A5101897923- Acute Myeloid Leukemia Research
- SARS-CoV-2 detection and testing
- Cancer Genomics and Diagnostics
- Acute Lymphoblastic Leukemia research
- Biosensors and Analytical Detection
- MicroRNA in disease regulation
- Chronic Myeloid Leukemia Treatments
- Head and Neck Cancer Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Cells and Metastasis
- Toxin Mechanisms and Immunotoxins
- Advanced biosensing and bioanalysis techniques
- Multiple Myeloma Research and Treatments
- Cancer Mechanisms and Therapy
- PI3K/AKT/mTOR signaling in cancer
- T-cell and B-cell Immunology
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Polyamine Metabolism and Applications
- NF-κB Signaling Pathways
- Inflammatory Myopathies and Dermatomyositis
- Kruppel-like factors research
Changhai Hospital
2025
Second Military Medical University
2025
University of Colorado Anschutz Medical Campus
2016-2024
Nanjing Medical University
2011-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Jiangsu Cancer Hospital
2022
Nantong University
2020-2022
Affiliated Hospital of Nantong University
2020-2022
Shanghai Tenth People's Hospital
2022
Tongji University
2022
Head and neck squamous cell carcinoma (HNSCC) patients have a poor prognosis, with invasion metastasis as major causes of mortality. The phosphatidylinositol 3-kinase (PI3K) pathway regulates wide range cellular processes crucial for tumorigenesis, PIK3CA amplification mutation are among the most common genetic alterations in human HNSCC. Compared well-documented roles PI3K growth survival, tumor not been well delineated. We generated genetically engineered mouse model (PIK3CA-GEMM) which...
Gut microbiota and integrins are known to contribute colorectal cancer (CRC), but whether they interact has been unclear. Here, we provided evidence that Fusobacterium nucleatum upregulated integrin α5 (ITGA5) in CRC both human patients murine models. Knocking down ITGA5 cells weakened the ability of F. stimulate their malignant characteristics. increased intracellular Ca2+ concentration, which turn promoted interaction between E-cadherin Krüppel-like factor 4 (KLF4), resulting KLF4...
Polymyositis (PM) and dermatomyositis (DM) are idiopathic inflammatory myopathies. Genetic variability in human leukocyte antigen (HLA) genes plays an important role the pathogenesis of PM DM. However, few studies on subject Chinese populations have been reported thus far. We studied influence HLA polymorphisms DM susceptibility by analyzing HLA-DRB1, HLA-DQA1, HLA-DQB1 alleles 71 adult patients, 20 113 controls a Han population. A positive association was found between HLA-DQA1*0104 (p =...
Recurrence and metastasis are the major causes of mortality in head neck squamous cell carcinoma (HNSCC). It is suggested that cancer stem cells (CSCs) play pivotal roles recurrence metastasis. Thus, a greater understanding mechanisms CSC regulation may provide opportunities to develop novel therapies for improving survival by controlling or Here, we report overexpression gene encoding catalytic subunit PI3K ( PIK3CA ), most frequently amplified oncogene HNSCC, promotes...
MicroRNAs (miRNAs) play important roles in the initiation and progression of cancers. The purpose present study was to evaluate use serum miRNA biomarkers early diagnosis breast cancer.The expression levels miR-9-5p, miR-17-5p, miR-148a-3p were analyzed by quantitative reverse transcription-polymerase chain reaction 49 patients with newly diagnosed cancer healthy controls. associations between clinicopathological parameters also analyzed. Regression analysis sensitivity specificity analyses...
Primary testicular diffuse large B-cell lymphoma (PT-DLBCL) is a rare and aggressive form of mature commonly found in elder males, but its genetic features are poorly understood. In this study, we had performed target-sequencing 360 lymphoma-related genes on 76 PT-DLBCL patients with median age 65 (33-89). Our data provide comprehensive understanding the landscape mutations small subset PT-DLBCL.
To identify aberrant promoter methylation of genomic loci encoding microRNA (mgmiR) in head and neck squamous cell carcinoma (HNSCC) to evaluate a biomarker panel mgmiRs improve the diagnostic accuracy HNSCC tissues saliva. Methylation regions mgmiR candidates was initially screened using control lines further selected by quantitative methylation-specific PCR (qMS-PCR). We then examined seven for validation an expanded cohort including 189 92 non-HNSCC controls. Saliva from 86 pre-treatment...
The cytokine receptor-like factor 2 (CRLF2) gene plays an important role in early B-cell development. Aberrations CRLF2 activate the JAK-STAT signaling pathway that contributes to acute lymphoblastic leukemia (B-ALL). prognostic significance of overexpression and P2RY8-CRLF2 fusion various B-ALL risk subgroups has not been well established. Two hundred seventy-one patients with newly diagnosed childhood were enrolled from a Chinese population. prevalence overexpression, CRLF2-P2RY8 fusion,...
