A5013046978- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Immune cells in cancer
- Immune Cell Function and Interaction
- Genetics, Bioinformatics, and Biomedical Research
- Aluminum Alloy Microstructure Properties
- Single-cell and spatial transcriptomics
- Cancer Immunotherapy and Biomarkers
- Land Use and Ecosystem Services
- Microstructure and mechanical properties
- Genetic factors in colorectal cancer
- CAR-T cell therapy research
- CRISPR and Genetic Engineering
- Glioma Diagnosis and Treatment
- Viral Infectious Diseases and Gene Expression in Insects
- Brain Metastases and Treatment
- Aluminum Alloys Composites Properties
- COVID-19 Clinical Research Studies
- Gastric Cancer Management and Outcomes
- Advancements in Semiconductor Devices and Circuit Design
- Genomics and Rare Diseases
- Liver Diseases and Immunity
- Pediatric Hepatobiliary Diseases and Treatments
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
Peter MacCallum Cancer Centre
2019-2024
The University of Melbourne
2019-2024
Zhejiang University
2022-2023
National Cheng Kung University
2023
Central South University
2023
Wenzhou Medical University
2020-2022
Affiliated Eye Hospital of Wenzhou Medical College
2020-2022
The Royal Melbourne Hospital
2019-2021
Kunming University of Science and Technology
2019
Kunming University
2019
Abstract Tumor-associated macrophages (TAMs), one of the most abundant immune components in gastric cancer (GC), are difficult to characterize due their heterogeneity. Multiple approaches have been used elucidate issue, however, tissue-destructive nature these methods, spatial distribution TAMs situ remains unclear. Here we probe relationship between tumor context and TAM heterogeneity by multiplex immunohistochemistry 56 human GC cases. Using distinct expression marker profiles on TAMs,...
Previously, a large volume of papers reports that gold nanorods (Au NRs) are able to effectively kill cancer cells upon high laser doses (usually 808 nm, 1-48 W/cm²) irradiation, leading hyperthermia-induced destruction cells, i.e, photothermal therapy (PTT) effects. Combination Au NRs-mediated PTT and organic photosensitizers-mediated photodynamic (PDT) were also reported achieve synergistic PDT effects on killing cells. Herein, we demonstrate for the first time NRs alone can sensitize...
Abstract Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of haematological malignancies such as acute lymphoblastic leukaemia, B lymphoma and multiple myeloma 1–4 , but efficacy CAR in solid tumours been limited 5 . This is owing to a number factors, including immunosuppressive tumour microenvironment that gives rise poorly persisting metabolically dysfunctional cells. Analysis anti-CD19 cells used clinically shown positive outcomes are associated with more...
Abstract Spatial proteomics technologies have revealed an underappreciated link between the location of cells in tissue microenvironments and underlying biology clinical features, but there is significant lag development downstream analysis methods benchmarking tools. Here we present SPIAT (spatial image tissues), a spatial-platform agnostic toolkit with suite spatial algorithms, spaSim simulator), simulator data. includes multiple colocalization, neighborhood heterogeneity metrics to...
Understanding the host genetic architecture and viral immunity contributes to development of effective vaccines therapeutics for controlling COVID-19 pandemic. Alterations immune responses in peripheral blood mononuclear cells play a crucial role detrimental progression COVID-19. However, effects factors on severe remain largely unknown.We constructed computational framework characterize genetics that influence cell subpopulations by integrating GWAS summary statistics (N = 969,689 samples)...
Carbon emissions are closely related to global warming. More than 70% of carbon have been generated in cities. Many studies analyzed the effects cities on emissions, from perspective urbanization, economics, and land use, yet a detailed understanding relationship between urban form is lacking due absence reasonable set metrics. The aim this research explore through empirical research. By eliminating collinearity, we established landscape metrics comprising Class Area (CA), Mean...
Purpose The presence of tumor-infiltrating lymphocytes (TILs) in tumors is superior to conventional pathologic staging predicting patient outcome. However, their does not define TIL functionality. Here we developed an assay that tests cytotoxicity patients with locally advanced rectal cancer before definitive treatment, identifying those who will obtain a complete response (pCR). We also used the demonstrate rescue function after checkpoint inhibition blockade (CIB). Patients and Methods...
Biological pathway analysis provides new insights for cell clustering and functional annotation from single-cell RNA sequencing (scRNA-seq) data. Many algorithms have been developed to transform gene-level scRNA-seq data into gene sets representing pathways or biological processes. Here, we collected seven widely-used activity transformation 32 available datasets based on 16 techniques. We proposed a comprehensive framework evaluate their accuracy, stability scalability. The assessment of...
The systematic identification of host genetic risk factors is essential for the understanding and treatment coronavirus disease 2019 (COVID-19). By performing a meta-analysis two independent genome-wide association summary datasets (N = 680 128), novel locus at 21q22.11 was identified to be associated with COVID-19 infection (rs9976829 in IFNAR2-IL10RB, odds ratio 1.16, 95% confidence interval 1.09-1.23, P 2.57 × 10-6). rs9976829 represents strong splicing quantitative trait both IFNAR2...
Abstract Objectives To facilitate disease prognosis and improve precise immunotherapy of gastric cancer (GC) patients, a comprehensive study integrating immune cellular molecular analyses on tumor tissues peripheral blood was performed. Methods The association GC patients’ outcomes the context their tumors explored using multiplex immunohistochemistry (mIHC) transcriptome profiling. Potential dysfunction mechanism/s in systemic level further examined mass cytometry (CyTOF) complementary from...
Primary biliary cholangitis (PBC) is a classical autoimmune disease, which highly influenced by genetic determinants. Many genome-wide association studies (GWAS) have reported that numerous loci were significantly associated with PBC susceptibility. However, the effects of determinants on liver cells and its immune microenvironment for remain unclear.We constructed powerful computational framework to integrate GWAS summary statistics scRNA-seq data uncover genetics-modulated cell...
Abstract Objective Gastric cancer patients generally have a poor outcome, particularly those with advanced-stage disease which is defined by the increased invasion of locally and associated higher metastatic potential. This study aimed to identify genes that were functional in most fundamental hallmark cancer, namely invasion. We then wanted assess their value as biomarkers gastric progression recurrence. Design Data from cohort profiled on cDNA expression arrays was interrogated using...
Heat dissipation is a critical issue in high-performance electronics, which needs to be solved, and an electronic paste good choice solve this issue. In paper, silver nanoparticles/multi-walled carbon nanotube (Ag-NPs/MWCNT) composites were prepared by the chemical process for modification of pastes. The micromorphology spectral analysis as-prepared Ag-NPs/MWCNT indicated that Ag-NPs uniformly distributed on MWCNT surfaces with high distribution densities; average size was estimated 8.29 nm....
CXCL9 expression is a strong predictor of response to immune checkpoint blockade therapy. Accordingly, we sought develop therapeutic strategies enhance the and augment antitumor immunity. To perform whole-genome CRISPR-Cas9 screening for regulators expression, CXCL9-GFP reporter line generated using CRISPR knockin strategy. This approach finds that IRF1 limits in both tumor cells primary myeloid through induction SOCS1, which subsequently STAT1 signaling. Thus, identify subset...
Abstract Background Identifying breast cancer patients with DNA repair pathway-related germline pathogenic variants (GPVs) is important for effectively employing systemic treatment strategies and risk-reducing interventions. However, current criteria risk prediction models prioritizing genetic testing among do not meet the demands of clinical practice due to insufficient accuracy. Methods The study population comprised 3041 enrolled from seven hospitals between October 2017 11 August 2019,...