A5039012798- Blood properties and coagulation
- Advancements in PLL and VCO Technologies
- Erythrocyte Function and Pathophysiology
- Radio Frequency Integrated Circuit Design
- Mobile Ad Hoc Networks
- Lattice Boltzmann Simulation Studies
- Photonic and Optical Devices
- Cooperative Communication and Network Coding
- Rheology and Fluid Dynamics Studies
- Analog and Mixed-Signal Circuit Design
- Microwave Engineering and Waveguides
- Semiconductor Lasers and Optical Devices
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Wireless Networks and Protocols
- Hemoglobinopathies and Related Disorders
- Optical Network Technologies
- Pancreatitis Pathology and Treatment
- VLSI and Analog Circuit Testing
- Opportunistic and Delay-Tolerant Networks
- Low-power high-performance VLSI design
- Platelet Disorders and Treatments
- Phagocytosis and Immune Regulation
- Recycling and utilization of industrial and municipal waste in materials production
- Acoustic Wave Resonator Technologies
- COVID-19 Clinical Research Studies
Broadcom (United States)
2015-2024
Brown University
2023-2024
Jilin University
2019-2023
Nanjing University of Aeronautics and Astronautics
2020
Zhejiang University
2020
Bahria University
2020
Broadcom (Israel)
2014-2017
Cornell University
2009-2012
Tsinghua University
2005-2007
In this paper we will present a low-phase-noise wide-tuning-range oscillator suitable for scaled CMOS processes. It switches between the two resonant modes of high-order LC resonator that consists identical tanks coupled by capacitor and transformer. The mode switching method does not add lossy to thus doubles frequency tuning range without degrading phase noise performance. Moreover, leads 3 dB lower than single tank, which provides way achieving low in process. Finally, novel using...
We will introduce a design of analog-to-digital converters (ADCs) based on digital delay lines. Instead voltage comparators, they convert the input into code by lines and are mainly built blocks. This makes it compatible with process scaling. Two structures proposed, tradeoffs in discussed. The effects jitter mismatch also studied. present two 4 bit, 1 GS/s prototypes 0.13 mum 65 nm CMOS processes, which show small area (0.015 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Hematocrit, defined as the volume percentage of red blood cells in blood, is an important indicator human health status, which demonstrates capability to deliver oxygen. It has been studied over many decades using vivo, vitro, and silico experiments, recent studies have shown that its major feature microvascular networks temporal-spatial heterogeneity. The present work a numerical study such heterogeneity, based on direct simulations cellular-scale flow complex networks. take into account...
Red blood cell (RBC) aging manifests through progressive changes in morphology, rigidity, and expression of membrane proteins. To maintain the quality circulating blood, splenic macrophages detect biochemical signals biophysical RBCs selectively clear them erythrophagocytosis. In sickle disease (SCD), display alterations affecting their interaction with macrophages, leading to aberrant phagocytosis that may cause life-threatening spleen sequestration crises. illuminate mechanistic control...
In this paper, we present a distributed dual-band LC oscillator suitable for low-phase-noise applications. It switches between the odd and even resonant modes of fourth-order resonator. contrast to other switched-resonator designs, used mode selection do not carry current, therefore, affect quality factor resonator, which leads low phase noise. Analysis shows it achieves same phase-noise figure-of-merit (FoM) as single-band that uses inductor active core. This was verified by prototype in...
At rates of 100Gb/s and above, CMOS DSP-based transceivers integrated with high-sampling-rate data converters are critical to realize the phase-sensitive modulation schemes based on coherent detection that essential metro long-haul networks [1]. To support dual-polarization QPSK format, quad low-power DACs ADCs needed precise phase alignment has be maintained between XI, XQ, YI, YQ channels, in order transmit extract information system, as shown Fig. 29.2.1. For transmission at 100Gb/s,...
This paper presents a distributed multi-phase oscillator based on left-handed LC-ring. In contrast to traditional designs that couple multiple LC-tanks through MOSFETs, it uses an LC-ring as single high-order resonator generates resonant signal. By avoiding coupling MOSFETs which deteriorate phase noise significantly, can synthesize phases while maintaining the same phase-noise figure-of-merit (FoM) single-stage LC oscillator. also provides systematic way of trading power for noise. The...
Blood plasma separation may be one of the most frequent operations in daily laboratory analysis so that a highly efficient could save time, cost, and labor for operators. A numerical technique is demonstrated this work to design microfluidic chip can separate 64% from blood with 100% purity. Simulations are carried out flow by hybrid method smoothed dissipative particle dynamics immersed boundary (SDPD-IBM). SDPD used model motion flow, while IBM handle interaction between cells plasma....
