A5101807468- Functional Brain Connectivity Studies
- Immune Cell Function and Interaction
- Ovarian cancer diagnosis and treatment
- Immunotherapy and Immune Responses
- Liver Disease and Transplantation
- Endometrial and Cervical Cancer Treatments
- Thyroid Cancer Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Attention Deficit Hyperactivity Disorder
- Liver Disease Diagnosis and Treatment
- Endometriosis Research and Treatment
- Pancreatitis Pathology and Treatment
- Phagocytosis and Immune Regulation
- Hepatitis B Virus Studies
- Liver physiology and pathology
- Cancer-related molecular mechanisms research
- Autism Spectrum Disorder Research
- Alzheimer's disease research and treatments
- Renal Diseases and Glomerulopathies
- Metabolism, Diabetes, and Cancer
- Vasculitis and related conditions
- Cholinesterase and Neurodegenerative Diseases
- Immune Response and Inflammation
- Ion Transport and Channel Regulation
- Nuclear Receptors and Signaling
First Affiliated Hospital of Jinan University
2024-2025
Jinan University
2024-2025
Guangdong Provincial People's Hospital
2017-2025
Capital Medical University
2022-2024
Beijing Hospital of Traditional Chinese Medicine
2022-2024
Tianjin Medical University
2023
Tianjin Central Hospital of Gynecology Obstetrics
2023
Central South University
2015-2019
First Affiliated Hospital of Gannan Medical University
2019
Xiangya Hospital Central South University
2017-2019
Antibody-dependent cellular phagocytosis (ADCP) is an immune biological process and plays a role in the clearance of tumor cells response to checkpoint inhibitors. However, effects ADCP on stomach adenocarcinoma (STAD) remain unclear. Clinical genomic data were extracted from multiple datasets. The ADCP-related signature was established using Cox least absolute shrinkage selection operator regression. Expression C5a receptor also known as complement component 5a 1 adjacent-normal tissues...
To explore the therapeutic effects and mechanisms of interleukin 10 gene-modified bone marrow-derived dendritic cells (DC-IL10) on liver fibrosis.In vitro, BMDCs were transfected with lentiviral-interleukin 10-GFP (LV-IL10-GFP) at MOI 1 : 40. Then, phenotype (MHCII, CD80, CD86) allo-stimulatory ability DC-IL10 identified by flow cytometry, levels IL-10 IL-12 (p70) secreted into culture supernatants quantified ELISA. In vivo, was injected mice CCl4-induced fibrosis through tail vein....
Aims . Acute-on-chronic liver failure (ACLF) and acute (ALF) are similar in many respects during their exacerbation; however, ACLF generally has a poorer prognosis. We aimed to investigate the role dynamic changes of regulatory T cell (Treg) helper 17 (Th17) proportions progress. Methods All rats were classified into two groups randomly: group ALF (control group). The rat model was preestablished by intraperitoneal injection carbon tetrachloride for 2 months. Then injury induced combined...
MicroRNAs (miRNAs) play important roles in the initiation and progression of cancers. The purpose present study was to evaluate use serum miRNA biomarkers early diagnosis breast cancer.The expression levels miR-9-5p, miR-17-5p, miR-148a-3p were analyzed by quantitative reverse transcription-polymerase chain reaction 49 patients with newly diagnosed cancer healthy controls. associations between clinicopathological parameters also analyzed. Regression analysis sensitivity specificity analyses...
The objective of this study is to explore the effect melatonin on endoplasmic reticulum stress in acute pancreatitis (AP) and molecular mechanism.Acute was induced vivo Sprague-Dawley rats by retrograde injection 5% taurocholate into biliopancreatic duct vitro treating AR42J cells with cerulein (10 nmol/L) plus lipopolysaccharide (LPS) mg/L). were treated (50 mg/kg 0.5, 1, 2 mmol/L cells) 30 minutes before AP induced. After 9 hours, rat pancreas tissue collected for Western blot, reverse...
