A5100371486- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Liver Disease and Transplantation
- Inflammatory Bowel Disease
- Liver Diseases and Immunity
- interferon and immune responses
- Liver Disease Diagnosis and Treatment
- Vehicle emissions and performance
- Drug-Induced Hepatotoxicity and Protection
- Pediatric Hepatobiliary Diseases and Treatments
- Cytokine Signaling Pathways and Interactions
- Air Quality Monitoring and Forecasting
- Odor and Emission Control Technologies
- Reproductive System and Pregnancy
Wenzhou Medical University
2016-2021
First Affiliated Hospital of Wenzhou Medical University
2016-2021
Northwest A&F University
2021
Ministry of Agriculture and Rural Affairs
2021
Shenzhen University
2017
Zhejiang University of Technology
2012
Primary biliary cholangitis (PBC) is a classical autoimmune disease, which highly influenced by genetic determinants. Many genome-wide association studies (GWAS) have reported that numerous loci were significantly associated with PBC susceptibility. However, the effects of determinants on liver cells and its immune microenvironment for remain unclear.We constructed powerful computational framework to integrate GWAS summary statistics scRNA-seq data uncover genetics-modulated cell...
Aims . Acute-on-chronic liver failure (ACLF) and acute (ALF) are similar in many respects during their exacerbation; however, ACLF generally has a poorer prognosis. We aimed to investigate the role dynamic changes of regulatory T cell (Treg) helper 17 (Th17) proportions progress. Methods All rats were classified into two groups randomly: group ALF (control group). The rat model was preestablished by intraperitoneal injection carbon tetrachloride for 2 months. Then injury induced combined...
The pathogenesis of the immune regulation dysfunction is unclear. Bcl2-like protein 12 (Bcl2L12) has suppression function. This study tests a hypothesis that tumor necrosis factor (TNF) increases Bcl2L12 to suppress expression interleukin (IL) 10 in peripheral B cells patients with inflammatory bowel disease (IBD). In this study, blood samples were collected from IBD and healthy controls. isolated samples. IL-10 was analyzed by quantitative reverse transcription polymerase chain reaction...
Endometritis is a common and important reproductive disease of domestic animals. The principal factors responsible for the are infection with Gram-negative bacteria, release Lipopolysaccharides (LPS) activation TLR4/NF-κB signaling pathway. However, we do not fully understand interaction between endometrial immunity bacterial in etiology. ubiquitin-like protein ISG15 can regulate pathway via ISGylation modification system, modulating inflammatory response. In present study, found that was...
Acute liver failure (ALF) is a potentially fatal clinical syndrome with no effective treatment. This study aimed to explore the role of Janus kinase 2/signal transducer and activator transcription 3 (JAK2/STAT3) pathway in modulating phenotype immune function endotoxin-tolerant dendritic cells (ETDCs). In addition, we explored use EDTCs an experimental model ALF investigated associated mechanisms.In vitro experiment, ETDCs were transfected adenovirus induce SOCS1+/+ETDCs SOCS1-/-ETDCs....
Abstract Endotoxin tolerance (ET) is suggested to attenuate the severity of acute liver failure (ALF) in mice, possibly through both innate and adaptive immunity. However, involvement regulatory dendritic cells (DCregs) ET has not been fully elucidated. In this study, their effect on ALF mice was investigated. Splenic DCregs from ET-exposed (ET-DCregs) showed lower expression levels CD40, CD80, MHC-II markers stronger inhibition allogenic T regulation IL-10 IL-12 secretion than splenic...
Objective To study the changes of immune function endotoxin tolerant dendritic cell (ETDC) and to observe its effect on sepsis in mouse model. Methods ETDC were prepared by pretreated bone marrow cells derived from BALB/c mice with lipopolysaccharide stimulation. The collected expressions surface markers including major histocompatibility complex (MHC)Ⅱ, CD86 CD11c detected flow cytometry. proliferation rate T lymphocytes was evaluated counting kit-8 concentrations cytokines...
Abstract Sepsis refers to the body's dysfunctional response infection and leads life-threatening organ dysfunction. Dentritic cells (DCs), a kind of powerful functional antigen-presenting cell, plays critical role in immune has been used field immunotherapy for multiple diseases. Endotoxin tolerance is phenomenon that believed prevent organism from producing persistent excessive inflammatory reaction numerous studies indicated endotoxin tolerant dendritic (ETDCs) have therapeutic effects on...