A5102998385- Gut microbiota and health
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Cancer, Hypoxia, and Metabolism
- Long-Term Effects of COVID-19
- Cancer Research and Treatments
- Hepatitis B Virus Studies
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Diet and metabolism studies
- Cancer Immunotherapy and Biomarkers
- RNA Research and Splicing
- Heat shock proteins research
- Circular RNAs in diseases
- Colorectal Cancer Surgical Treatments
- Bone Tumor Diagnosis and Treatments
- Wnt/β-catenin signaling in development and cancer
Yangzhou University
2018-2025
Xuzhou Medical College
2008-2025
Affiliated Hospital of Guizhou Medical University
2023
Nagasaki University
2020
Guangzhou Center for Disease Control and Prevention
2020
National Institute Of Hygiene And Epidemiology
2020
People's Hospital of Xinjiang Uygur Autonomous Region
2020
Shanghai Tenth People's Hospital
2016-2018
Tongji University
2016-2018
Shanghai Jiao Tong University
2014-2018
Limited data are available for clinical characteristics of patients with coronavirus disease 2019 (COVID-19) outside Wuhan. This study aimed to describe the COVID-19 and identify risk factors severe illness in Jiangsu province, China. Clinical hospitalized were retrospectively collected 8 hospitals from cities findings described analyzed. By Feb 10, 2020, 202 enrolled. The median age was 44.0 years (interquartile range, 33.0-54.0). 55 (27.2%) had comorbidities. At onset illness, common...
Abstract We report epidemiologic, laboratory, and clinical findings for 7 patients with 2019 novel coronavirus disease in a 2-family cluster. Our study confirms asymptomatic human-to-human transmission through close contacts familial hospital settings. These might also serve as practical reference diagnosis medical treatment.
Abstract: Colorectal cancer (CRC) is a common digestive malignancy and emerging studies have closely linked its initiation development with gut microbiota changes. Fusobacterium nucleatum ( Fn ) has been recently identified as pathogenic bacteria for CRC; however, prognostic significance patients poorly investigated less within late stage. Therefore, in this study, we made efforts to analyze level retrospective cohort of 280 stage III/IV CRC patients. We found that the was abnormally high...
Previous studies reported that coronavirus disease 2019 (COVID-19) was likely to result in liver injury. However, few investigated injury patients with COVID-19 chronic diseases. We described the clinical features nonalcoholic fatty (NAFLD). Confirmed from hospitals 10 cities of Jiangsu Province, China, were retrospectively included between January 18, 2020, and February 26, 2020. The hepatic steatosis index (HSI) used defined NAFLD. A total 280 enrolled. Eighty-six (30.7%) diagnosed as...
Recent studies have indicated that the epithelial-mesenchymal transition (EMT) is a key molecular mechanism involved in development of colorectal cancer (CRC). N-cadherin mesenchymal marker EMT and has been closely linked to several human malignancies. However, its role CRC remained elusive. In present study, qRT‑PCR western blot analysis N‑cadherin expression was higher tumor tissues than their adjacent normal tissues. Immunohistochemical evaluation E‑cadherin (an epithelial EMT),...
This study aimed to observe the clinical characteristics of patients with coronavirus disease 2019 (COVID-19) overweight and obesity.Consecutive COVID-19 from 10 hospitals Jiangsu province, China, were enrolled.A total 297 included, 39.39% 13.47% had obesity, respectively. The proportions bilateral pneumonia (92.50% vs. 73.57%, P = 0.033) type 2 diabetes (17.50% 3.57%, 0.006) higher in obesity than lean patients. severe illness (12.82% 2.86%, (25.00% < 0.001) significantly More developed...
Recent studies have demonstrated that the manipulation of gut microbiome represents a promising treatment for inflammatory bowel disease (IBD). We previously identified micro integral membrane protein (MIMP) as smallest domain surface layer from Lactobacillus Plantarum. However, therapeutic relevance MIMP in IBD remains unknown.We initially employed dextran sodium sulphate (DSS)-induced colitis model and evaluated effect on inflammation response, intestinal barrier microbiota using...
Gut microbiota and integrins are known to contribute colorectal cancer (CRC), but whether they interact has been unclear. Here, we provided evidence that Fusobacterium nucleatum upregulated integrin α5 (ITGA5) in CRC both human patients murine models. Knocking down ITGA5 cells weakened the ability of F. stimulate their malignant characteristics. increased intracellular Ca2+ concentration, which turn promoted interaction between E-cadherin Krüppel-like factor 4 (KLF4), resulting KLF4...