The prevalence and clinical relevance of KIT mutations in childhood core-binding factor (CBF) acute myeloid leukemia (AML) have not been well characterized. In this study, a total 212 children with de novo AML were enrolled from Chinese population 50 (23.5%) the patients deemed CBF-AML. identified 30% CBF-AML cohort. clustered exon 17 8, exons 8 correlated shorter overall survival (OS) (5-year OS: 30.0 ± 14.5% vs. 73.0 8.5%, p = .007) event-free (EFS) EFS: .003). Multivariate analysis...
This study aimed to investigate whether annexin A7 (ANXA7) could promote the cell cycle, proliferation and adhesion-mediated drug resistance (CAM-DR) of multiple myeloma (MM) cells by up-regulating division cycle 5-like (CDC5L).As a result, ANXA7 expression was increased in serum MM patients CDC5L also lines.ANXA7 overexpression promoted U266 RPMI8226 cells.The nuclear antigen (PCNA), KI67, cyclin dependent kinase 1 (CDK1) cyclinB1 transfected consistent with changes cycle.In co-culture...
Transforming growth factor-β1 (TGF-β1) mediates the development of glomerulosclerosis by stimulating mesangial cell production extracellular matrix (ECM) proteins. TGF-β1 and several ECM genes are regulated promoter O-tetradecanoylphorbol 13-acetate-responsive elements (TREs) that transactivated activator protein-1 (AP-1) transcription factor complex. AP-1-TRE interactions redox changes. Recently, peroxisome proliferator-activated receptors (PPARs) were shown to negatively regulate families....
The structural maintenance of chromosome (SMC) gene family, including 6 proteins, is involved in a wide range biological functions different human cancers. Nevertheless, there little research on the expression patterns, potential and prognostic value SMC genes hepatocellular carcinoma (HCC). Based publicly available databases integrative bioinformatics analysis, we tried to determine predicting risk developing HCC.The copy number variations data family members were obtained from TCGA (The...
Terbinafine inhibits the proliferation of many types cancer cells, but underlying mechanism remains to be determined.By computer simulation, we found that kinase suppressor Ras 1 (KSR1) is a possible target terbinafine.Treatment human oral squamous cell carcinoma (OSCC) KB cells with either terbinafine or siRNA knockdown KSR1 reduced and induced apoptosis, which was accompanied by suppression Raf-MEK-ERK pathway.In vivo, expression significantly associated clinical staging OSCC smoking habit...
Salivary gland tumor (SGT) is a rare type, which exhibits broad-spectrum phenotypic, biological, and clinical heterogeneity. Currently, the molecular mechanisms that cause SGT pathogenesis remain poorly understood. A lack of animal models faithfully recapitulate naturally occurring process human SGTs has hampered research progress on this field. In report, we developed an inducible keratin 5-driven conditional knockout mouse model to delete gene(s) interest in murine salivary upon local...
Single nucleotide polymorphisms (SNPs) may influence the disease course and outcome of hematologic neoplasms. SNP rs2454206 is common in TET2 gene, which plays a role epigenetic regulation myelopoiesis. Few investigations examined acute myeloid leukemia (AML) none those studies was performed Chinese populations. Here, we report prevalence clinical relevance 254 patients with childhood AML. Our data demonstrate that rs2454206AG/GG associated improved overall survival event-free AML...
Substantial advances in our understanding of the developmental and functional relationship between regulatory T cells (T(regs)) helper 17 (T(H)17) their potential clinical applications have been made. In response to these breakthroughs, second international conference entitled "China Tregs/Th17 2010 Shanghai Conference," held Shanghai, China, was dedicated this topic. Various types T(regs) T(H)17 cells, as well relevant cytokines, were discussed. Here, we summarize some findings shared at...
Epidermal growth factor receptor (EGFR) is often overexpressed in head and neck squamous cell carcinoma (HNSCC) represents a top candidate for targeted HNSCC therapy. However, the clinical effectiveness of current Food Drug Administration (FDA)-approved drugs targeting EGFR moderate, overall survival rate patients remains low. Therefore, more effective treatments are urgently needed. In this study, we generated novel diphtheria toxin-based bivalent human epidermal fusion toxin (bi-EGF-IT) to...
Reports of the efficacy induction chemotherapy (IC) combined with concurrent chemoradiotherapy (CCRT) on locoregionally advanced nasopharyngeal carcinoma (NPC) are scarce. This study aimed to compare clinical outcomes GP (gemcitabine plus cisplatin) regimen and TPF (taxane, cisplatin 5-FU) CCRT in patients NPC.This retrospectively analyzed 827 NPC who received IC People's Hospital Rizhao, China from January 2006 June 2012. The propensity score method was used reduce effects observed...