We sought to study the role of circulating cellular clusters (CCC) -such as leukocyte (CLCs), platelet-leukocyte aggregates (PLA), and platelet-erythrocyte (PEA)- in immunothrombotic state induced by COVID-19. Forty-six blood samples from 37 COVID-19 patients 12 healthy controls were analyzed with imaging flow cytometry. Patients had significantly higher levels PEAs (p value<0.001) PLAs value = 0.015) compared controls. Among patients, CLCs correlated thrombotic complications 0.016),...
Being the largest lymphatic organ in body, spleen also constantly controls quality of red blood cells (RBCs) circulation through its two major filtration components, namely interendothelial slits (IES) and pulp macrophages. In contrast to extensive studies understanding function IES, fewer works investigate how splenic macrophages retain aged diseased RBCs, i.e., RBCs sickle cell disease (SCD). Herein, we perform a computational study informed by companion experiments quantify dynamics...
A wireless ad-hoc network can be roughly considered as one consisting of a collection mobile nodes distributed in finite region, which adopts non-centralized and self-organized structure. In such networks, messages are transmitted, received forwarded geometrical region. addition, the transmission is highly dependent on locations nodes. As result, relationships between nodes, especially distance them fundamental importance. this paper, we propose space decomposition method to analyze...
Numerically reproducing the process of thrombus formation is highly desired for understanding its mechanism but still remains challenging due to polydisperse feature blood components and their multiple biochemical or biomechanical behaviors involved. We numerically implemented a simplified version from perspective biomechanics, using mesoscale particle-based method, smoothed dissipative particle dynamics-immersed boundary method. This covers adhesion aggregation platelets (PLTs), deformation...
Nonlinear LC lattices have shown promise for high-power high-frequency signal generation. Here we offer the first detailed study of frequency response these lattices, as well a method designed to find input excitation frequencies that result in intense harmonic The crux is locate regions space where spectral norm lattice matrix large. When fundamental (or one its multiples) located regions, intensified. These findings are supported by extensive numerical simulations and experimental...
This paper addresses Rayleigh fading networks, and in particular, wireless ad-hoc sensor networks over channels. First, we will model show how to map the channel upper layer parameters for cross-layer design. Based on developed network model, consider two scarce resources of namely energy medium, develop a way improve their efficiency. In first study energy-efficiency introduce new parameter, cost factor, as counterpart transport capacity transmission. The parameter be used design...
In this paper we introduce a novel Analog-to-Digital architecture for high speed applications that is compatible with digital CMOS and surpasses the issues traditional voltage conversion techniques. The quantization method based on delay-to-digital concept as means to quantize variable delay line. A 4 bit 1 GS/s ADC mW power consumption designed in 65 nm proposed architecture. new highly scalable technology because of its delay-line-based core, ADCs performance enhances further scaling...
In this paper, we present a low-phase-noise wide-tuning-range quadrature oscillator using an LC-ring resonator. It achieves low phase noise by employing passive coupling between multiple stages and at the same time it covers wide tuning range switching two resonant modes. Furthermore, problem of oscillation frequency uncertainty which is common issue in oscillators with modes addressed novel mode method. The proposed design verified four-stage prototype 65nm CMOS process, 2.78GHz-5.00GHz FoM...
Abstract Being the largest lymphatic organ in body, spleen also constantly controls quality of red blood cells (RBCs) circulation through its two major filtration components, namely interendothelial slits (IES) and pulp macrophages. In contrast to extensive studies understanding function IES, there are relatively fewer works on investigating how splenic macrophages retain aged diseased RBCs, i.e., RBCs sickle cell disease (SCD). Herein, we perform a computational study informed by companion...
In a wireless ad hoc network, messages are transmitted, received, and forwarded in finite geometrical region the transmission of is highly dependent on locations nodes. Therefore study relationship between nodes networks fundamental importance network architecture design performance evaluation. However, most previous works concentrated deployed two-dimensional or infinite three-dimensional space, while many cases space. this paper, we analyze characteristics space framework random graph...
Abstract The spleen constantly clears altered red blood cells (RBCs) from the circulation, tuning balance between RBC formation (erythropoiesis) and removal. retention elimination of RBCs occur predominantly in open circulation spleen, where must cross submicron-wide inter-endothelial slits (IES). Several experimental computational studies have illustrated role IES filtrating biomechanically morphologically based on a rigid wall assumption. However, these also reported that when size is...