Because patients with colorectal cancer (CRC) are usually diagnosed at an advanced stage and current serum tumor markers have limited diagnostic efficacy, there is urgent need to identify reliable biomarkers. To better define the potential of microRNAs (miRNAs) for CRC, we performed a comprehensive evaluation reported circulating CRC miRNA markers. After systematic literature review, selected 30 candidate miRNAs used quantitative real-time polymerase chain reaction examine their expression...
Cell cycle regulatory pathway is a well-established mainly dependent on cyclin-dependent kinases (CDKs), which are regulated positively by cyclins and negatively kinase inhibitors(CKIs). Cyclin-dependent 2 associate protein 1(CDK2-AP1) specific negative for CDK2, important in the cancer cell cycle. However, function of CDK2-AP1 breast remains unclear. We designed therefore explored effects growth its chemo-sensitivity.Expression CDK2-AP1, CDK2 CyclinD1 209 cases pathological specimens using...
Although the cancer immunotherapy represents one of most promising strategies for treatment, PD-1/PD-L1 pathway, which involves a receptor-ligand interaction, can induced immunosuppression by disabling tumor-infiltrating lymphocytes (TILs). In present study, we coupled PD-L1 (Programmed cell death 1 ligand 1) recognizable peptide DPPA-1 to sequence CGKRK, namely tumor vasculature affinity peptide, form new molecule CD peptide. Thereafter, paclitaxel (PTX)-loaded PCL nanoparticles were...
Microtubule-actin cross-linking factor-1 (ACF7, or MACF1) regulates cytoskeletal focal adhesion dynamics and migration in various tissues. High fat diet (HFD) induces gut microbiota dysbiosis metabolic disorders, increases intestinal permeability inflammatory response. Here we investigated the synergistic effects of ACF7 conditional knockout (ACF7 cKO) HFD on metabolism phenotypes, barrier function mice. cKO control (ACF7fl/fl) mice (8-week-old) were fed with either chow HFD, for 16 weeks....
Cancer stem cells have recently been identified as a key driving factor for tumor metastasis and chemoresistance. CD117 is well-established cancer cell marker, but its clinical significance in epithelial ovarian (EOC) remains controversial. Therefore, we aimed to identify correlations between expression features outcomes EOC patients this meta-analysis.A literature search was performed the PubMed, Cochrane Library, Web of Science, EMBASE, OVID databases eligible studies. Correlations...
Colorectal cancer (CRC) is a commonly diagnosed digestive malignancy worldwide. Ras-related protein 1A (RAP1A) member of the Ras superfamily small GTPases and has been recently identified as novel oncoprotein in several human malignancies. However, its specific role CRC remains unclear.In this study, we firstly analyzed expression clinical significance retrospective cohort 144 patients. Then, cellular assays vitro vivo were performed to clarify biological cells. Finally, microarray analysis...
Chemotherapy of glioma is always hampered by the unsatisfactory tumor accumulation drugs, which most noticeable obstacle limited drug permeability from vessels into inner. In present study, we developed a novel nanocarrier for delivery doxorubicin to brain tumor. Such system was mainly composed homing peptide and DOX-loaded PLA nanoparticles (AP1-NP-DOX). CRKRLDRNC peptide, named as AP1, newly affinity could specifically binds interleukin-4 receptor (IL-4R), highly expressing on both cells...
// Dapeng Wu 1, * , Liguo Liu 2, Xuebing Yan 3, Chunyan Wang 1 Yaling Kun Han Shuchen Lin Zhihua Gan and Daliu Min Department of Oncology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China 2 General Surgery, 3 Tenth Tongji School Medicine, These authors have contributed equally to this work Correspondence to: Min, email: mindaliu1969@163.com Keywords: PTN, osteosarcoma, chemoresistance, doxorubicin, β-catenin Received: December 02,...
// Xuebing Yan 1, * , Zezhi Shan Leilei 1 Qingchao Zhu Liguo Liu Bing Xu 2 Sihong Zhiming Jin Yuping Gao 3 Department of General Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China Medicine, Soochow Suzhou, Jiangsu Province, Center for Reproductive Xinhua Hospital, School These authors have contributed equally this work Correspondence to: Jin, e-mail: jzmgyp@aliyun.com Gao, pingyugao@aliyun.com Keywords: colorectal cancer, ZFX, tumor growth,...