A5101854110- Herpesvirus Infections and Treatments
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- RNA regulation and disease
- interferon and immune responses
- Hepatocellular Carcinoma Treatment and Prognosis
- Migraine and Headache Studies
- Animal Virus Infections Studies
- PI3K/AKT/mTOR signaling in cancer
- Osteoarthritis Treatment and Mechanisms
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Cerebrovascular and genetic disorders
- RNA Research and Splicing
- Monoclonal and Polyclonal Antibodies Research
- Pain Mechanisms and Treatments
- RNA Interference and Gene Delivery
- Genetic factors in colorectal cancer
- Liver physiology and pathology
- Healthcare and Venom Research
- Mycobacterium research and diagnosis
- Mitochondrial Function and Pathology
- Anesthesia and Pain Management
- Trigeminal Neuralgia and Treatments
- Blood transfusion and management
Nanjing Drum Tower Hospital
2015-2024
Peking University
2021-2024
Huaian First People’s Hospital
2024
Nanjing Medical University
2024
Nanjing University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Chinese Center For Disease Control and Prevention
2023
Massachusetts Institute of Technology
2019-2022
XinHua Hospital
2022
Shanghai University of Medicine and Health Sciences
2022
Pancreatic ductal adenocarcinoma (PDAC) has prominent extracellular matrix (ECM) that compromises treatments yet cannot be nonselectively disrupted without adverse consequences. ECM of PDAC, despite the recognition its importance, not been comprehensively studied in patients. In this study, we used quantitative mass spectrometry (MS)-based proteomics to characterize proteins normal pancreas and pancreatic intraepithelial neoplasia (PanIN)- PDAC-bearing from both human patients mouse genetic...
Infection of H5N1 influenza virus causes the highest mortality among all viruses. The mechanisms underlying such high viral pathogenicity are incompletely understood. Here, we report that encodes a microRNA-like small RNA, miR-HA-3p, which is processed from stem loop-containing RNA precursor by Argonaute 2, and plays role in enhancing cytokine production during infection. Mechanistic study shows miR-HA-3p targets poly(rC)-binding protein 2 (PCBP2) suppresses its expression. Consistent with...
Mesenchymal stem cell (MSC) migration determines the healing capacity of bone and is crucial in promoting regeneration. Migration MSCs highly dependent on degradation extracellular matrix by proteolytic enzymes. However, underlying mechanisms how enzymolysis paves way for to migrate from their niche defect area still not fully understood. Here, this study shows that high-temperature requirement A3 (HtrA3) overcomes physical barrier provides anchor points through collagen IV degradation,...
Mass spectrometry-based proteomic analyses performed on cartilage tissue extracts identified the serine protease HtrA1/PRSS11 as a major protein component of human articular cartilage, with elevated levels occurring in association osteoarthritis. Overexpression catalytically active form HtrA1, but not an site mutant (S328A), caused marked reduction proteoglycan content chondrocyte-seeded alginate cultures. Aggrecan degradation fragments were detected conditioned media from cultures...
Abstract Angiogenesis is crucial for successful bone defect repair. Co‐transplanting Bone Marrow Stromal Cells (BMSCs) and Endothelial (ECs) has shown promise vascular augmentation, but it face challenges in hostile tissue microenvironments, including poor cell survival limited efficacy. In this study, the mitochondria of human BMSCs are isolated transplanted to from same batch passage number (BMSCs mito ). The significantly boosted ability ‐ECs promote angiogenesis, as assessed by vitro...
Cytokine-induced memory-like natural killer (CIML NK) cells have been found to possess potent antitumor responses and induce complete remissions in patients with leukemia. However, the poor infiltration of transferred NK is a major obstacle developing adoptive cell immunotherapy for solid tumors. In our study, we explored potential using tumor-penetrating peptide iRGD deliver activated CIML deep into tumor tissues.After being briefly stimulated interleukin-12 (IL-12), IL-15, IL-18, were...
Abstract NO (nitric oxide)-mediated protein S -nitrosylation has been established as one major signaling mechanism underlying cancer initiation and development, but its roles in PDAC (pancreatic ductal adenocarcinoma) pathogenesis still remain largely unexplored. In this study, we identified 585 unique S- nitrosylation sites among 434 proteins patients PANC-1 cell line by a site-specific proteomics. Larger number of nitrosylated were tissues cells than adjacent non-cancerous tissues. These...
Abstract Confining cytokine exposure to the tumors would greatly enhance cancer immunotherapy safety and efficacy. Immunocytokines, cytokines fused tumor-targeting antibodies, have been developed with this intention, but without significant clinical success date. A critical limitation is uptake by receptor-expressing cells in blood, that decreases dose at tumor engenders toxicity. Small-format immunocytokines, constructed antibody fragments, are hypothesized improve specificity due rapid...