Bufadienolides are a type of cardiotonic steroids isolated from the skin and parotid venom glands toad Bufo bufo gargarizans Cantor, exhibit wide-spectrum anticancer activities. However, effects mechanisms bufadienolides on esophageal squamous cell carcinoma (ESCC) cells remain unknown. In present study, activities two bufadienolides, bufotalin bufalin, were examined in vitro vivo. The results demonstrated that bufalin effectively inhibited viability ESCC cells, with half-maximal inhibitory...
It is well known that AMP-activated protein kinase (AMPK) a key factor affecting the development of type 2 diabetes mellitus (T2DM). The single nucleotide polymorphism (SNP) rs2746342 in AMPK alpha subunit gene (PRKAA2) has been found to be associated with susceptibility T2DM Chinese Han population. present study further investigates association PRKAA2 genotypes and its complication, diabetic nephropathy.The 406 patients 214 controls from population were determined regard SNPs rs10789038,...
Aim: To investigate the association between SNPs in DNA damage response pathways and toxicities following 131I radiotherapy of differentiated thyroid cancer (DTC). Materials & methods: We identified 22 functional genes pathways. MassArray was used to sequence SNP genotypes 203 DTC patients. Hardy–Weinberg equilibrium associations two alleles each toxicity reactions were evaluated using χ2 analysis. Results: Ataxia-telangiectasia mutated (ATM) rs620815 T-allele carriers at increased risk...
To the EditorWe read with interest recent article in this journal by Yao et al. [1] on cryptococcal meningitis (CM). In their study, response rate to voriconazole was more favourable than t...
Aim: To investigate the clinical roles of LINC00152 and SNHG12 in papillary thyroid carcinoma (PTC). Methods:LINC00152 expression was sought analysis gene omnibus, The Cancer Genome Atlas GEPIA datasets. Tumor adjacent normal tissues were collected from 97 PTC 44 benign nodules patients. evaluated by quantitative real-time polymerase chain reaction. association between level clinicopathologic characteristics analyzed χ2 test. Receiver operating characteristic curves plotted to evaluate...
Abstract Endotoxin tolerance (ET) is suggested to attenuate the severity of acute liver failure (ALF) in mice, possibly through both innate and adaptive immunity. However, involvement regulatory dendritic cells (DCregs) ET has not been fully elucidated. In this study, their effect on ALF mice was investigated. Splenic DCregs from ET-exposed (ET-DCregs) showed lower expression levels CD40, CD80, MHC-II markers stronger inhibition allogenic T regulation IL-10 IL-12 secretion than splenic...
Metformin is a classical oral antidiabetic drug, often recommended to be the first-choice treatment of type 2 diabetes mellitus (T2DM). Based on previous research STK11 and diabetes, we aimed investigate distributive characteristic rs2075604 polymorphism potential influence metformin efficacy among Chinese T2DM patients. There was no significant difference between patients (G = 64.8%, T 35.2%) healthy subjects 62.7%, 37.2%) in genotype allele frequencies. After 12 weeks treatment, 62 were...
A previous genome-wide association study showed that hTERT rs10069690 and rs2736100 polymorphisms were associated with thyroid cancer risk. This further investigated the between increased risk clinicopathologic characteristics for Papillary Thyroid Carcinoma (PTC) or in a Chinese female population. The genotypes of 276 PTC patients 345 healthy subjects determined regard to SNPs rs2736100. these was by logistic regression. We found significant difference (Odds Ratio (OR) = 1.515; P 0.005),...
Numerous neuroimaging studies conducted have shown functional and structural brain alterations in patients with ASD. We a whole-brain voxel-wise meta-analysis to summarize previous inconsistent results by using Seed-based d Mapping software. In the present multimodal meta-analysis, specific regions were found, which provide new insights into quest for neuroimaging-based marker
Motivation: Numerous neuroimaging studies have reported that Alzheimer's disease and preclinical AD been linked to alterations in the amplitude of low-frequency fluctuation /fractional ALFF cortical thickness some brain areas. Goal(s): However, findings inconsistent correlation with transcriptional profile neurotransmitter systems remain largely unknown. Approach: We conducted a meta-analysis identify multimodal differences ALFF/fALFF CT patients AD, using Seed-based d Mapping Permutation...