A5083899273- Bone Tissue Engineering Materials
- Dental materials and restorations
- Electrospun Nanofibers in Biomedical Applications
- Dental Implant Techniques and Outcomes
- Graphene and Nanomaterials Applications
- Advanced Sensor and Energy Harvesting Materials
- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- Endodontics and Root Canal Treatments
- Tissue Engineering and Regenerative Medicine
- biodegradable polymer synthesis and properties
- Nanoplatforms for cancer theranostics
- Dental Radiography and Imaging
- Bone Metabolism and Diseases
- 3D Printing in Biomedical Research
- Biochemical and Molecular Research
- Oral microbiology and periodontitis research
- Planarian Biology and Electrostimulation
- Bone and Dental Protein Studies
- Calcium Carbonate Crystallization and Inhibition
- Dental Erosion and Treatment
- Polymer Surface Interaction Studies
- Nanoparticle-Based Drug Delivery
- Extracellular vesicles in disease
- Dental Research and COVID-19
Peking University
2016-2025
National Clinical Research Center for Digestive Diseases
2023-2025
Guizhou Normal University
2025
King University
2013-2025
National Clinical Research
2024-2025
Yunnan Agricultural University
2024-2025
Anyang Institute of Technology
2025
Henan Polytechnic University
2025
Affiliated Hospital of North Sichuan Medical College
2025
University of South China
2024
Fe3O4 magnetic nanoparticles (MNPs) were synthesized by a co-precipitation method using sodium citrate and oleic acid as modifiers. Phase composition microstructure analysis indicate that the have been successfully grafted onto surface of MNPs. The behaviors reveal modification can decrease saturation magnetization MNPs due to effect. modified sodiumcitrate show excellent dispersion capability, which should be ascribed great reduction high energy dipolar attraction nanoparticles.
Fe$_3$O$_4$ magnetic nanoparticles (MNPs) were synthesized by a co-precipitation method using sodium citrate and oleic acid as modifiers. Phase composition microstructure analysis indicate that the have been successfully grafted onto surface of MNPs. The behaviors reveal modification can decrease saturation magnetization MNPs due to effect. modified sodiumcitrate show excellent dispersion capability, which should be ascribed great reduction high energy dipolar attraction nanoparticles.
In order to provide a more comprehensive understanding of the effects SARS-CoV-2 on oral health and possible saliva transmission, we performed RNA-seq profiles analysis from public databases also questionnaire survey oral-related symptoms COVID-19 patients.To analyse ACE2 expression in salivary glands, bulk four datasets including 31 patients were recruited. Saliva oropharyngeal swabs collected. nucleic acids detected by real-time polymerase chain reaction (RT-PCR). Additionally, various...
Physiological electric potential is well-known for its indispensable role in maintaining bone volume and quality. Although implanted biomaterials simulating structural, morphological, mechanical, chemical properties of natural tissue or organ has been introduced the field regeneration, concept restoring physiological microenvironment remains ignored design. In this work, a flexible nanocomposite membrane mimicking endogenous fabricated to explore defect repair efficiency. BaTiO3...
Tooth enamel, renowned for its high stiffness, hardness, and viscoelasticity, is an ideal model designing biomimetic materials, but accurate replication of complex hierarchical organization high-performance biomaterials in scalable abiological composites challenging. We engineered enamel analog with the essential structure at multiple scales through assembly amorphous intergranular phase (AIP)-coated hydroxyapatite nanowires intertwined polyvinyl alcohol. The nanocomposite simultaneously...
Abstract Nanozymes, as one of the most efficient reactive oxygen species (ROS)‐scavenging biomaterials, are receiving wide attention in promoting diabetic wound healing. Despite recent attempts at improving catalytic efficiency Pt‐based nanozymes (e.g., PtCu, best systems), they still display quite limited ROS scavenging capacity and ROS‐dependent antibacterial effects on bacteria or immunocytes, which leads to uncontrolled poor Hence, a new class multifunctional PtCuTe nanosheets with...
Titanium carbide MXene combines high mechanical and electrical properties low infrared emissivity, making it of interest for flexible electromagnetic interference (EMI) shielding thermal camouflage film materials. Conventional wisdom holds that large is the preferable building block to assemble high-performance films. However, voids in films comprising degrade their properties. Although traditional crosslinking strategies can diminish voids, electron transport between flakes usually...
Abstract Polymer dielectrics with high breakdown strength ( E b ) and efficiency are urgently demanded in advanced electrical electronic systems, yet their energy density U e is limited due to low dielectric constant (ε r loss at elevated temperatures. Conventional inorganic fillers diameters from nano micrometers can only increase ε the cost of compromised poor compatibility polymer matrix. Herein, hydroxyapatite (HAP) sub‐nanowires a diameter ≈0.9 nm incorporated polyetherimide (PEI)...
Abstract For bone defect repair under co-morbidity conditions, the use of biomaterials that can be non-invasively regulated is highly desirable to avoid further complications and promote osteogenesis. However, it remains a formidable challenge in clinical applications achieve efficient osteogenesis with stimuli-responsive materials. Here, we develop polarized CoFe 2 O 4 @BaTiO 3 /poly(vinylidene fluoridetrifluoroethylene) [P(VDF-TrFE)] core-shell particle-incorporated composite membranes...
