A5001314156- Genetic Associations and Epidemiology
- Blood properties and coagulation
- Diet, Metabolism, and Disease
- Pancreatic and Hepatic Oncology Research
- Genetic and phenotypic traits in livestock
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Genetic Mapping and Diversity in Plants and Animals
- Erythrocyte Function and Pathophysiology
- Clusterin in disease pathology
- Lattice Boltzmann Simulation Studies
- Cardiovascular Function and Risk Factors
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Rheology and Fluid Dynamics Studies
- Pain Mechanisms and Treatments
- Immune cells in cancer
- Pancreatitis Pathology and Treatment
- Trace Elements in Health
- Atherosclerosis and Cardiovascular Diseases
- Lipid metabolism and disorders
- Inflammatory Biomarkers in Disease Prognosis
Huazhong University of Science and Technology
2022-2024
Jilin University
2023
We systematically investigated the bidirectional causality among HDL cholesterol (HDL-C), LDL (LDL-C), triglycerides (TGs), fasting insulin (FI), and glycated hemoglobin A1c (HbA1c) based on genome-wide association summary statistics of Europeans (n = 1,320,016 for lipids, 151,013 FI, 344,182 HbA1c). applied multivariable Mendelian randomization (MR) to account correlation different traits constructed a causal graph with 13 significant effects after adjusting multiple testing (P < 0.0025)....
Pancreatic cancer (PC) is the deadliest malignancy due to late diagnosis. Aberrant alterations in blood proteome might serve as biomarkers facilitate early detection of PC. We designed a nested case-control study incident PC based on prospective cohort 38,295 elderly Chinese participants with ∼5.7 years' follow-up. Forty matched pairs passed quality controls for proximity extension assay 1,463 serum proteins. With lenient threshold p < 0.005, we discovered regenerating family member 1A...
DNA methylation (DNAm) has been implicated in acute coronary syndrome (ACS), but the causality remains unclear cross-sectional studies. Here, we conduct a prospective epigenome-wide association study of incident ACS two Chinese cohorts (discovery: 751 nested case-control pairs; replication: 476 pairs). We identified and validated 26 differentially methylated positions (DMPs, false discovery rate [FDR] <0.05), including three mapped to known cardiovascular disease genes (PRKCZ, PRDM16,...
Abstract Background Although immune cells are involved in acute coronary syndrome (ACS), few studies have explored the association of incident ACS with relative cell proportions. We aimed to investigate proportions incidence and risk factors Dongfeng–Tongji cohort. Methods conducted analyses 38,295 subjects from first follow-up cohort, including DNA methylation profiles for 1570 individuals. The types were observed routine blood tests or estimated profiles. For both proportions, we tested...