Abstract Background Health Related Quality of Life (HRQL) is a multi-dimensional construct that can comprehensively evaluate the patient’s health status, including physical, emotional, mental and social well-being. In this study, we aimed to impact non-alcoholic fatty liver disease (NAFLD) on HRQL in Chinese population. Methods national multicenter cross-sectional survey, patients with NAFLD were enrolled. Chronic Liver Disease Questionnaire (CLDQ)-NAFLD was used qualify HRQL. Univariate...
Purpose: The identification of significant fibrosis is critical for predicting the prognosis non-alcoholic fatty liver disease (NAFLD). This study aimed to compare predictive value chitinase-3-like protein 1 (CHl3L1) and other non-invasive biomarkers, as well establish a novel diagnostic model assessing risk in NAFLD. Patients Methods: A total 71 patients with confirmed NAFLD based on biopsy were included this study. Serum CHI3L1 levels assessment measures determined. aspartate...
Background: Limited data are available for clinical characteristics of patients with coronavirus disease 2019 (COVID-19) outside Wuhan. This study aimed to describe the COVID-19 and identify risk factors severe illness in Jiangsu province, China. Methods: Clinical hospitalized were retrospectively collected ten hospitals from nine cities findings described analyzed. Findings: By Feb 10, 2020, 221 enrolled. The median age was 45.0 years (interquartile range, 33.5–56.0). 60 (27.1%) had...
Nonalcoholic fatty liver disease (NAFLD) is a growing global public health concern and becoming the leading cause of worldwide. The estimated prevalence NAFLD ∼25% depending on country assessment method used to establish diagnosis. Meta-analyses suggest that highest in Middle East (31.8%) South America (30.4%), lowest Africa (13.5%). In United States, between 75 100 million individuals were have NAFLD. This important associated with increased incidence liver-related deaths, hepatocarcinoma,...
Abstract Background Convalescent plasma (CP) transfusion was reported to be effective in treating critically ill patients with COVID-19, and hydroxychloroquine could potently inhibit SARS-CoV-2 vitro. Herein, we a case receiving combination therapy CP for the first time. Case presentation Laboratory findings showed high lactic acid level (2.1 mmol/L) C-reactive protein (CRP, 48.8 mg/L), low white blood cell count (1.96 × 10 9 /L) 65-year-old Chinese man, who diagnosed severe COVID-19....
Acute-on-chronic liver failure (ACLF) is a syndrome with high short-term mortality, and predicting the prognosis challenging. This study aimed to compare performance of neutrophil gelatinase-associated lipocalin (NGAL) cystatin C (CysC) in 90-day mortality patients hepatitis B virus (HBV)-associated ACLF (HBV-ACLF).
Aim Pyrrolizidine alkaloids-induced hepatic sinusoidal obstruction syndrome(PA-HSOS) has been reported to have high mortality. We evaluated the efficacy and safety of anticoagulation therapy for patients with PA-HSOS. Methods collected clinical data on 249 PA-HSOS from January 2012 December 2017 at four tertiary care hospitals. Among them, 151 received therapy, 98 supportive treatment. The outcomes were analyzed using Fine Gray competing risk analysis method Cox regression model. Results...
Abstract Background There is still little knowledge about the association of liver fibrosis with clinical outcomes COVID‐19 patients non‐alcoholic fatty disease (NAFLD). The aim study was to determine NAFLD score (NFS)–determined NAFLD. Methods diagnosed by Hepatic Steatosis Index (HSI) in absence other causes chronic diseases. NFS used evaluate severity fibrosis. Results A total 86 were included. median age 43.5 years, and 58.1% male. Thirty‐eight (44.2%) had advanced according NFS....