Cytokine-like protein 1 (CYTL1) expression is deliberately downregulated during the progression of multiple types cancers, especially breast cancer. However, metabolic characteristics cancer remain unclear. Here, we uncovered a risk cells harboring low CYTL1 expression, which metabolically controlled malignant progression. We performed metabolism comparison and revealed that with have highly suppressed transsulfuration activity driven by cystathionine β-synthase (CBS) contributes to de novo...
Purpose: To evaluate the psychosocial problems associated with strabismus and effects of corrective surgery in Chinese adolescents adults strabismus. Methods: Psychosocial function was assessed by using a self-response questionnaire administered before after surgery. The constructed based on previous studies clinical experience authors. Results: Many 56 included patients had some problems. Improvement self-confidence, self-esteem, relationships friends reported Conclusion: have low...
Abstract The vascular response following injury is pivotal for successful bone‐defect repair but constitutes a major hurdle in the field of regenerative medicine. Throughout this process, vessel stabilization crucial to provide an adequate nutrient supply and facilitate efficient waste removal. Therefore, study investigated whether promoting improves bone defect outcomes. findings show that insulin‐like growth factor‐binding protein (IGFBP) 7 exhibits novel biological function attenuating...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively kills tumor cells and augments chemotherapeutics in vivo. Here, we developed sTRAIL-iRGD, a recombinant protein consisting of sTRAIL fused to CRGDKGPDC, C-terminal end binding peptide with an integrin-binding arginine-glycine-aspartic acid (iRGD) motif. CRGDKGPDC is tumor-homing high penetration into tissue cells. We found that sTRAIL-iRGD internalized cultured gastric cancer localized both the mass vivo...
Postherpetic neuralgia (PHN) is commonly defined as pain persisting for at least 3 months after acute herpes zoster (AHZ) rash presentation. About one-tenth of all patients develop PHN. Circulating microRNAs (miRNAs) are promising biomarkers infectious diseases; however, there has been no relationship established between circulating miRNAs and PHN to date; the aim present investigation was elucidate this relationship. We compared serum levels miRNA in AHZ patients. Twenty-nine with 37...
Transcatheter arterial chemoembolization (TACE) is extensively used in the treatment of advanced hepatocellular carcinoma (HCC). However, efficacy TACE usually limited to secondary tumor hypoxia and hypoxia-related angiogenesis. In this study, poly(lactic-co-glycolic acid) (PLGA) microspheres (SOR-CAT-PLGA MSs) encapsulating sorafenib (SOR) catalase (CAT) were prepared by double-emulsion solvent diffusion method. Sorafenib inhibits angiogenesis, decomposes hydrogen peroxide (H2O2) generate...
Objective . Although intrathecal drug infusion has been commonly adopted for terminal cancer pain relief, its adverse effects have made many clinicians reluctant to employ it intractable pain. The objective of this study is compare the efficacy and security an continuous morphine ropivacaine versus alone Methods Thirty‐six patients received either a ( n = 19) or 17) using catheter through subcutaneous port. Numerical Rating Scale (NRS) scores Barthel Index were analyzed. Adverse...
Reactivated varicella-zoster virus (VZV), which lies latent in the dorsal root ganglions and cranial nerves before its reactivation, is capable of causing herpes zoster (HZ), but specific mechanism reactivation latency remains unknown. It was proposed that circulating microRNAs (miRNAs) body fluids could potentially indicate infection. However, connection between miRNAs has not been demonstrated. In this study, 41 HZ patients without superinfection were selected. The serum miRNA levels...
Postherpetic neuralgia (PHN) is the most common complication of acute herpes zoster. The treatment PHN remains a challenge for clinical pain management. Despite effectiveness anticonvulsants, antidepressants, and lidocaine patches in reducing PHN, many patients still face intractable disorders. In this randomized controlled study, we evaluated whether hydromorphone through intravenous patient-controlled analgesia (IV PCA) was effective relieving PHN. Patients with were randomly divided into...
To investigate the relationship between geometrical changes of retinal vessels and diabetic peripheral neuropathy (DPN), to determine effectiveness vascular geometry analysis vibration perception threshold (VPT) for DPN assessment. Type 2 diabetes patients (n = 242) were categorized by stage DPN. VPT fundus photography was performed obtain parameters. The risk factors correlation stages analyzed. efficiency geometric parameters obtained with as a diagnostic tool examined. Stages showed...
Abstract Angiogenesis is critical in tissue engineering and regenerative medicine. Once initiated, outgrowing capillaries are spearheaded by specialized endothelial cells (ECs) termed tip cells. Specification of from ECs during angiogenesis greatly influenced the surrounding extracellular matrix (ECM). However, crosstalk between ECM cell specification poorly understood. Here, this study shows that high‐temperature requirement A3 (HtrA3) protein deeply involved process. Specifically, HtrA3...