A5100749506- Blood properties and coagulation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Epigenetics and DNA Methylation
- Pancreatitis Pathology and Treatment
- Metabolism, Diabetes, and Cancer
- Effects and risks of endocrine disrupting chemicals
- Protein Kinase Regulation and GTPase Signaling
- Ubiquitin and proteasome pathways
- Erythrocyte Function and Pathophysiology
- Neurological and metabolic disorders
- Retinal Diseases and Treatments
- Adipose Tissue and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Acute Kidney Injury Research
- Carcinogens and Genotoxicity Assessment
- Hemoglobin structure and function
- Retinal Imaging and Analysis
- Histone Deacetylase Inhibitors Research
- Diabetic Foot Ulcer Assessment and Management
- Pain Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Lipid metabolism and disorders
- Gallbladder and Bile Duct Disorders
- Vitamin C and Antioxidants Research
Southeast University
2024-2025
University of Georgia
2024
Beijing YouAn Hospital
2023
Capital Medical University
2023
Zhengzhou Central Hospital
2011-2021
Longgang Central Hospital
2017-2021
Chongqing Medical University
2017-2019
Brown University
2018
The Affiliated Yongchuan Hospital of Chongqing Medical University
2017
The Fourth People's Hospital
2011
Significance The interendothelial slit (IES) is the narrowest circulatory pathway in human spleen where aged and diseased red blood cells (RBCs) are filtered. We use a two-component RBC model to probe dynamics of healthy RBCs traversing IES. Our simulations reveal that not only senses clears with abnormal shapes deformability but also alters geometries contain protein defects arising from hereditary disorders. framework presented here sufficiently general be extended elucidate...
Widespread exposure to organophosphorus flame retardants (OPFRs) has been observed in the general population. Emerging studies have revealed OPFRs possess endocrine-disturbing properties. The present study aims assess association between urinary metabolites of OPFRs, BMI, and serum lipid profiles. Data from National Health Nutrition Examination Survey (NHANES) 2017–2018 were obtained, with 1334 adults enrolled current study. Urinary concentrations bis (1-chloro-2-propyl) phosphate (BCIPP),...
Background: Humans are consistently and increasingly exposed to phthalate products, but the effect of combined exposure phthalates on myocardial injury remains largely unexplored. The present study aimed explore injury. Methods: A total 1237 male adults (aged ≥20) without coronary artery disease (CAD) from National Health Nutrition Examination Survey (NHANES) in 1999–2004 were included current study. Multiple linear regression, Bayesian kernel machine regression (BKMR), a weighted quantile...
It is well known that AMP-activated protein kinase (AMPK) a key factor affecting the development of type 2 diabetes mellitus (T2DM). The single nucleotide polymorphism (SNP) rs2746342 in AMPK alpha subunit gene (PRKAA2) has been found to be associated with susceptibility T2DM Chinese Han population. present study further investigates association PRKAA2 genotypes and its complication, diabetic nephropathy.The 406 patients 214 controls from population were determined regard SNPs rs10789038,...
Histone deacetylase 9 (HDAC9) is involved in a variety of malignant tumors, and leads to tumor development poor prognosis. However, the association between HDAC9 expression, prognosis clinicopathological features patients with pancreatic ductal adenocarcinoma (PDAC) remains unclear. The present study used reverse transcription‑quantitative PCR, western blotting immunohistochemistry detect expression level PDAC tumors cell lines. Kaplan‑Meier method Pearson's χ2 test were applied evaluate...
The survival rate of patients with pancreatic cancer is between 3 and 5%. neddylation pathway overactive in multiple types associated poor prognosis. In recent years, the process has become a popular research target for development novel therapies. However, activation level pathway, whether its targeting sensitizes cells to cisplatin treatment currently unclear. present study, using reverse transcription-quantitative PCR western blot analyses, was observed be overactivated at protein, but...
Diabetes mellitus (DM) is a hyperglycemia-related multifactorial condition with an elevated risk of microvascular and complications associated this disease. The current experimental study was to examine the antidiabetic activity streptozotocin (STZ)-induced adropin against diabetic rats by altering PI3K/Akt insulin signaling pathways. STZ (60 mg/kg) used for induction DM were divided into different groups received (20, 40 80 glibenclamide (10 till 28 days. Body weight, plasma insulin, blood...
To investigate the relationship between geometrical changes of retinal vessels and diabetic peripheral neuropathy (DPN), to determine effectiveness vascular geometry analysis vibration perception threshold (VPT) for DPN assessment. Type 2 diabetes patients (n = 242) were categorized by stage DPN. VPT fundus photography was performed obtain parameters. The risk factors correlation stages analyzed. efficiency geometric parameters obtained with as a diagnostic tool examined. Stages showed...
Metformin is a classical oral antidiabetic drug, often recommended to be the first-choice treatment of type 2 diabetes mellitus (T2DM). Based on previous research STK11 and diabetes, we aimed investigate distributive characteristic rs2075604 polymorphism potential influence metformin efficacy among Chinese T2DM patients. There was no significant difference between patients (G = 64.8%, T 35.2%) healthy subjects 62.7%, 37.2%) in genotype allele frequencies. After 12 weeks treatment, 62 were...
Background Acute kidney injury (AKI) is common after liver transplantation (LT). We developed a nomogram model to predict post-LT AKI.
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Potential use of sonographic TI‑RADS classification combined with circulating miRNA expression profiling in the diagnosis thyroid nodules was explored. Retrospective analysis performed on clinical data 121 patients nodules. The biopsy specimens obtained through ultrasound‑guided aspiration and blood were evaluated Zhengzhou Central Hospital Affiliated to University from June 2018 2019. In addition, specimen test results healthy volunteers (control group) who underwent physical examination...
Objective Through determined serum lipids of type 2 diabetes mellitus with gallstone, and to discuss the effect factors gallstone in diabetic patients. Methods All cases were divided into two groups: gallstone(tests group) without gallstone(control group).We defected levels lipids, glucose, insulin evaluating resistance index (HOMA-IR) high-risk Results The insulin, HOMA-IR, HDL-C, LDL-C, ApoA1 ApoB significant different groups (P<0.05). Conclusions There are relations between mellitus....
Objective To study the relationship between glycemic control and platelet parameters in newly diagnosed type 2 diabetic patients. Methods Ninety patients as diabetes 90 healthy people were enrolled into study. Their blood pressure, parameters, including platelets count (PLT), mean volume (MPV), distribution width (PDW), fasting glucose (FPG),HbA1c ,triglyceride ( TG ), total cholesterol TC high density lipoprotein (HDL-C low cholesterol(LDL-C) examined data analyzed. Results The level of...