A5100411321- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Ovarian function and disorders
- T-cell and B-cell Immunology
- Reproductive System and Pregnancy
- Hepatocellular Carcinoma Treatment and Prognosis
- Endometriosis Research and Treatment
- Healthcare and Venom Research
- Cancer Immunotherapy and Biomarkers
- Reproductive Biology and Fertility
- Immune cells in cancer
- Immune Response and Inflammation
- Hematopoietic Stem Cell Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Acupuncture Treatment Research Studies
- Cancer Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- CAR-T cell therapy research
- Gastric Cancer Management and Outcomes
- Diabetes and associated disorders
- Pancreatic and Hepatic Oncology Research
- Hepatitis B Virus Studies
- Parasite Biology and Host Interactions
- Gynecological conditions and treatments
- Endometrial and Cervical Cancer Treatments
Nanjing Medical University
2011-2025
Tianjin First Center Hospital
2025
Tianjin Medical University
2025
Loma Linda University
2025
Nanjing Drum Tower Hospital
2012-2024
Nanjing University of Chinese Medicine
2013-2024
UNICEF East Asia and Pacific Regional Office
2018-2024
Continental (Germany)
2018-2024
Institute for Biomedicine
2018-2024
Jiangsu Cancer Hospital
2024
The American Society for Histocompatibility and Immunogenetics HLA common well-documented (CWD) catalog, CWD 2.0.0 catalog European Federation (EFI) have been published, which are useful improving the accuracy of genotyping in laboratories. Here, we studied Chinese catalog. A total 812 211 unrelated volunteer donors from China Marrow Donor Program (CMDP) were analyzed. Six hundred seventy-six alleles at HLA-A, -B, -C, -DRB1, -DQB1 loci defined as population, including 159 517 alleles....
RV6Sn6 (R = Sc, Y, or rare earth) is a new family of kagome metals that have similar vanadium structural motif as AV3Sb5 (A K, Rb, Cs) compounds. Unlike AV3Sb5, ScV6Sn6 the only compound among series displays charge density wave (CDW) order at ambient pressure, yet it shows no superconductivity (SC) low temperatures. Here, we perform high-pressure transport study on single crystal to track evolutions CDW transition and explore possible SC. In contrast compounds, can be suppressed completely...
Allogeneic hematopoietic stem cell transplantation is a widely used and effective therapy for malignant diseases numerous other disorders. High-resolution human leukocyte antigen (HLA) haplotype frequency distributions not only facilitate individual donor searches but also determine the probability with which particular patient can find HLA-matched donors in registry. The frequencies of HLA-A, -B, -C, -DRB1, -DQB1 alleles haplotypes were estimated among 169,995 Chinese volunteers using...
Abstract Background Tissue regeneration disorder after endometrial injury is an important cause of intrauterine adhesions, amenorrhea, and infertility in women. Both bone marrow mesenchymal stem cell (BMSC) transplantation electroacupuncture (EA) are promising therapeutic applications for injury. This study examined their combined effects on thin endometrium rats the possible mechanisms underlying these effects. Methods A model was established Sprague-Dawley (SD) by perfusing 95% ethanol...
Abstract Background Premature ovarian insufficiency (POI) is a major cause of infertility. In this study, we aimed to investigate the effects combination bone marrow mesenchymal stem cells (BMSCs) and moxibustion (BMSCs-MOX) on POI evaluate underlying mechanisms. Methods A rat model was established by injecting different doses cyclophosphamide (Cy). The modeling treatments were assessed evaluating estrous cycle, serum hormone levels, weight, index, histopathological analysis. BMSCs migration...
Objective The present study was designed to examine the anticancer effect of Traditional Chinese Medicine polyphyllin I (PPI) and evodiamine (EVO) on freshly–removed gastric tumor tissues. Methods Sixty tissues were collected. Their sensitivity PPI, EVO, platinum (Pt), 5-FU, irinotecan (CPT-11) determined by histoculture drug response assay (HDRA). Those samples also formalin-fixed paraffin-embedded, which used mRNA expression levels aprataxin(APTX), excision repair cross-complementing...
Moxibustion, a common therapy in traditional Chinese medicine, has potential benefits for treating decreased ovarian reserve (DOR). The present study investigates the protective effect of moxibustion rat model DOR and explores possible mechanisms.Sixty-four female Sprague-Dawley rats were randomly divided into four groups: control, DOR, (MOX), hormone replacement (HRT). was established by intragastric administration 50 mg/kg Tripterygium glycoside suspension (TGS), once daily 14 days. MOX...