Abstract Utilization of electro‐responsive biomaterials with antibacterial properties is advantageous for facilitating septic wound healing and tissue regeneration. However, the dose‐response effects electrical stimuli from these materials against bacteria are not rigorously characterized, achieving synergy bactericidal pro‐regenerative remains a major challenge. Here, graded series flexible BaTiO 3 /P(VDF‐TrFE) electroactive nanocomposite membranes (EMs) developed varying surface charge...
Abstract The electrospinning of gelatin aqueous solution was successfully carried out by elevating the spinning temperature. effects temperature and concentration were investigated on morphology nanofibers in current study. To improve stability mechanical properties moist state, nanofibrous membrane chemically crosslinked 1‐ethyl‐3‐dimethyl‐aminopropyl carbodiimide hydrochloride N ‐hydroxyl succinimide. crosslinker optimized measuring swelling degree weight loss. Nanofibrous structure...
Abstract Poly‐ L ‐lactic acid (PLLA)/hydroxyapatite (HA) hybrid membranes were fabricated via electrospinning of the PLLA/HA dispersion for use in bone tissue regeneration. The structural properties and morphologies PLLA membrane investigated by measuring Brunauer‐Emmett‐Teller specific surface area, observations SEM, TEM. integrating HA nanoparticles studied energy X‐ray analysis FTIR. mechanical also measured tensile tests. For exploring biological behaviors membrane, vitro degradation...
Significant effort has been devoted to fabricating various biomaterials satisfy specific clinical requirements. In this study, we developed a new type of guided tissue regeneration (GTR) membrane by electrospinning suspension consisting poly(l-lactic acid), multiwalled carbon nanotubes, and hydroxyapatite (PLLA/MWNTs/HA). MWNTs/HA nanoparticles were uniformly dispersed in the membranes, degradation characteristics far improved. Cytologic research revealed that PLLA/MWNTs/HA enhanced adhesion...
Currently, it is still a tough task for dentists to remineralize dentine in deep caries. The aim of this study was demineralized tooth model caries using nanocomplexes carboxymethyl chitosan/amorphous calcium phosphate (CMC/ACP) based on mimicking the stabilizing effect matrix protein 1 (DMP1) ACP biomineralization dentine. experimental results indicate that CMC can stabilize form CMC/ACP, which able be processed into scaffolds by lyophilization. In single-layer collagen model, nanoparticles...
In recent years, interest in magnetic biomimetic scaffolds for tissue engineering has increased considerably. The aim of this study is to develop biodegradable fibrous materials with potential use bone regeneration. Magnetic Fe3O4/chitosan (CS)/poly vinyl alcohol (PVA) nanofibrous membranes were achieved by electrospinning average fiber diameters ranging from 230 380 nm and porosity 83.9–85.1%. influences polymer concentration, applied voltage Fe3O4 nanoparticles loading on the fabrication...
Macrophage-mediated inflammation compromises bone repair in diabetic patients. Electrical signaling cues are known to regulate macrophage functions. However, the biological effects of electrical microenvironment from charged biomaterials on immune response for regulating osteogenesis under conditions remain be elucidated. Herein endogeneous native tissue was recapitulated by fabricating a ferroelectric BaTiO3/poly (vinylidene fluoridetrifluoroethylene) (BTO/P(VDF-TrFE)) nanocomposite...
Abstract Rapid and effective osseointegration is a great challenge in clinical practice. Endogenous electronegative potentials spontaneously appear on bone defect sites mediate healing. Thus, healing can potentially be stimulated using physiologically relevant electrical signals implants. However, it difficult to directly introduce electric fields tissue. In this study, built‐in are established between electropositive ferroelectric BiFeO 3 (BFO) nanofilms walls trigger implant biological...
Background The interactions between the gut microbiome and obesity have been extensively studied. Although oral cavity is gateway to gut, colonized with microbes, little known about in people obesity. In present study, we investigated salivary obese normal weight healthy participants using metagenomic analysis. subjects were categorized into two groups, weight, based on their BMIs. Methods We characterized of 33 adults 29 controls high-throughput sequencing V3–V4 region 16S rRNA gene...
Abstract In situ regeneration of the enamel‐like structure hydroxyapatite (HAp) crystals under oral conditions is significant for dental caries treatment. However, it still a challenge dentists to duplicate elegant and well‐aligned apatite bonding surface demineralized enamel. A biocompatible amelogenin‐inspired matrix, phase‐transited lysozyme (PTL) film mimicking an N‐terminal amelogenin with central domain (N‐Ame) combined synthetic peptide (C‐AMG) based on functional domains C‐terminal...
Abstract Background Bone marrow-derived mesenchymal stem cell (BMSC) transplantation is considered a promising therapeutic approach for bone defect repair. However, during the procedure, functions and viability of BMSCs may be impaired due to extended durations in vitro culture, aging, disease conditions patients. Inspired by spontaneous intercellular mitochondria transfer that naturally occurs within injured tissues rescue cellular or tissue function, we investigated whether artificial into...