Cytokine-induced memory-like natural killer (CIML NK) cells have been found to possess potent antitumor responses and induce complete remissions in patients with leukemia. However, the poor infiltration of transferred NK is a major obstacle developing adoptive cell immunotherapy for solid tumors. In our study, we explored potential using tumor-penetrating peptide iRGD deliver activated CIML deep into tumor tissues.After being briefly stimulated interleukin-12 (IL-12), IL-15, IL-18, were...
Radiomic models combining intratumoral with peritumoral features are potentially beneficial to enhance the predictive performance. This study aimed identify optimal 18F-FDG PET/CT-derived radiomic for prediction of prognosis in hepatocellular carcinoma (HCC). A total 135 HCC patients from two institutions were retrospectively included. Four regions defined by dilating tumor region thicknesses 2 mm, 4 6 and 8 respectively. Based on segmentation intratumoral, integrated volume interest (VOI),...
Abstract Objectives To assess the safety and efficacy of anlotinib (a multi‐targeted tyrosine kinase inhibitor) combined with toripalimab PD‐1 monoclonal antibody) in treatment unresectable biliary tract cancer (BTC). Methods In this prospective, single‐arm, single‐centre exploratory clinical study, patients locally progressed or metastatic BTC were included. Patients treated (12 mg, PO, QD, for 2 weeks then stopped a week, 21 days cycle) (240 IV, Q3W). The primary endpoint study was...
The frequencies of human leucocyte antigen (HLA)-A, -B and -DRB1 alleles haplotypes were statistically analysed among 3238 donors from Chinese Marrow Donor Program (CMDP) Jiangsu Branch. All typed using polymerase chain reaction-sequence-based typing (PCR-SBT) method or reaction-reverse sequence-specific oligonucleotide probe (PCR-rSSOP) method. As a result, total 46 A, 85 B 51 DRB1 found in population. first three frequent HLA-A, loci respectively A*11:01(16.52%), A*24:02(15.10%)...
Background . In vitro fertilization and embryo transfer (IVF-ET) technology has been widely used in the therapy of refractory infertility. Previous studies showed that acupuncture can effectively increase clinical pregnancy rate IVF-ET. However, molecular mechanism is unknown. Materials Methods this study, we performed whole transcriptome sequencing for endometrial samples from infertile women who underwent moxibustion or not. Differentially expressed noncoding RNAs (ncRNAs) mRNAs were...
HLA‐DRB1*12:108 differs from HLA‐DRB1*12:02:01:01 by one nucleotide in exon 2.
A thin endometrium affects the success of assisted reproduction due to low endometrial receptivity. Acupuncture improves receptivity and promotes formation pinopodes, ultrastructure marker implantation window. However, specific underlying mechanisms remain unclear. In this study, efficacy acupuncture treatment its mechanism were investigated by analyzing pregnancy rate, pinopode formation, related molecular markers in model rats. Absolute ethanol (95%) was injected into uteruses female...
Angelica polysaccharide (APS) is a extracted from sinensis and it one of the main active components sinensis. Many studies have demonstrated that APS can promote activation function variety immune cells recognized as an enhancer, but regulatory effect on myeloid-derived suppressor (MDSC) still unclear. In this study, we investigated effects MDSC proliferation, differentiation through in vivo vitro experiments. , our results showed promoted immunosuppressive STAT1 STAT3 signaling pathways,...
This study aimed to investigate the protective effects of moxibustion on ovarian dysfunction in rats with cyclophosphamide (Cy)-induced premature insufficiency (POI). It also at revealing its potential mechanisms and emphasizing role mitigating mitochondrial NLRP3 inflammatory activation. POI models were established by intraperitoneal administration Cy using female Sprague–Dawley rats. Moxibustion (BL23 or CV4, CV8) was used treat for fifteen days. Vaginal smears, enzyme-linked immunosorbent...
AIMTo assess the efficacy and safety of a new treatment modality, cellular immune therapy based on personalized peptide vaccination (PPV-DC-CTL) combined with radiotherapy, for treating advanced hepatocellular carcinoma (HCC). METHODSA total nine patients HCC were enrolled.Multidisciplinary consultation confirmed that
The present study aimed to determine the profile of differentially expressed circular RNAs (circRNAs) in infertile patients treated with acupuncture and moxibustion verify role altering endometrial receptivity (ER). High‑throughput RNA sequencing bioinformatics analysis samples from six pairs or without were conducted. reliability high‑throughput was validated using reverse transcription‑quantitative PCR. most significant circRNA functions pathways selected by gene ontology (GO) Kyoto...